ATE56865T1 - Verfahren zur herstellung von biologisch abbaubaren mikrokapseln auf basis von serumalbumin. - Google Patents

Verfahren zur herstellung von biologisch abbaubaren mikrokapseln auf basis von serumalbumin.

Info

Publication number
ATE56865T1
ATE56865T1 AT85401087T AT85401087T ATE56865T1 AT E56865 T1 ATE56865 T1 AT E56865T1 AT 85401087 T AT85401087 T AT 85401087T AT 85401087 T AT85401087 T AT 85401087T AT E56865 T1 ATE56865 T1 AT E56865T1
Authority
AT
Austria
Prior art keywords
serum albumin
manufacture
biodegradable microcapsules
microcapsules based
crosslinked
Prior art date
Application number
AT85401087T
Other languages
English (en)
Inventor
Rene Fickat
Simon Benita
Francis Puisieux
Original Assignee
Univ Paris Sud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Paris Sud filed Critical Univ Paris Sud
Application granted granted Critical
Publication of ATE56865T1 publication Critical patent/ATE56865T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT85401087T 1984-06-05 1985-06-03 Verfahren zur herstellung von biologisch abbaubaren mikrokapseln auf basis von serumalbumin. ATE56865T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8408761A FR2565102B1 (fr) 1984-06-05 1984-06-05 Microcapsules biodegradables a base de serumalbumine, leur preparation et leur application a la liberation in situ de medicuments
EP85401087A EP0170540B1 (de) 1984-06-05 1985-06-03 Verfahren zur Herstellung von biologisch abbaubaren Mikrokapseln auf Basis von Serumalbumin

Publications (1)

Publication Number Publication Date
ATE56865T1 true ATE56865T1 (de) 1990-10-15

Family

ID=9304700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85401087T ATE56865T1 (de) 1984-06-05 1985-06-03 Verfahren zur herstellung von biologisch abbaubaren mikrokapseln auf basis von serumalbumin.

Country Status (6)

Country Link
US (1) US4666641A (de)
EP (1) EP0170540B1 (de)
JP (1) JPS6133112A (de)
AT (1) ATE56865T1 (de)
DE (1) DE3579866D1 (de)
FR (1) FR2565102B1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3484332D1 (de) * 1983-02-10 1991-05-02 Matsushita Electric Industrial Co Ltd Porzellanzusammensetzung fuer spannungsabhaengigen nichtlinearen resistor.
US4684524A (en) * 1984-03-19 1987-08-04 Alza Corporation Rate controlled dispenser for administering beneficial agent
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
AU610083B2 (en) * 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4976968A (en) * 1989-02-24 1990-12-11 Clinical Technologies Associates, Inc. Anhydrous delivery systems for pharmacological agents
US4983402A (en) * 1989-02-24 1991-01-08 Clinical Technologies Associates, Inc. Orally administerable ANF
FR2652741B1 (fr) * 1989-10-10 1994-03-04 Laboratoires Care System Composition antimicrobienne pour application sur la peau, applications comme deodorant corporel et bactericide cutane.
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) * 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
EP0627941A1 (de) * 1992-02-28 1994-12-14 ORDER, Stanley E. VERWENDUNG VON AGGREGIERTEN PROTEINEN ZUR VERLäNGERUNG DER VERWEILDAUER EINES WIRKSTOFFES AM ZIELORT; WIE ZUM BEISPIEL BEI EINEM TUMOR
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5981719A (en) * 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
AU6819294A (en) 1993-04-22 1994-11-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6461643B2 (en) * 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
JP2912563B2 (ja) * 1995-03-07 1999-06-28 戸田建設株式会社 地下外壁躯体の鉄筋の配筋方法
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
CN1151836C (zh) 1995-03-31 2004-06-02 艾米斯菲尔技术有限公司 用作传送活性剂的化合物和组合物
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
GB2320248B (en) 1995-09-11 1999-04-14 Emisphere Tech Inc Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones
IL126318A (en) 1996-03-29 2004-09-27 Emisphere Tech Inc Compounds and compositions for delivering active agents and some novel carrier compounds
CA2258264A1 (en) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU7201998A (en) * 1997-05-06 1998-11-27 Zhi Liu Drug delivery system
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
GB0403406D0 (en) * 2004-02-17 2004-03-24 Biotransys Ltd Preparation of carriers for drug delivery and other therapeutic applications
DE102009051575A1 (de) * 2009-10-26 2011-04-28 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verwendung von biokompatiblen Zusammensetzungen und hieraus polymerisierten Materialien zur Inhibierung der Angiogenese
US11590084B2 (en) 2016-05-02 2023-02-28 Roman Bielski Microcapsules for controlled delivery of an active pharmaceutical ingredient
CN110252218B (zh) * 2019-07-18 2021-07-27 广东省医疗器械研究所 蛋白修饰的聚合物微球复合材料、其制备方法及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1059624B (de) * 1954-11-11 1959-06-18 Dr Knut Jacobus Sundman Verfahren zur Herstellung von in einer Traegersubstanz dispergierten Arzneien in dosierter Form
US3137631A (en) * 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US4419340A (en) * 1969-03-24 1983-12-06 University Of Delaware Controlled release of anticancer agents from biodegradable polymers
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4324683A (en) * 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
CA1077842A (en) * 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
US4115534A (en) * 1976-08-19 1978-09-19 Minnesota Mining And Manufacturing Company In vitro diagnostic test
US4251387A (en) * 1979-04-17 1981-02-17 Damon Corporation Process for preparing semipermeable microcapsules
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4349530A (en) * 1980-12-11 1982-09-14 The Ohio State University Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
FR2526328A1 (fr) * 1982-05-04 1983-11-10 Centre Nat Rech Scient Microcapsules a paroi obtenue par reticulation des proteines du lait, et leur procede de preparation
JPH106610A (ja) * 1996-06-25 1998-01-13 Graphtec Corp ラインヘッドの保持位置調整機構

Also Published As

Publication number Publication date
FR2565102B1 (fr) 1987-03-20
EP0170540B1 (de) 1990-09-26
EP0170540A1 (de) 1986-02-05
DE3579866D1 (de) 1990-10-31
JPS6133112A (ja) 1986-02-17
FR2565102A1 (fr) 1985-12-06
US4666641A (en) 1987-05-19

Similar Documents

Publication Publication Date Title
ATE56865T1 (de) Verfahren zur herstellung von biologisch abbaubaren mikrokapseln auf basis von serumalbumin.
DE3851793D1 (de) Verfahren zur Hydrierung von Polymeren.
DE68923319D1 (de) Fluorkohlenstoff- Membranen und Verfahren zur Herstellung von Fluorkohlenstoff-Membranen.
ATE24964T1 (de) Verfahren zur herstellung von festen formgegenstaenden.
DE69022557D1 (de) Verfahren zur Herstellung von Copolyestercarbonaten.
DE3888564D1 (de) Verfahren zur Herstellung von vernetzten Polymerteilchen.
DE3786832D1 (de) Verfahren zur herstellung von immunoglobulinzubereitungen fuer intravenoese injektion.
ATE89595T1 (de) Verfahren fuer die herstellung von brennstoffbriketts.
NL7903456A (nl) Reagens voor de bepaling van hepatitis b alsmede werk- wijze voor de uitvoering daarvan.
DE68906768D1 (de) Verfahren und anlage zur herstellung von gewoelbt gehaerteten automobilscheiben.
DE68913447D1 (de) Verfahren zur Herstellung von Halofluorbenzolen.
DE3872407D1 (de) Verfahren zur herstellung von kohlenstoff-kohlenstoff-verbundmaterialien.
DE59004300D1 (de) Verfahren zur Herstellung von Aldehyden.
DE68910771D1 (de) Verfahren zur Herstellung von verbessertem Proteinhydrolysat.
DE3885262D1 (de) Verfahren zur Herstellung von 2-Chlor-5-methyl-pyridin.
DE69013621D1 (de) Verfahren zur Herstellung von tertiärem Amino-Alkohol.
KR910005885A (ko) 단백질 c의 활성화방법
DE68922714D1 (de) Verfahren zur Herstellung von 2-Phenylbenzotriazolen.
DE68924644D1 (de) Verfahren zur herstellung von polyarylenthioäther.
DE58906820D1 (de) Verfahren zur Herstellung von Aralkylhydroperoxiden.
DE3884113D1 (de) Verfahren zur Herstellung von Pfropfpolymerisaten.
DE68910317D1 (de) Verfahren zur Entfärbung von Alkan- und Arensulfonsäuren.
DE58905592D1 (de) Verfahren zur Herstellung von N-Hydroxypyrazolen.
DE68913694D1 (de) Verfahren zur Herstellung von Glykolaldehyd.
DE69003888D1 (de) Verfahren zur Herstellung von Haloalkylalkanoaten.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee