ATE59652T1 - AVERMECTIN AND MILBEMYCIN DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE. - Google Patents
AVERMECTIN AND MILBEMYCIN DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE.Info
- Publication number
- ATE59652T1 ATE59652T1 AT86305604T AT86305604T ATE59652T1 AT E59652 T1 ATE59652 T1 AT E59652T1 AT 86305604 T AT86305604 T AT 86305604T AT 86305604 T AT86305604 T AT 86305604T AT E59652 T1 ATE59652 T1 AT E59652T1
- Authority
- AT
- Austria
- Prior art keywords
- double bond
- avermectin
- absent
- alpha
- alkyl
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 3
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 3
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Chemical class COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 ISOPROPYL Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000000642 acaricide Substances 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 229940124339 anthelmintic agent Drugs 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 229940125687 antiparasitic agent Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000013057 ectoparasiticide Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
THE INVENTION PROVIDES NOVEL COMPOUNDS HAVING THE FORMULA:(FORMULA 1)WHEREIN THE BROKEN LINE AT THE 22-23 POSITION REPRESENTS AN OPTIONAL DOUBLE BOND AND WHEREIN R1 IS H OR OH AND THE DOUBLE BOND IS ABSENT, OR, THE DOUBLE BOND IS PRESENT AND R1 IS ABSENT; R2 IS AN ALPHA-BRANCHED C3-C8 ALKYL, ALKENYL, ALKYNYL, ALKOXYALKYL OR ALKYLTHIOALKYL GROUP; A C3-C8 CYCLOALKYL, C5-C8 CYCLOALKENYL OR C5-C8 CYCLOALKYLALKYL GROUP, ANY OF WHICH MAY OPTIONALLY BE SUBSTITUTED BY METHYLENE OR ONE OR MORE C1-C4 ALKYL GROUPS OR HALO ATOMS; OR A 3 TO 6 MEMBERED OXYGEN OR SULPHUR CONTAINING HETEROCYCLIC RING WHICH MAY OPTIONALLY BE SUBSTITUTED BY ONE OR MORE C1-C4 ALKYL GROUPS OR HALO ATOMS; R3 IS HYDROGEN OR METHYL; R4 IS H OR 4''-(ALPHA-L-OLEANDROSYL)-ALPHA-L-OLEANDROSYLOXY, WITH THE PROVISO THAT WHEN R2 IS ALKYL IT IS NOT ISOPROPYL OR SEC-BUTYL, AND WHEN R4 IS H, R1 IS OH, AND THE DOUBLE BOND IS ABSENT, R2 IS NOT 2-BUTEN-2-YL,, 2-PENTENE-2-YL OR 4-METHYL-2-PENTENE-2-YL. THE COMPOUNDS ARE BROAD SPECTRUM ANTIPARASITIC AGENTS HAVING UTILITY AS ANTHELMINTICS, ECTOPARASITICIDES, INSECTICIDES AND ACARICIDES. THE INVENTION ALSO PROVIDES A PROCESS FOR PRODUCING THE NOVEL AVERMECTIN AND MILBEMYCIN DERIVATIVES BY ADDING A CARBOXYLIC ACID OR DERIVATIVE THEREOF TO A FERMENTATION OF AN AVERMECTIN OR MILBEMYCIN PRODUCING ORGANISM.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858518999A GB8518999D0 (en) | 1985-07-27 | 1985-07-27 | Antiparasitic agents |
| GB858520069A GB8520069D0 (en) | 1985-08-09 | 1985-08-09 | Anti-parasitic agents |
| GB868610063A GB8610063D0 (en) | 1986-04-24 | 1986-04-24 | Antiparasitic agents |
| GB868610862A GB8610862D0 (en) | 1986-05-02 | 1986-05-02 | Antiparasitic agents |
| EP86305604A EP0214731B1 (en) | 1985-07-27 | 1986-07-22 | Antiparasitic avermectin and milbemycin derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE59652T1 true ATE59652T1 (en) | 1991-01-15 |
Family
ID=27513440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86305604T ATE59652T1 (en) | 1985-07-27 | 1986-07-22 | AVERMECTIN AND MILBEMYCIN DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE. |
Country Status (3)
| Country | Link |
|---|---|
| AT (1) | ATE59652T1 (en) |
| CS (1) | CS354391A3 (en) |
| MY (1) | MY101771A (en) |
-
1986
- 1986-07-22 AT AT86305604T patent/ATE59652T1/en active
-
1987
- 1987-07-25 MY MYPI87001126A patent/MY101771A/en unknown
-
1991
- 1991-11-22 CS CS913543A patent/CS354391A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY101771A (en) | 1992-01-17 |
| CS354391A3 (en) | 1992-08-12 |
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