ATE60055T1 - Verfahren zur herstellung von n-methyl-lysergol. - Google Patents

Verfahren zur herstellung von n-methyl-lysergol.

Info

Publication number: ATE60055T1
Authority: AT; Austria
Prior art keywords: lysergol; methyl; production; alpha; methyllysergol
Prior art date: 1985-07-11

Application number

AT86401539T

Other languages

English (en)

Inventor

Christian Gervais

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-11

Filing date

1986-07-10

Publication date

1991-02-15

1986-07-10 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1991-02-15 Application granted granted Critical

1991-02-15 Publication of ATE60055T1 publication Critical patent/ATE60055T1/de

Links

QVNZRXQLMGMTJF-BDJLRTHQSA-N [(6ar,9r)-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-yl]methanol Chemical compound C1=CC(C2=C[C@@H](CO)CN([C@@H]2C2)C)=C3C2=CN(C)C3=C1 QVNZRXQLMGMTJF-BDJLRTHQSA-N 0.000 title 1
BIXJFIJYBLJTMK-UHFFFAOYSA-N Lysergol Natural products C1=CC(C2=CC(CO)CN(C2C2)C)=C3C2=CNC3=C1 BIXJFIJYBLJTMK-UHFFFAOYSA-N 0.000 abstract 1
BIXJFIJYBLJTMK-MEBBXXQBSA-N lysergol Chemical compound C1=CC(C2=C[C@@H](CO)CN([C@@H]2C2)C)=C3C2=CNC3=C1 BIXJFIJYBLJTMK-MEBBXXQBSA-N 0.000 abstract 1
239000012022 methylating agents‎ Substances 0.000 abstract 1
239000003880 polar aprotic solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT86401539T 1985-07-11 1986-07-10 Verfahren zur herstellung von n-methyl-lysergol. ATE60055T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8510621A FR2584719B1 (fr)	1985-07-11	1985-07-11	Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol
EP86401539A EP0209456B1 (de)	1985-07-11	1986-07-10	Verfahren zur Herstellung von N-Methyl-Lysergol

Publications (1)

Publication Number	Publication Date
ATE60055T1 true ATE60055T1 (de)	1991-02-15

Family

ID=9321196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86401539T ATE60055T1 (de)	1985-07-11	1986-07-10	Verfahren zur herstellung von n-methyl-lysergol.

Country Status (11)

Country	Link
US (1)	US4908449A (de)
EP (1)	EP0209456B1 (de)
JP (1)	JPH0667934B2 (de)
KR (1)	KR930010498B1 (de)
AT (1)	ATE60055T1 (de)
CA (1)	CA1246553A (de)
DE (1)	DE3676899D1 (de)
ES (1)	ES2000331A6 (de)
FR (1)	FR2584719B1 (de)
GR (1)	GR861783B (de)
PT (1)	PT82935B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH674367A5 (de) *	1987-06-16	1990-05-31	Arysearch Arylan Ag
US5707949A (en) *	1996-04-04	1998-01-13	E. I. Du Pont De Nemours And Company	Prevention of dye-bleeding and transfer during laundering
FR2786099B1 (fr)	1998-11-24	2000-12-29	Aventis Laboratoire	Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3228943A (en) *	1962-06-11	1966-01-11		Lumilysergol derivatives
US3183234A (en) *	1963-11-21	1965-05-11	Lilly Co Eli	Octahydroindoloquinolines
FR1440188A (fr) *	1964-04-28	1966-05-27	Sandoz Sa	Nouveaux dérivés de l'ergolène et leur préparation
US3580916A (en) *	1969-02-20	1971-05-25	Lilly Co Eli	Hydroxyesters of hexa- and octahydroindoloquinolines
US3879554A (en) *	1970-03-20	1975-04-22	Farmaceutici Italia	Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
IT1094965B (it) *	1978-04-05	1985-08-10	Corvi Mora E	Procedimento di preparazione di derivati del lisergolo
FR2584720B1 (fr) *	1985-07-11	1987-10-02	Rhone Poulenc Sante	Procede de preparation de derives n-methyles de l'ergoline
US4772709A (en) *	1985-10-01	1988-09-20	Eli Lilly And Company	Process of making ketoalkanol esters of dihydrolysergic acid
US4734501A (en) *	1985-10-01	1988-03-29	Eli Lilly And Company	N-alkylation of dihydrolysergic acid
CH674367A5 (de) *	1987-06-16	1990-05-31	Arysearch Arylan Ag

1985
- 1985-07-11 FR FR8510621A patent/FR2584719B1/fr not_active Expired
1986
- 1986-07-07 PT PT82935A patent/PT82935B/pt not_active IP Right Cessation
- 1986-07-09 CA CA000513402A patent/CA1246553A/fr not_active Expired
- 1986-07-09 GR GR861783A patent/GR861783B/el unknown
- 1986-07-10 AT AT86401539T patent/ATE60055T1/de not_active IP Right Cessation
- 1986-07-10 EP EP86401539A patent/EP0209456B1/de not_active Expired - Lifetime
- 1986-07-10 KR KR1019860005572A patent/KR930010498B1/ko not_active Expired - Fee Related
- 1986-07-10 JP JP61160971A patent/JPH0667934B2/ja not_active Expired - Fee Related
- 1986-07-10 DE DE8686401539T patent/DE3676899D1/de not_active Expired - Fee Related
- 1986-07-11 ES ES8600252A patent/ES2000331A6/es not_active Expired
1989
- 1989-03-27 US US07/329,387 patent/US4908449A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH0667934B2 (ja)	1994-08-31
EP0209456A1 (de)	1987-01-21
EP0209456B1 (de)	1991-01-16
KR930010498B1 (ko)	1993-10-25
PT82935B (pt)	1989-01-30
GR861783B (en)	1986-11-10
DE3676899D1 (de)	1991-02-21
PT82935A (fr)	1986-08-01
KR870001207A (ko)	1987-03-12
CA1246553A (fr)	1988-12-13
FR2584719B1 (fr)	1987-10-02
FR2584719A1 (fr)	1987-01-16
US4908449A (en)	1990-03-13
JPS6236379A (ja)	1987-02-17
ES2000331A6 (es)	1988-02-16

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Legal Events

Date	Code	Title	Description
1991-10-15	UEP	Publication of translation of european patent specification
2005-04-15	REN	Ceased due to non-payment of the annual fee