ATE62676T1 - Pyridinverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel. - Google Patents

Pyridinverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel.

Info

Publication number: ATE62676T1
Authority: AT; Austria
Prior art keywords: sub; phenyl; alkyl; alkylene; processes
Prior art date: 1985-07-19

Application number

AT86305421T

Other languages

English (en)

Inventor

Hitoshi Uno

Yoshinori Nishikawa

Tokuhiko Shindo

Hideo Nakamura

Katsumi Ishii

Original Assignee

Dainippon Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-19

Filing date

1986-07-15

Publication date

1991-05-15

1986-07-15 Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co

1991-05-15 Application granted granted Critical

1991-05-15 Publication of ATE62676T1 publication Critical patent/ATE62676T1/de

Links

238000000034 method Methods 0.000 title abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
-1 R<sub>7</sub> is H Chemical group 0.000 abstract 4
125000002947 alkylene group Chemical group 0.000 abstract 3
230000002401 inhibitory effect Effects 0.000 abstract 2
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001387 anti-histamine Effects 0.000 abstract 1
239000000739 antihistaminic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

AT86305421T 1985-07-19 1986-07-15 Pyridinverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel. ATE62676T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP16078385		1985-07-19
EP86305421A EP0210782B1 (de)	1985-07-19	1986-07-15	Pyridinverbindungen, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Publications (1)

Publication Number	Publication Date
ATE62676T1 true ATE62676T1 (de)	1991-05-15

Family

ID=15722351

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86305421T ATE62676T1 (de)	1985-07-19	1986-07-15	Pyridinverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel.

Country Status (8)

Country	Link
US (1)	US4778796A (de)
EP (1)	EP0210782B1 (de)
JP (1)	JPS62103065A (de)
KR (1)	KR940003755B1 (de)
AT (1)	ATE62676T1 (de)
CA (1)	CA1262726A (de)
DE (1)	DE3678763D1 (de)
ES (1)	ES2000534A6 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988005435A1 (fr) *	1987-01-20	1988-07-28	Dainippon Pharmaceutical Co., Ltd.	Derives d'amides aromatiques heterocycliques de l'acide carboxylique, procedes de preparation et composition pharmaceutique les contenant
US4788206A (en) *	1987-07-10	1988-11-29	Hoffmann-La Roche Inc.	Pentadieneamides
ES2027897A6 (es) *	1991-01-24	1992-06-16	Espanola Prod Quimicos	Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina.
ES2162792T3 (es) *	1991-09-18	2002-01-16	Glaxo Group Ltd	Derivados de benzanilida como antagonistas de 5-ht1d.
GB9119920D0 (en) *	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds
GB9119932D0 (en) *	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds
ES2046107B1 (es) *	1992-03-05	1994-08-01	Espanola Prod Quimicos	Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina.
PL321003A1 (en) *	1994-12-23	1997-11-24	Thomae Gmbh Dr K	Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
DE19624668A1 (de) *	1996-06-20	1998-02-19	Klinge Co Chem Pharm Fab	Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
DE19624704A1 (de)	1996-06-20	1998-01-08	Klinge Co Chem Pharm Fab	Neue Pyridylalkansäureamide
US6451816B1 (en)	1997-06-20	2002-09-17	Klinge Pharma Gmbh	Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624659A1 (de)	1996-06-20	1998-01-08	Klinge Co Chem Pharm Fab	Neue Pyridylalken- und Pyridylalkinsäureamide
IL125658A0 (en) *	1997-08-18	1999-04-11	Hoffmann La Roche	Ccr-3 receptor antagonists
US6339087B1 (en) *	1997-08-18	2002-01-15	Syntex (U.S.A.) Llc	Cyclic amine derivatives-CCR-3 receptor antagonists
DE19756212A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756236A1 (de) *	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756261A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
US6903118B1 (en)	1997-12-17	2005-06-07	Klinge Pharma Gmbh	Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756235A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
EP1031564A1 (de)	1999-02-26	2000-08-30	Klinge Pharma GmbH	Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie
HUP0103987A3 (en) *	2001-09-28	2004-11-29	Richter Gedeon Vegyeszet	Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
EP1348434A1 (de) *	2002-03-27	2003-10-01	Fujisawa Deutschland GmbH	Verwendung von Pyridylamiden als Inhibitoren von Angiogenese
EP1939180A1 (de)	2006-12-20	2008-07-02	sanofi-aventis	Heteroarylacrylamide und ihre Verwendung als Arzneimittel für die Stimulation der Expression der endothelialen NO-Synthase
ES2954991T3 (es)	2011-07-29	2023-11-28	Karyopharm Therapeutics Inc	Moduladores del transporte nuclear que contienen hidrazida y usos de los mismos
CA2842364A1 (en) *	2011-07-29	2013-02-07	Karyopharm Therapeutics, Inc.	Nuclear transport modulators and uses thereof
SMT202000347T1 (it)	2012-05-09	2020-07-08	Biogen Ma Inc	Modulatori di trasporto nucleare e loro usi
WO2014144772A1 (en)	2013-03-15	2014-09-18	Karyopharm Therapeutics Inc.	Methods of promoting wound healing using crm1 inhibitors
PL3010892T3 (pl)	2013-06-21	2019-07-31	Karyopharm Therapeutics, Inc.	1,2,4-triazole jako modulatory transportu jądrowego i ich zastosowania
CN111484483B (zh)	2014-08-15	2023-05-26	卡尔约药物治疗公司	赛灵克斯的多晶型物
EP3397633A1 (de)	2015-12-31	2018-11-07	Karyopharm Therapeutics, Inc.	Nukleartransportmodulatoren und verwendungen davon
EP3397634A1 (de)	2015-12-31	2018-11-07	Karyopharm Therapeutics, Inc.	Nukleartransportmodulatoren und verwendungen davon
US11602530B2 (en)	2016-11-28	2023-03-14	Biogen Ma Inc.	CRM1 inhibitors for treating epilepsy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1279843A (en) *	1969-05-23	1972-06-28	Science Union & Cie	Benzamidoethyl-piperazines and process for their preparation
NL8005133A (nl) *	1980-09-12	1982-04-01	Duphar Int Res	Fenylpiperazinederivaten met antiagressieve werking.
ZA825719B (en) *	1981-09-03	1983-06-29	Recordati Chem Pharm	Alkanoylanilides

1986
- 1986-07-11 US US06/884,717 patent/US4778796A/en not_active Expired - Fee Related
- 1986-07-14 CA CA000513710A patent/CA1262726A/en not_active Expired
- 1986-07-15 DE DE8686305421T patent/DE3678763D1/de not_active Expired - Lifetime
- 1986-07-15 AT AT86305421T patent/ATE62676T1/de active
- 1986-07-15 EP EP86305421A patent/EP0210782B1/de not_active Expired - Lifetime
- 1986-07-18 ES ES8600423A patent/ES2000534A6/es not_active Expired
- 1986-07-19 JP JP61170458A patent/JPS62103065A/ja active Granted
- 1986-07-19 KR KR1019860005867A patent/KR940003755B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE3678763D1 (de)	1991-05-23
US4778796A (en)	1988-10-18
KR870001196A (ko)	1987-03-12
ES2000534A6 (es)	1988-03-01
EP0210782A3 (en)	1989-03-29
JPH0233705B2 (de)	1990-07-30
EP0210782B1 (de)	1991-04-17
EP0210782A2 (de)	1987-02-04
KR940003755B1 (ko)	1994-04-30
JPS62103065A (ja)	1987-05-13
CA1262726A (en)	1989-11-07

Publication	Publication Date	Title
ATE62676T1 (de)	1991-05-15	Pyridinverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel.
MA27365A1 (fr)	2005-06-01	Derives de spiro-indolinepiperidine
CA2160444A1 (en)	1996-04-15	Aroyl-piperdine derivatives
YU155290A (sh)	1993-05-28	Dusikove spojine
NZ219193A (en)	1989-01-06	Piperazinyl pyridines and piperinyl-imidazoles and pharmaceutical compositions; intermediates
DE69725978D1 (de)	2003-12-11	Chalcon-derivate und medikamente die diese enthalten
FI954898A0 (fi)	1995-10-13	Vesiliukoiset kamptotesiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö kasvaintenvastaisina aineina
PT82569A (fr)	1986-06-01	Procede de preparation de derives de (benzolyl-4 piperidino)-2 phenyl-1 alcanols et de compositions pharmaceutiques les contenant
FR2667068B1 (fr)	1994-09-09	Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
LU88317I2 (fr)	1994-05-04	Chlorhydrate d'esmolol (Brevibloc)
BE890509A (fr)	1982-03-25	Halogenures d'ammonium spiro-quaternaire, leur procede de preparation et leur utilisation dans un procede de production de n-(2-pyrimidinyl)piperazinyl-alkylazospiro-alcanediones
EP1228072A4 (de)	2003-05-07	Pdgf-rezeptor-kinase hemmende verbindungen, deren herstellung, reinigung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE22891T1 (de)	1986-11-15	Pyrimidinonderivate und diese enthaltende pharmazeutische zusammensetzungen.
EP0210078A3 (de)	1988-11-09	Cephalosporinverbindungen
KR950025039A (ko)	1995-09-15	신규의 치환된 피리딘 이미다졸 유도체 및 그의 제조방법
ATE38987T1 (de)	1988-12-15	Neue 2h-1-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten.
EA200000389A3 (ru)	2001-02-26	Новые замещенные пиридины или пиперидины, способ их получения и содержащие их фармацевтические композиции
DE3216843A1 (de)	1983-11-17	Thiomethylpyridin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0173377A3 (de)	1986-12-30	Pyrimidinonverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
FR2766487B1 (fr)	1999-08-27	Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
MY136928A (en)	2008-11-28	New isoquinoline compounds, a process for their preparation and pharmaceutical composition containing them
EP0316939A3 (de)	1990-12-05	Biphenyl-Derivate, Verfahren zur Herstellung, sie enthaltende pharmazeutische Zusammensetzungen und Verwendung
IE49619B1 (en)	1985-11-13	A method for controlling ectoparasitic acarina using 2-aryl-1,3-indandione derivatives and compositions containing them
JPS5756425A (en)	1982-04-05	Hypotensor
ATE4422T1 (de)	1983-08-15	Substituierte 5-((7-chlor-4-chinolinyl)amino)-3(aminomethyl)-(1,1'-biphenyl)-2-ol-verbindungen verfahren zu ihrer herstellung; und die verbindungen enthaltende pharmazeutische zusammensetzungen.