ATE556708T1 - Corrole für neuroprotektion und neuro-rescue - Google Patents
Corrole für neuroprotektion und neuro-rescueInfo
- Publication number
- ATE556708T1 ATE556708T1 AT09705986T AT09705986T ATE556708T1 AT E556708 T1 ATE556708 T1 AT E556708T1 AT 09705986 T AT09705986 T AT 09705986T AT 09705986 T AT09705986 T AT 09705986T AT E556708 T1 ATE556708 T1 AT E556708T1
- Authority
- AT
- Austria
- Prior art keywords
- corrole
- neuroprotection
- propargyl
- tris
- corroles
- Prior art date
Links
- LYNARWYQOUZXDY-UHFFFAOYSA-N corrole Chemical compound N1C(C=C2NC(=CC=3NC4=CC=3)C=C2)=CC=C1C=C1C=CC4=N1 LYNARWYQOUZXDY-UHFFFAOYSA-N 0.000 title abstract 2
- 230000004112 neuroprotection Effects 0.000 title abstract 2
- 230000001918 neurorescue Effects 0.000 title abstract 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 2
- 229910052723 transition metal Inorganic materials 0.000 abstract 2
- 150000003624 transition metals Chemical class 0.000 abstract 2
- 125000006321 2-propynyl amino group Chemical group [H]C#CC([H])([H])N([H])* 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2504308P | 2008-01-31 | 2008-01-31 | |
| PCT/IL2009/000121 WO2009095923A2 (en) | 2008-01-31 | 2009-02-01 | Corroles for neuroprotection and neurorescue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556708T1 true ATE556708T1 (de) | 2012-05-15 |
Family
ID=40673542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09705986T ATE556708T1 (de) | 2008-01-31 | 2009-02-01 | Corrole für neuroprotektion und neuro-rescue |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110098262A1 (de) |
| EP (1) | EP2244701B1 (de) |
| AT (1) | ATE556708T1 (de) |
| CA (1) | CA2751058A1 (de) |
| ES (1) | ES2387535T3 (de) |
| WO (1) | WO2009095923A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011075122A (ja) * | 2009-09-29 | 2011-04-14 | Sumitomo Light Metal Ind Ltd | アルミニウム製内面溝付伝熱管 |
| US9642860B2 (en) | 2011-08-15 | 2017-05-09 | Technion Research & Development Foundation Limited | Combinations of corroles and statins |
| US9572816B2 (en) | 2012-10-25 | 2017-02-21 | Technion Research And Development Foundation Ltd. | Method of treatment of disease |
| JP2016509016A (ja) | 2013-02-13 | 2016-03-24 | カリフォルニア インスティチュート オブ テクノロジー | 金属酸化物のスルホン酸エステル及びその使用の方法 |
| CN108451930A (zh) * | 2013-05-08 | 2018-08-28 | 西塞医疗中心 | 用于肿瘤毒性和mri的靶向可咯 |
| WO2015108567A1 (en) * | 2014-01-17 | 2015-07-23 | California Institute Of Technology | Sulfonic esters of metal oxides and methods of their use |
| EP3687998A4 (de) * | 2017-08-31 | 2021-05-19 | Technion Research & Development Foundation Limited | Corrolzusammensetzungen |
| EP3492079A1 (de) * | 2017-11-29 | 2019-06-05 | Université de Bourgogne | Corrole zur behandlung einer pockenvirusinfektion |
| EP3492078A1 (de) * | 2017-11-29 | 2019-06-05 | Université de Bourgogne | Korrolen zur behandlung von humanen cytomegalovirus-infektionen |
| WO2022153294A1 (en) | 2021-01-14 | 2022-07-21 | Technion Research & Development Foundation Ltd | Low molecular weight corrole compositions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2257858T3 (es) * | 1998-04-24 | 2006-08-01 | Duke University | Porfirinas sustituidas. |
| IL126426A0 (en) * | 1998-09-29 | 1999-05-09 | Technion Res & Dev Foundation | Process for the preparation of corroles several such new compounds including chiral derivatives and the use thereof |
| IL126953A0 (en) * | 1998-11-08 | 1999-09-22 | Yeda Res & Dev | Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives |
| US6939963B2 (en) * | 2001-07-02 | 2005-09-06 | Technion Research And Development Foundation Ltd. | Method for the preparation of selectively-substituted corroles and new substituted corroles |
-
2009
- 2009-02-01 WO PCT/IL2009/000121 patent/WO2009095923A2/en not_active Ceased
- 2009-02-01 CA CA2751058A patent/CA2751058A1/en not_active Abandoned
- 2009-02-01 US US12/865,793 patent/US20110098262A1/en not_active Abandoned
- 2009-02-01 EP EP09705986A patent/EP2244701B1/de not_active Not-in-force
- 2009-02-01 ES ES09705986T patent/ES2387535T3/es active Active
- 2009-02-01 AT AT09705986T patent/ATE556708T1/de active
-
2013
- 2013-09-03 US US14/016,262 patent/US20140045809A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2244701A2 (de) | 2010-11-03 |
| CA2751058A1 (en) | 2009-08-06 |
| US20110098262A1 (en) | 2011-04-28 |
| ES2387535T3 (es) | 2012-09-25 |
| US20140045809A1 (en) | 2014-02-13 |
| EP2244701B1 (de) | 2012-05-09 |
| WO2009095923A2 (en) | 2009-08-06 |
| WO2009095923A3 (en) | 2010-03-18 |
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