ATE59046T1 - Bizyklische diphosphonat-verbindungen und arzneimittel. - Google Patents

Bizyklische diphosphonat-verbindungen und arzneimittel.

Info

Publication number: ATE59046T1
Authority: AT; Austria
Prior art keywords: present; bicyclic; pharmaceuticals; relates; compounds
Prior art date: 1986-12-19

Application number

AT87202533T

Other languages

English (en)

Inventor

Frank Hallock Ebetino

Kent Warren Buckingham

Jocelyn Elaine Mcosker

Original Assignee

Norwich Eaton Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-19

Filing date

1987-12-16

Publication date

1990-12-15

1987-12-16 Application filed by Norwich Eaton Pharma filed Critical Norwich Eaton Pharma

1990-12-15 Application granted granted Critical

1990-12-15 Publication of ATE59046T1 publication Critical patent/ATE59046T1/de

Links

XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical class [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 title 1
239000003814 drug Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
239000008194 pharmaceutical composition Substances 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Paints Or Removers (AREA)
Compositions Of Macromolecular Compounds (AREA)
Steroid Compounds (AREA)

AT87202533T 1986-12-19 1987-12-16 Bizyklische diphosphonat-verbindungen und arzneimittel. ATE59046T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/945,069 US4868164A (en)	1986-12-19	1986-12-19	Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
EP87202533A EP0273514B1 (de)	1986-12-19	1987-12-16	Bizyklische Diphosphonat-Verbindungen und Arzneimittel

Publications (1)

Publication Number	Publication Date
ATE59046T1 true ATE59046T1 (de)	1990-12-15

Family

ID=25482572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87202533T ATE59046T1 (de)	1986-12-19	1987-12-16	Bizyklische diphosphonat-verbindungen und arzneimittel.

Country Status (18)

Country	Link
US (3)	US4868164A (de)
EP (1)	EP0273514B1 (de)
JP (1)	JP2573973B2 (de)
KR (1)	KR950009196B1 (de)
AT (1)	ATE59046T1 (de)
AU (1)	AU615886B2 (de)
CA (1)	CA1321793C (de)
DE (1)	DE3766695D1 (de)
DK (1)	DK171068B1 (de)
FI (1)	FI87652C (de)
HK (1)	HK79393A (de)
IE (1)	IE873456L (de)
IL (1)	IL84660A (de)
MY (1)	MY102266A (de)
NO (2)	NO174625C (de)
NZ (1)	NZ222985A (de)
PH (1)	PH25583A (de)
ZA (1)	ZA879502B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4868164A (en) *	1986-12-19	1989-09-19	Norwich Eaton Pharmaceuticals, Inc.	Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
IL86951A (en) *	1987-07-06	1996-07-23	Procter & Gamble Pharma	Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3822650A1 (de) *	1988-07-05	1990-02-01	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5753634A (en) *	1992-05-29	1998-05-19	The Procter & Gamble Company	Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
ES2118967T3 (es) *	1992-05-29	1998-10-01	Procter & Gamble Pharma	Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales.
US5391743A (en) *	1992-05-29	1995-02-21	Procter & Gamble Pharmaceuticals, Inc.	Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
EP0642521A1 (de) *	1992-05-29	1995-03-15	Procter & Gamble Pharmaceuticals	Thio-substituierte stickstoff-enthaltende heterozyclische phosphonat-verbindungen zur behandlung von abnormalem calzium-und phosphat-metabolismus
US5763611A (en) *	1992-05-29	1998-06-09	The Procter & Gamble Company	Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
HUT69699A (en) *	1992-05-29	1995-09-28	Procter & Gamble Pharma	Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism
NZ253631A (en) *	1992-06-30	1997-02-24	Procter & Gamble Pharma	Phosphonate or nsaid pharmaceutical compositions for treating arthritis
CA2199252A1 (en) *	1994-09-09	1996-03-14	Ann Dunbar Geddes	Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone
EP0753523A1 (de)	1995-07-10	1997-01-15	Gador S.A.	Amino-substuierte bisphosphonsäure
US7781418B2 (en) *	2006-12-14	2010-08-24	Isis Innovation Ltd.	Composition for treating bone disorders
US11793452B2 (en)	2019-10-03	2023-10-24	Johnson & Johnson Consumer Inc.	Method of visualizing and quantifying remineralization

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3553314A (en) *	1968-12-23	1971-01-05	Procter & Gamble	Oral compositions for calculus retardation
US3979385A (en) *	1969-11-19	1976-09-07	Henkel & Cie G.M.B.H.	1-Aminoalkane-1,1-diphosphonic acids and their salts
DE1958123C3 (de) *	1969-11-19	1978-09-28	Henkel Kgaa, 4000 Duesseldorf	Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen
US3683080A (en) *	1970-08-28	1972-08-08	Procter & Gamble	Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US3899496A (en) *	1970-10-06	1975-08-12	Henkel & Cie Gmbh	Production of 1-aminoalkane-1,1-diphosphonic acids
DE2104476C2 (de) *	1971-02-01	1983-12-01	Henkel KGaA, 4000 Düsseldorf	Verfahren zur Verhinderung von Ausfällungen in Wasser oder wäßrigen Lösungen
DE2343147C2 (de) *	1973-08-27	1982-06-09	Henkel KGaA, 4000 Düsseldorf	Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung
DE2343196C3 (de) *	1973-08-27	1980-01-10	Henkel Kgaa, 4000 Duesseldorf	Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze
US4034086A (en) *	1973-08-27	1977-07-05	Henkel & Cie G.M.B.H.	Pyrrolidone-5,5-diphosphonic acids
US3988443A (en) *	1973-08-27	1976-10-26	Henkel & Cie G.M.B.H.	Azacycloalkane-2,2-diphosphonic acids
DE2456666A1 (de) *	1974-11-30	1976-08-12	Henkel & Cie Gmbh	Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse
DE2543349C2 (de) *	1975-09-29	1984-05-10	Henkel KGaA, 4000 Düsseldorf	Preaparate zur herstellung von99m technetium-radiagnostica
DK506476A (da) *	1975-12-01	1977-06-02	Henkel & Cie Gmbh	Farmaceutiske preparater til behandling af calciumstofs skifteforstyrrelser
DE2745083C2 (de) *	1977-10-07	1985-05-02	Henkel KGaA, 4000 Düsseldorf	Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
US4230700A (en) *	1977-12-07	1980-10-28	The Procter & Gamble Company	Methods for inhibiting mobilization of calcium phosphate in animal tissue
SU1002300A1 (ru) *	1981-10-29	1983-03-07	Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова	Способ получени @ -аминозамещенных- @ -оксипропилидендифосфоновых кислот
DE3428524A1 (de) *	1984-08-02	1986-02-13	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4687768A (en) *	1984-12-21	1987-08-18	The Procter & Gamble Company	Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
DE3540150A1 (de) *	1985-11-13	1987-05-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4868164A (en) *	1986-12-19	1989-09-19	Norwich Eaton Pharmaceuticals, Inc.	Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism

1986
- 1986-12-19 US US06/945,069 patent/US4868164A/en not_active Expired - Lifetime
1987
- 1987-11-30 IL IL8466087A patent/IL84660A/en not_active IP Right Cessation
- 1987-12-10 MY MYPI87003173A patent/MY102266A/en unknown
- 1987-12-16 AT AT87202533T patent/ATE59046T1/de not_active IP Right Cessation
- 1987-12-16 DE DE8787202533T patent/DE3766695D1/de not_active Expired - Fee Related
- 1987-12-16 EP EP87202533A patent/EP0273514B1/de not_active Expired - Lifetime
- 1987-12-17 CA CA000554628A patent/CA1321793C/en not_active Expired - Fee Related
- 1987-12-18 DK DK670387A patent/DK171068B1/da not_active IP Right Cessation
- 1987-12-18 AU AU82809/87A patent/AU615886B2/en not_active Ceased
- 1987-12-18 NO NO875305A patent/NO174625C/no not_active IP Right Cessation
- 1987-12-18 PH PH36260A patent/PH25583A/en unknown
- 1987-12-18 ZA ZA879502A patent/ZA879502B/xx unknown
- 1987-12-18 IE IE873456A patent/IE873456L/xx not_active IP Right Cessation
- 1987-12-18 NZ NZ222985A patent/NZ222985A/xx unknown
- 1987-12-18 FI FI875595A patent/FI87652C/fi not_active IP Right Cessation
- 1987-12-19 JP JP62322651A patent/JP2573973B2/ja not_active Expired - Fee Related
- 1987-12-19 KR KR1019870014561A patent/KR950009196B1/ko not_active Expired - Fee Related
1989
- 1989-09-14 US US07/407,848 patent/US5137880A/en not_active Expired - Lifetime
1992
- 1992-06-17 US US07/899,794 patent/US5393746A/en not_active Expired - Fee Related
- 1992-06-29 NO NO922565A patent/NO176144C/no not_active IP Right Cessation
1993
- 1993-08-05 HK HK793/93A patent/HK79393A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI875595A7 (fi)	1988-06-20
NO922565D0 (no)	1992-06-29
CA1321793C (en)	1993-08-31
FI87652B (fi)	1992-10-30
IL84660A (en)	1994-10-21
NO174625C (no)	1994-06-08
US5137880A (en)	1992-08-11
ZA879502B (en)	1988-06-16
NO176144C (no)	1995-02-08
EP0273514A1 (de)	1988-07-06
DE3766695D1 (de)	1991-01-24
AU615886B2 (en)	1991-10-17
EP0273514B1 (de)	1990-12-12
US5393746A (en)	1995-02-28
DK670387D0 (da)	1987-12-18
HK79393A (en)	1993-08-13
NZ222985A (en)	1990-09-26
NO875305L (no)	1988-06-20
AU8280987A (en)	1988-06-23
MY102266A (en)	1992-05-15
FI875595A0 (fi)	1987-12-18
NO176144B (no)	1994-10-31
JP2573973B2 (ja)	1997-01-22
PH25583A (en)	1991-08-08
DK670387A (da)	1988-06-20
KR950009196B1 (ko)	1995-08-16
FI87652C (fi)	1993-02-10
NO875305D0 (no)	1987-12-18
IE873456L (en)	1988-06-19
DK171068B1 (da)	1996-05-20
JPS63239290A (ja)	1988-10-05
KR880007473A (ko)	1988-08-27
NO922565L (no)	1988-06-20
US4868164A (en)	1989-09-19
NO174625B (no)	1994-02-28
IL84660A0 (en)	1988-04-29

Legal Events

Date	Code	Title	Description
1991-10-15	UEP	Publication of translation of european patent specification
2002-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU583873B2 (en)	1989-05-11	Novel diphosphonates
AU1876788A (en)	1989-01-12	Methylene phosphonoalkylphosphinates, pharmaceutical compositions , and methods for treating abnormal calcium and phosphate metabolism
LU90669I2 (fr)	2001-01-10	Actonel
DE3766695D1 (de)	1991-01-24	Bizyklische diphosphonat-verbindungen und arzneimittel.
MY103850A (en)	1993-09-30	Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
DE3789436D1 (de)	1994-04-28	Heteroring-substituierte Diphosphonatverbindungen, Arzneimittel und Verfahren zur Behandlung von abnormalen Kalzium- und Phosphatmetabolismen.
ES8609312A1 (es)	1986-09-01	Procedimiento para la preparacion de silibinina exenta de isosilibina
FR2357551A1 (fr)	1978-02-03	Nouvelles 2,5-dideoxystreptamines et leur procede de preparation
DE3660959D1 (de)	1988-11-24	Benz-trisubstituted 2-aminotetralins