ATE556773T1 - Mikrofluidische geräte und systeme mit deckschichten - Google Patents

Mikrofluidische geräte und systeme mit deckschichten

Info

Publication number
ATE556773T1
ATE556773T1 AT99936040T AT99936040T ATE556773T1 AT E556773 T1 ATE556773 T1 AT E556773T1 AT 99936040 T AT99936040 T AT 99936040T AT 99936040 T AT99936040 T AT 99936040T AT E556773 T1 ATE556773 T1 AT E556773T1
Authority
AT
Austria
Prior art keywords
microfluidic devices
systems
body structure
cover layers
disposed
Prior art date
Application number
AT99936040T
Other languages
English (en)
Inventor
Robert Dubrow
Colin Kennedy
Robert Nagle
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21846482&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE556773(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE556773T1 publication Critical patent/ATE556773T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Laminated Bodies (AREA)
AT99936040T 1998-02-24 1999-02-23 Mikrofluidische geräte und systeme mit deckschichten ATE556773T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/028,965 US6251343B1 (en) 1998-02-24 1998-02-24 Microfluidic devices and systems incorporating cover layers
PCT/US1999/003902 WO1999043432A1 (en) 1998-02-24 1999-02-23 Microfluidic devices and systems incorporating cover layers

Publications (1)

Publication Number Publication Date
ATE556773T1 true ATE556773T1 (de) 2012-05-15

Family

ID=21846482

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99936040T ATE556773T1 (de) 1998-02-24 1999-02-23 Mikrofluidische geräte und systeme mit deckschichten

Country Status (5)

Country Link
US (2) US6251343B1 (de)
EP (2) EP2266695A3 (de)
AT (1) ATE556773T1 (de)
AU (1) AU3308199A (de)
WO (1) WO1999043432A1 (de)

Families Citing this family (322)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6100541A (en) * 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7497994B2 (en) * 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6896849B2 (en) * 1998-10-29 2005-05-24 Applera Corporation Manually-operable multi-well microfiltration apparatus and method
US6906292B2 (en) * 1998-10-29 2005-06-14 Applera Corporation Sample tray heater module
US6159368A (en) * 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
US6689323B2 (en) 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
ATE508200T1 (de) 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US7001774B1 (en) * 1999-03-05 2006-02-21 Microliter Analytical Supplies, Inc. Sample collection and processing device
US6306578B1 (en) * 1999-03-19 2001-10-23 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
AU5291600A (en) 1999-06-01 2000-12-18 Caliper Technologies Corporation Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
DE19928412C2 (de) * 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US6858185B1 (en) * 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
GB9922971D0 (en) * 1999-09-29 1999-12-01 Secr Defence Reaction system
US6908594B1 (en) * 1999-10-22 2005-06-21 Aclara Biosciences, Inc. Efficient microfluidic sealing
EP1716925B1 (de) * 1999-10-22 2008-12-24 Ngk Insulators, Ltd. Flüssigkeitsspender und Verfahren zur Herstellung von DNA chip
CA2387064A1 (en) 1999-10-22 2001-05-03 Torlief Ove Bjornson Sealing for microfluidic devices
US6878255B1 (en) * 1999-11-05 2005-04-12 Arrowhead Center, Inc. Microfluidic devices with thick-film electrochemical detection
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US6413395B1 (en) 1999-12-16 2002-07-02 Roche Diagnostics Corporation Biosensor apparatus
US6451264B1 (en) * 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels
US6399396B1 (en) * 2000-01-28 2002-06-04 Agilent Technologies, Inc. Compressed loading apparatus and method for liquid transfer
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US6706538B1 (en) 2000-02-29 2004-03-16 Boston Innovation Inc. Microvolume liquid dispensing array
US6620383B1 (en) 2000-02-29 2003-09-16 Boston Innovation Inc. Microvolume liquid dispensing device
DE10013240A1 (de) * 2000-03-09 2001-10-11 Brand Gmbh & Co Kg Anordnung zu kontaminationsfreier Bearbeitung von insbesondere molekularbiologischen Reaktionsabläufen, Verschlußträger und Einzelverschluß für eine solche Anordnung sowie Vorrats-und Abgabeanordnung für Einzelverschlüsse
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US20040132174A1 (en) * 2000-03-28 2004-07-08 Smith Allan Joseph Hilling Perfusion incubator
US7867763B2 (en) * 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
CA2406707A1 (en) * 2000-04-06 2001-10-18 Robert Nagle Microfluidic devices and systems incorporating cover layers
US6698798B2 (en) 2000-04-13 2004-03-02 California Institute Of Technology Micromachined rubber O-ring microfluidic couplers
EP1284816B1 (de) * 2000-05-18 2009-08-05 Millipore Corporation Mehrfachlochplatte mit durch klebe verbundenem filter
WO2001097974A1 (en) * 2000-06-19 2001-12-27 Caliper Technologies Corp. Methods and devices for enhancing bonded substrate yields and regulating temperature
AU2001284700B2 (en) * 2000-08-03 2005-12-08 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
JP3993372B2 (ja) * 2000-09-13 2007-10-17 独立行政法人理化学研究所 リアクタの製造方法
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US7326563B2 (en) * 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US7374906B2 (en) * 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
GB2369086B (en) 2000-11-20 2005-06-08 Herfurth Laser Technology Ltd Reaction plate
SE0004352D0 (sv) * 2000-11-27 2000-11-27 Helen Andersson System och metod för anslutning av vätskor i ett mikrofluidiskt flödescellsystem
DE10060433B4 (de) * 2000-12-05 2006-05-11 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zur Herstellung eines Fluidbauelements, Fluidbauelement und Analysevorrichtung
DE20021326U1 (de) * 2000-12-16 2001-05-31 QIAGEN GmbH, 40724 Hilden Vorrichtung zur Aufnahme von Proben
EP1217375A1 (de) * 2000-12-20 2002-06-26 Direvo Biotech AG Festphasensubstrate für strukturierte Reaktionssubstrate
US6887429B1 (en) * 2001-01-26 2005-05-03 Global Fia Apparatus and method for automated medical diagnostic tests
US6669911B1 (en) * 2001-01-31 2003-12-30 David W. Swanson Frame for multiwell tray
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6742544B2 (en) * 2001-03-07 2004-06-01 Symyx Technologies, Inc. Injection valve array
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
WO2002078229A1 (en) * 2001-03-21 2002-10-03 Stine John A An access and routing protocol for ad hoc networks using synchronous collision resolution and node state dissemination
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
WO2002083852A2 (en) * 2001-04-10 2002-10-24 Bioprocessors Corporation Microfermentor device and cell based screening method
GB0110476D0 (en) 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
US7641780B2 (en) * 2001-05-01 2010-01-05 Calibrant Biosystems, Inc. Two-dimensional microfluidics for protein separations and gene analysis
US6974526B2 (en) * 2001-05-01 2005-12-13 Calibrant Biosystems, Inc. Plastic microfluidics enabling two-dimensional protein separations in proteome analysis
DE10122457A1 (de) * 2001-05-09 2002-11-21 Bosch Gmbh Robert Behälter für einen Analyse-Chip
DE10122659A1 (de) * 2001-05-10 2002-12-05 Infineon Technologies Ag Biochip-Anordnung
US20020187072A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Multi-layer microfluidic splitter
US7179423B2 (en) 2001-06-20 2007-02-20 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US20030015425A1 (en) * 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7211442B2 (en) * 2001-06-20 2007-05-01 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
EP2390721B1 (de) 2001-08-01 2016-03-23 THE STATE OF OREGON, acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of PORTLAND STATE UNIVERSITY Herstellungsverfahren von strukturierten polymerstrukturen, insbesondere mikrostrukturen
US6626051B2 (en) * 2001-08-14 2003-09-30 Investigen Biotechnologies, Inc. Lid for sample holder
WO2003015890A1 (en) * 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
US6969489B2 (en) * 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
US20030044320A1 (en) * 2001-08-31 2003-03-06 Shun Luo High throughput screening micro array platform
US6821898B2 (en) * 2001-09-14 2004-11-23 Wisconsin Alumni Research Foundation Method of forming a multi-layer microfluidic device
US6755949B1 (en) 2001-10-09 2004-06-29 Roche Diagnostics Corporation Biosensor
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
US7767437B2 (en) * 2001-11-02 2010-08-03 Genefluidics, Inc. System for detection of a component in a liquid
US20040054286A1 (en) * 2001-11-05 2004-03-18 Audain Vaughn A Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
US20030087425A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
GB0128350D0 (en) 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
US20030104512A1 (en) * 2001-11-30 2003-06-05 Freeman Alex R. Biosensors for single cell and multi cell analysis
US20050092685A1 (en) * 2002-01-17 2005-05-05 Spark Holland B.V. Set comprising a pipette and a cartridge, as well as a method for applying a sample to the cartridge and an analytical method
US6783737B2 (en) * 2002-01-25 2004-08-31 Bristol-Myers Squibb Company High pressure chemistry reactor
JP3818926B2 (ja) * 2002-02-04 2006-09-06 富士写真フイルム株式会社 リセプター・リガンド会合反応方法
DE10238266A1 (de) * 2002-02-28 2003-11-06 Ibidi Gmbh Mikrofluidsystem
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
AU2003265228A1 (en) * 2002-03-12 2003-12-22 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
WO2003090605A2 (en) * 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20030215369A1 (en) * 2002-05-17 2003-11-20 Eggers Mitchell D. Sample carrier receiver
GB0216077D0 (en) * 2002-07-11 2002-08-21 Univ Cranfield Reconfigurable microfluidic device
US7041258B2 (en) * 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7452509B2 (en) * 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US7459128B2 (en) 2002-08-13 2008-12-02 Molecular Bioproducts, Inc. Microfluidic mixing and dispensing
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
JP3725109B2 (ja) * 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 マイクロ流体デバイス
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
EP1569510B1 (de) 2002-09-27 2011-11-02 The General Hospital Corporation Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
AU2003284055A1 (en) * 2002-10-09 2004-05-04 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
WO2004046689A2 (en) * 2002-11-15 2004-06-03 The Regents Of The University Of California System and method for multiplexed biomolecular analysis
US7344678B2 (en) * 2002-11-15 2008-03-18 The Regents Of The University Of California Composite sensor membrane
EP1565737A4 (de) * 2002-11-20 2007-02-14 Univ Virginia Abtrennung von spermazellen von sonstigen biologischen substanzen unter verwendung von mikrogefertigten geräten, und damit verwandte verfahren
US7718442B2 (en) * 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
AU2003293399A1 (en) * 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
TWI245739B (en) * 2002-12-05 2005-12-21 Ibm Method and device for flowing a liquid on a surface
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
AU2003297214A1 (en) * 2002-12-16 2004-07-22 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
US7087444B2 (en) * 2002-12-16 2006-08-08 Palo Alto Research Center Incorporated Method for integration of microelectronic components with microfluidic devices
EP1608952B1 (de) 2002-12-20 2016-08-10 Life Technologies Corporation Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen
JP2006512092A (ja) * 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
DE10307227A1 (de) * 2003-02-14 2004-08-26 Cytocentrics Ccs Gmbh Verfahren und Vorrichtung zum Kontaktieren einer Mikrofluidstruktur
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7713485B2 (en) * 2003-03-19 2010-05-11 Industrial Technology Research Institute Microfluidics switch with moving planes
JP3892407B2 (ja) * 2003-03-25 2007-03-14 富士通株式会社 撮影装置
US20100075858A1 (en) * 2003-04-29 2010-03-25 Genvault Corporation Biological bar code
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
US20040248306A1 (en) * 2003-06-09 2004-12-09 Hernandez Juan J. Microfluidic water analytical device
EP1654066B1 (de) 2003-07-31 2014-11-12 Handylab, Inc. Verarbeitung von teilchenhaltigen proben
US20050037508A1 (en) * 2003-08-12 2005-02-17 Juan Hernandez Microfluidic titration apparatus
US20050280811A1 (en) * 2003-09-19 2005-12-22 Donald Sandell Grooved high density plate
US20050069462A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfluidics Packaging
US20050069949A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfabricated Fluidic Structures
US20050277125A1 (en) * 2003-10-27 2005-12-15 Massachusetts Institute Of Technology High-density reaction chambers and methods of use
US7396512B2 (en) 2003-11-04 2008-07-08 Drummond Scientific Company Automatic precision non-contact open-loop fluid dispensing
US7476360B2 (en) 2003-12-09 2009-01-13 Genefluidics, Inc. Cartridge for use with electrochemical sensor
CA2549190A1 (en) 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
EP1703968A1 (de) * 2003-12-16 2006-09-27 Unilever Plc Mikrofluidische vorrichtung
KR100572207B1 (ko) * 2003-12-18 2006-04-19 주식회사 디지탈바이오테크놀러지 플라스틱 마이크로 칩의 접합 방법
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
CA2554240A1 (en) * 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
US7569127B1 (en) 2004-02-06 2009-08-04 University Of Central Florida Research Foundation, Inc. Interconnecting microfluidic package and fabrication method
US7666285B1 (en) * 2004-02-06 2010-02-23 University Of Central Florida Research Foundation, Inc. Portable water quality monitoring system
US7439069B2 (en) 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7422905B2 (en) 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8058056B2 (en) * 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
WO2005089945A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
US7399637B2 (en) 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (de) 2004-05-03 2016-12-07 Handylab, Inc. Mikrofluidische Vorrichtung zur Verarbeitung polynukleotidhaltiger Proben
WO2005110601A1 (en) * 2004-05-07 2005-11-24 Optiscan Biomedical Corporation Sample element with separator
WO2005111580A1 (en) * 2004-05-07 2005-11-24 Optiscan Biomedical Corporation Sample element with fringing-reduction capabilities
US20050255448A1 (en) * 2004-05-13 2005-11-17 Arun Majumdar System for amplifying optical detection of cantilever deflection
JP3952036B2 (ja) * 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
CA2567537A1 (en) * 2004-05-21 2005-12-01 Caliper Life Sciences, Inc. Automated system for handling microfluidic devices
EP2168975A3 (de) * 2004-05-24 2012-01-11 Genvault Corporation Methode zur stabilen Lagerung von Biomolekülen in wiedergewinnbarer Form
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
JP2008504845A (ja) * 2004-06-07 2008-02-21 バイオプロセッサーズ コーポレイション リアクター環境条件の制御
EP1609850A1 (de) * 2004-06-24 2005-12-28 Biovir v/Jacob Mollenbach Kulturschale zur Züchtung von biologischen Zellen
KR20070046875A (ko) * 2004-07-29 2007-05-03 쿄세라 코포레이션 마이크로화학 칩
US20060030790A1 (en) * 2004-08-06 2006-02-09 Braig James R Sample element with barrier material and vacuum
WO2006032044A2 (en) 2004-09-15 2006-03-23 Microchip Biotechnologies, Inc. Microfluidic devices
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20060134387A1 (en) * 2004-12-20 2006-06-22 William Gottermeier Multilayer article formed by adhesive ablation
JP2006187685A (ja) * 2004-12-28 2006-07-20 Fuji Xerox Co Ltd 微小構造体、マイクロリアクタ、熱交換器、および微小構造体の製造方法
JP2006187684A (ja) * 2004-12-28 2006-07-20 Fuji Xerox Co Ltd マイクロ流体素子
KR100792296B1 (ko) 2005-01-17 2008-01-07 삼성전자주식회사 펠티에 소자를 이용한 바이오결합 검출장치 및 그 방법
CA2594483C (en) * 2005-01-28 2014-08-26 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070014695A1 (en) * 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
EP1910824A4 (de) 2005-05-31 2012-11-21 Labnow Inc Verfahren und zusammensetzungen in zusammenhang mit der erstellung und verwendung eines weissen blutbildes
EP3029135B1 (de) 2005-07-07 2021-03-17 The Regents of the University of California Vorrichtung für zellkultur-array
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9354156B2 (en) * 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070048189A1 (en) * 2005-08-26 2007-03-01 Applera Corporation Fluid processing device, system, kit, and method
US7798021B2 (en) * 2006-01-12 2010-09-21 Gamble Kimberly R Method and apparatus for sample processing and injection
JP5063616B2 (ja) * 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8293524B2 (en) * 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
EP1872855A1 (de) * 2006-06-27 2008-01-02 F.Hoffmann-La Roche Ag Platte zum Äquilibrieren einer Flüssigkeit
JP4292279B2 (ja) * 2006-07-18 2009-07-08 ファルマ・アクセス株式会社 結晶作製器具
US8656949B2 (en) * 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
HU227018B1 (en) * 2006-10-26 2010-04-28 77 Elektronika Mueszeripari Kf Container to examine urine
US20100061892A1 (en) * 2006-11-03 2010-03-11 The Governors Of The University Of Alberta Microfluidic device having an array of spots
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US20080156080A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
US20080160629A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for off-line multidimensional concentration and separation of biomolecules
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
KR101462131B1 (ko) * 2007-03-21 2014-11-17 소시에떼 비아이씨 유체 다기관 및 그 방법
US20080233011A1 (en) * 2007-03-23 2008-09-25 3M Innovative Properties Company Microfluidic devices
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
CN103495439B (zh) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US20080277356A1 (en) * 2007-05-07 2008-11-13 Caliper Life Sciences, Inc. Microfluidic Device with a Filter
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
CN104307581B (zh) * 2007-08-09 2017-04-12 诺思可有限公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
WO2009021233A2 (en) 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
US8029743B2 (en) * 2007-09-19 2011-10-04 General Electric Company Microfluidic device with vertical injection aperture
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US8120777B2 (en) 2007-12-10 2012-02-21 Molecular Sensing, Inc. Temperature-stable interferometer
US7740747B2 (en) * 2007-12-28 2010-06-22 General Electric Company Injection method for microfluidic chips
US20090166202A1 (en) * 2007-12-28 2009-07-02 General Electric Company Injection method for microfluidic chips
US20090166201A1 (en) * 2007-12-28 2009-07-02 General Electric Company Injection method for microfluidic chips
EP2245453B1 (de) 2008-01-03 2016-10-05 EMD Millipore Corporation Mikrofluidisches zellkulturmatrixsystem für automatisierte tests sowie bedienungsverfahren dafür
EP2234916A4 (de) 2008-01-22 2016-08-10 Integenx Inc Universelles probenpräparationssystem und seine verwendung in einem integrierten analysesystem
EP2285491A1 (de) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Strömungsregelung in mikrofluidiksystemen
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
KR101606603B1 (ko) * 2008-07-25 2016-03-25 플루이다임 코포레이션 집적형 유체 칩의 제조를 위한 방법 및 시스템
JP2012501681A (ja) 2008-09-12 2012-01-26 ジェンボールト コーポレイション 生体分子の貯蔵および安定化のためのマトリックスおよび媒体
US7740748B2 (en) * 2008-10-27 2010-06-22 General Electric Company Electrophoresis system and method
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
US7927476B2 (en) * 2008-12-22 2011-04-19 General Electric Company Injection method for microfluidic chips
KR101180277B1 (ko) * 2008-12-23 2012-09-07 한국전자통신연구원 미세 유체 제어 장치 및 그의 조립 방법
KR20110111449A (ko) * 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
ES2812260T3 (es) * 2009-02-02 2021-03-16 Opko Diagnostics Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
JP5881936B2 (ja) * 2009-04-20 2016-03-09 ソニー株式会社 試料溶液導入キット及び試料溶液注入器
US8309036B2 (en) * 2009-05-15 2012-11-13 Gen-Probe Incorporated Method for separating viscous materials suspended from a pipette
US8388908B2 (en) * 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
RU2559541C2 (ru) 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
GB0913228D0 (en) * 2009-07-29 2009-09-02 Iti Scotland Ltd Loading element
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
PL2504105T3 (pl) 2009-11-24 2021-06-28 Opko Diagnostics, Llc Mieszanie i dostarczanie płynów w układach mikroprzepływowych
US8584703B2 (en) * 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
WO2011094572A2 (en) 2010-01-28 2011-08-04 Shuichi Takayama Hanging drop devices, systems and/or methods
US9125305B2 (en) * 2010-03-17 2015-09-01 Delta Design, Inc. Devices with pneumatic, hydraulic and electrical components
US20110240127A1 (en) * 2010-04-02 2011-10-06 Integenx Inc. Fluidic Article Fabricated In One Piece
JP6104793B2 (ja) 2010-04-16 2017-03-29 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ マイクロ流体システム内でのフィードバック制御
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
JP5978287B2 (ja) 2011-03-22 2016-08-24 サイヴェク・インコーポレイテッド マイクロ流体装置並びに製造及び使用の方法
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
WO2013049165A1 (en) * 2011-09-30 2013-04-04 National Health Research Institutes Microfluidic hanging drop chip
DK2761305T3 (da) 2011-09-30 2017-11-20 Becton Dickinson Co Forenet reagensstrimmel
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
SG11201402558QA (en) 2011-12-03 2014-06-27 Emd Millipore Corp Micro-incubation systems for microfluidic cell culture and methods
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
JP6308954B2 (ja) 2012-03-05 2018-04-11 オサケユキテュア・アークティック・パートナーズ・アクチボラゲットＯｙ Ａｒｃｔｉｃ Ｐａｒｔｎｅｒｓ Ａｂ 前立腺癌のリスク及び前立腺容積を予測する方法及び装置
EP2822688B1 (de) 2012-03-08 2019-09-25 Cyvek, Inc. Anordnungen mikrofluidischer assays und verfahren zur herstellung
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
US20150137015A1 (en) * 2012-07-12 2015-05-21 Agency For Science, Technology And Research Connector for microfluidic device, a method for injecting fluid into microfluidic device using the connector and a method of providing and operating a valve
EP3425401B1 (de) 2012-10-08 2023-09-27 BL Technologies, Inc. Vorgespannte testsubstrate zum testen von lal-reaktiven stoffen, verfahren zur verwendung und verfahren zur herstellung
EP2906928A4 (de) 2012-10-15 2016-11-09 Nanocellect Biomedical Inc Systeme, vorrichtungen und verfahren zum sortieren von partikeln
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
JP2015078928A (ja) * 2013-10-17 2015-04-23 キヤノン株式会社 流路デバイスおよびその製造方法
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US10335787B2 (en) 2014-10-16 2019-07-02 The General Hospital Corporation Specimen acceptance devices and attachable disposable assay cartridges
EP3209410B1 (de) 2014-10-22 2024-12-25 IntegenX Inc. Elektrophoretische kassette und entsprechendes verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben
EA038479B1 (ru) 2014-12-12 2021-09-03 Опкоу Дайагностикс, Ллк Устройство для проведения анализа пробы и способ эксплуатации указанного устройства
WO2016118812A1 (en) 2015-01-23 2016-07-28 Vanderbilt University A robust interferometer and methods of using same
WO2016161081A1 (en) 2015-04-03 2016-10-06 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
NL1041407B1 (en) * 2015-07-24 2017-02-07 Qmicro B V Microfluidic device.
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US10227556B2 (en) 2015-09-04 2019-03-12 Wayne State University Cell culture devices for biomimetic and pathomimetic cell cultures
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
EP3408649B1 (de) 2016-01-29 2023-06-14 Vanderbilt University Interferometrie mit antwortfunktion in freier lösung
US9739783B1 (en) 2016-03-15 2017-08-22 Anixa Diagnostics Corporation Convolutional neural networks for cancer diagnosis
JP2019520981A (ja) * 2016-06-27 2019-07-25 フルイディック・アナリティクス・リミテッド マイクロ流体デバイスの改良またはマイクロ流体デバイスへの試料充填に関する改良
EP3523032A2 (de) 2016-10-07 2019-08-14 Boehringer Ingelheim Vetmedica GmbH Kartusche zum testen einer probe
US9934364B1 (en) 2017-02-28 2018-04-03 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
US11164082B2 (en) 2017-02-28 2021-11-02 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
US10360499B2 (en) 2017-02-28 2019-07-23 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
US11982611B2 (en) * 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
US11747300B2 (en) * 2018-09-03 2023-09-05 Hitachi High-Tech Corporation Capillary array unit
EP4532107A1 (de) * 2022-06-02 2025-04-09 LUMICKS DSM Holding B.V. Mikrofluidische durchflusszelle
DE102023206781A1 (de) * 2023-07-18 2025-01-23 Robert Bosch Gesellschaft mit beschränkter Haftung Aufnahmeelement für eine mikrofluidische Vorrichtung zum Prozessieren von Fluiden, mikrofluidische Vorrichtung und Verfahren zum Herstellen eines Aufnahmeelements
WO2025122931A1 (en) * 2023-12-07 2025-06-12 ADA Science and Research Institute LLC Devices, kits and methods for sample processing
EP4578547A1 (de) 2023-12-27 2025-07-02 Tecan Trading AG Mikrofluidische vorrichtung für ein laborautomatisierungsgerät
WO2025155942A1 (en) * 2024-01-19 2025-07-24 Grolltex, Inc. Methods and devices for molecular characterization

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3053598A (en) 1960-08-08 1962-09-11 Cheslow Ernest Set of tables
US3785928A (en) * 1971-01-27 1974-01-15 M Kessler Bacteriological titration tray
US3939623A (en) 1973-12-21 1976-02-24 Baxter Laboratories, Inc. Plasma collection system
US4038149A (en) 1975-12-31 1977-07-26 Linbro Scientific, Inc. Laboratory trays with lockable covers
US4252132A (en) 1978-10-10 1981-02-24 Shs Enterprises, Ltd. Midstream urine specimen collecting device
US4390403A (en) 1981-07-24 1983-06-28 Batchelder J Samuel Method and apparatus for dielectrophoretic manipulation of chemical species
US4493815A (en) * 1983-07-28 1985-01-15 Bio-Rad Laboratories, Inc. Supporting and filtering biochemical test plate assembly
US5503803A (en) * 1988-03-28 1996-04-02 Conception Technologies, Inc. Miniaturized biological assembly
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5107987A (en) 1988-11-18 1992-04-28 Palazzolo Frank J Toothbrush holder
DE3904872A1 (de) 1989-02-17 1990-08-23 Gert Schlueter Verfahren und vorrichtung zum sammeln und abtrennen von zellen, partikeln od. dgl. aus koerperfluessigkeit fuer die mikroskopische diagnostik
US5100627A (en) 1989-11-30 1992-03-31 The Regents Of The University Of California Chamber for the optical manipulation of microscopic particles
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5922615A (en) * 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5156285A (en) 1990-06-05 1992-10-20 Colgate-Palmolive Company Easy grip bottle
EP0497077B1 (de) 1991-01-28 1996-07-17 Ciba-Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
US5108603A (en) * 1991-04-04 1992-04-28 Life Technologies, Inc. Self-contained vacuum clamped multi-sample media filtration apparatus and method
EP0544969B1 (de) 1991-12-06 1997-03-05 Ciba-Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
US5635403A (en) 1991-12-13 1997-06-03 Nuclear Fuel Services, Inc. Sample containment card for air or station contamination monitoring system and process
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
ATE140880T1 (de) * 1992-05-01 1996-08-15 Univ Pennsylvania Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5484731A (en) 1993-05-26 1996-01-16 Becton, Dickinson And Company Multiwell in-vitro fertilization plate
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
EP0653631B1 (de) 1993-11-11 2003-05-14 Aclara BioSciences, Inc. Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
JP2937064B2 (ja) * 1995-02-28 1999-08-23 株式会社島津製作所 キャピラリ電気泳動チップ
US5640995A (en) 1995-03-14 1997-06-24 Baxter International Inc. Electrofluidic standard module and custom circuit board assembly
DE19511603A1 (de) * 1995-03-30 1996-10-02 Norbert Dr Ing Schwesinger Vorrichtung zum Mischen kleiner Flüssigkeitsmengen
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
JPH1010088A (ja) * 1996-06-26 1998-01-16 Hitachi Ltd キャピラリ−電気泳動装置
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
JP3361530B2 (ja) 1996-06-28 2003-01-07 カリパー・テクノロジーズ・コープ． 電子ピペッタおよび電気泳動バイアスのための補償手段
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US5964995A (en) 1997-04-04 1999-10-12 Caliper Technologies Corp. Methods and systems for enhanced fluid transport
CA2284612A1 (en) 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
AU727083B2 (en) 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6524790B1 (en) 1997-06-09 2003-02-25 Caliper Technologies Corp. Apparatus and methods for correcting for variable velocity in microfluidic systems
US5882465A (en) * 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5959291A (en) 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
CA2300203A1 (en) 1997-09-02 1999-03-11 Caliper Technologies Corporation Microfluidic system with electrofluidic and electrothermal controls
US6012902A (en) 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US5958343A (en) * 1997-12-29 1999-09-28 Astle; Thomas W. Small volume pipettor
EP1044370B1 (de) 1997-12-30 2017-08-23 Caliper Life Sciences, Inc. Software zur anzeige chromatographischer trenndaten
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers

Also Published As

Publication number Publication date
US6251343B1 (en) 2001-06-26
AU3308199A (en) 1999-09-15
EP1060023B1 (de) 2012-05-09
US6488897B2 (en) 2002-12-03
EP1060023A1 (de) 2000-12-20
US20020127149A1 (en) 2002-09-12
EP2266695A3 (de) 2011-01-05
EP2266695A2 (de) 2010-12-29
WO1999043432A1 (en) 1999-09-02
WO1999043432A9 (en) 2000-03-02
EP1060023A4 (de) 2006-03-15

Similar Documents

Publication Publication Date Title
EP2266695A3 (de) Mikrofluidische Vorrichtungen und Systeme, die Deckschichten integrieren
ATE296681T1 (de) Mikrofluidische analysevorrichtung
WO2002030560A3 (en) Fluidic couplers and modular microfluidic systems
CA2261869A1 (en) Integrated microfluidic devices
TW368679B (en) Modular block assembly using angled fasteners for interconnecting fluid components
WO2000003169A3 (en) Manifold system of removable components for distribution of fluids
ZA200303699B (en) Multiple zone apertured web.
DE69916264D1 (de) Elektrisch regelbares ventil
ATE268642T1 (de) Nachweisgerät mit einer fluid-kontroll- filmschicht mit kapillarkanälen
CA2262808A1 (en) Plug apparatus having a dispersible plug member and a fluid barrier
CA2158858A1 (en) Optical fibre organizer
MY133283A (en) Three circuit plate heat exchanger
WO2003045559A3 (en) Microfluidic devices with distributing inputs
NL1009107A1 (nl) Gelatine-uitspreidende doos met meervoudige, aanpasbare poortklep en meerlagig zacht gel.
MY129103A (en) Absorbent article having multi-layered absorbent member
EP0838596A3 (de) 3- wege Pilot- Transferventil
IT1283482B1 (it) Dispositivo combinato comprendente serbatoio di sangue venoso e cardiotomo in circuito extracorporeo
DE50010393D1 (de) Ventilanordnung
CA2231085A1 (en) Plate and facing assembly
EP0846873A3 (de) Vorgesteuertes Umschaltventil
CA2284637A1 (en) Diaphragm valve
EP0915259A3 (de) Verbindungseinrichtung für ein Wegeventil
DE602004005681D1 (de) Kapillarsperre
DE59403277D1 (de) Ventilstation
ES2165100T3 (es) Cuerpo estratificado con propiedades de fosforescencia, procedimiento para su produccion y su utilizacion.