ATE617T1 - STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS. - Google Patents

STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS.

Info

Publication number
ATE617T1
ATE617T1 AT79101578T AT79101578T ATE617T1 AT E617 T1 ATE617 T1 AT E617T1 AT 79101578 T AT79101578 T AT 79101578T AT 79101578 T AT79101578 T AT 79101578T AT E617 T1 ATE617 T1 AT E617T1
Authority
AT
Austria
Prior art keywords
radioimmunoassays
steroid
processes
production
application
Prior art date
Application number
AT79101578T
Other languages
German (de)
Inventor
Ravi K. Varma
Sam T. Chao
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Application granted granted Critical
Publication of ATE617T1 publication Critical patent/ATE617T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Steroid Compounds (AREA)

Abstract

Radiolabeled steroid derivatives having the formula <IMAGE> wherein St is a 6-dehydro derivative of a 3-oxo-4,5-dehydro steroid intended for radioimmunoassay, said steroid being saturated in the 1,2-position; R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioimmunoassays. The unlabeled analogs can be coupled with an immunogenic carrier and used to induce antibody formation in animals.
AT79101578T 1978-05-22 1979-05-22 STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS. ATE617T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/908,294 US4323511A (en) 1978-05-22 1978-05-22 Steroid derivatives and their use in radioimmunoassays
EP79101578A EP0005558B1 (en) 1978-05-22 1979-05-22 Steroid derivatives, process for their preparation and their use in radioimmunoassays

Publications (1)

Publication Number Publication Date
ATE617T1 true ATE617T1 (en) 1982-02-15

Family

ID=25425538

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101578T ATE617T1 (en) 1978-05-22 1979-05-22 STEROID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR APPLICATION IN RADIOIMMUNOASSAYS.

Country Status (9)

Country Link
US (1) US4323511A (en)
EP (1) EP0005558B1 (en)
JP (1) JPS54151959A (en)
AT (1) ATE617T1 (en)
AU (1) AU523079B2 (en)
CA (1) CA1142915A (en)
DE (1) DE2961949D1 (en)
IL (1) IL57303A0 (en)
ZA (1) ZA791923B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243608A (en) * 1979-05-14 1981-01-06 E. R. Squibb & Sons, Inc. 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs
FR2537586A1 (en) * 1982-12-13 1984-06-15 Roussel Uclaf IODE BRANCHED RADIOACTIVE ESTRATRIENE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION TO RADIOIMMUNOLOGICAL ASSAYS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1118409A (en) * 1977-08-12 1982-02-16 Jack Bernstein Steroid derivatives and their use in radioimmunoassays

Also Published As

Publication number Publication date
US4323511A (en) 1982-04-06
EP0005558A1 (en) 1979-11-28
AU523079B2 (en) 1982-07-08
DE2961949D1 (en) 1982-03-11
CA1142915A (en) 1983-03-15
JPS54151959A (en) 1979-11-29
AU4641479A (en) 1979-11-29
ZA791923B (en) 1980-04-30
EP0005558B1 (en) 1982-01-27
IL57303A0 (en) 1979-09-30

Similar Documents

Publication Publication Date Title
ATE295T1 (en) VITAMIN B12 DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE IN RADIOIMMUNE TESTING.
KR830001868A (en) Method for preparing 1-aryl-2-acylamido-3-fluoro-1-propanol
IL56288A (en) 15-deoxy-16-hydroxy-2-decarboxy-2-hydroxymethylprostaglandin derivatives and their preparation
ES508735A0 (en) &#34;PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF (2-HALOGEN-ERGOLINIL) -N &#39;, N&#39;-DIETHYLUREA&#34;.
KR830002722A (en) Method for preparing imidazolidine derivatives
GB2002385A (en) Steroid hemiesters and their use in radioimmunoassays
GR3005135T3 (en)
AU523079B2 (en) Steroid derivatives and their use in radioimmunoassays
SE7704616L (en) WAY TO PRODUCE NEW 11-DESOXY-PROSTAGLANDIN-FŸ2-DERIVATIVES
SE7713704L (en) PROPIONIC ACID DERIVATIVES AND METHODS FOR THE PREPARATION OF THE SAME
PT77208B (en) NEW THIENO THIENO DERIVATIVES PROCESS FOR THEIR MANUFACTURE AND CONTAINING THESE CONNECTIONS
KR850004470A (en) Process for preparing organic compound
KR840009282A (en) Method for preparing styrene derivative
KR830005225A (en) Method for preparing piperazine derivatives of deophylline
KR850002979A (en) New Preparation Method of 1,2,3-Trithian Compound
GB2003480A (en) Digoxigenin derivatives
SE7811761L (en) 4,5,6,7-TETRAHYDROIMIDAZO- (4,5-C), PYRIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
ATE44742T1 (en) PROCESS FOR THE MANUFACTURE OF ERGOLINE N-METHYL DERIVATIVES.
DE3268984D1 (en) Imidazolylcarboxylic acids, their derivatives and production
KR900003171A (en) Radioiodinated Benzodiazepines Derivatives
ES460117A1 (en) PROCEDURE FOR THE PREPARATION OF NEW N-BENCIL-AMINOA-CIDES CONTAINING SULFUR.
GB1536195A (en) 3-phenyl-sec-butylamine derivatives
SE7901316L (en) DERIVATIVES OF DEHYDROCYCLICIMINIC ACIDS
ES460297A1 (en) 6,11-dihydrodibenzo-(b. e.)-thiepin-11-one-3-aldehyde and 3-acetal derivatives
KR870003047A (en) Method for preparing benzoic acid derivative

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee