ATE66490T1 - INSULIN PRECURSORS, PROCEDURES FOR THEIR PREPARATION AND PROCESSES FOR THE PREPARATION OF HUMAN INSULIN FROM SUCH INSULIN PRECURSORS. - Google Patents

INSULIN PRECURSORS, PROCEDURES FOR THEIR PREPARATION AND PROCESSES FOR THE PREPARATION OF HUMAN INSULIN FROM SUCH INSULIN PRECURSORS.

Info

Publication number: ATE66490T1
Authority: AT; Austria
Prior art keywords: insulin; preparation; precursors; procedures; processes
Prior art date: 1984-05-30

Application number

AT85303775T

Other languages

German (de)

Inventor

Jan Markussen

Niels Fiil

Gustav Ammerer

Mogens Trier Hansen

Lars Thim

Kjeld Norris

Hans Ole Voigt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-30

Filing date

1985-05-29

Publication date

1991-09-15

1984-05-30 Priority claimed from DK266584A external-priority patent/DK266584D0/en

1985-02-08 Priority claimed from DK58285A external-priority patent/DK58285D0/en

1985-05-29 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1991-09-15 Application granted granted Critical

1991-09-15 Publication of ATE66490T1 publication Critical patent/ATE66490T1/en

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 4
102000004877 Insulin Human genes 0.000 title 2
108090001061 Insulin Proteins 0.000 title 2
229940125396 insulin Drugs 0.000 title 2
238000000034 method Methods 0.000 title 2
239000002243 precursor Substances 0.000 title 2
101000976075 Homo sapiens Insulin Proteins 0.000 title 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)

AT85303775T 1984-05-30 1985-05-29 INSULIN PRECURSORS, PROCEDURES FOR THEIR PREPARATION AND PROCESSES FOR THE PREPARATION OF HUMAN INSULIN FROM SUCH INSULIN PRECURSORS. ATE66490T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK266584A DK266584D0 (en)	1984-05-30	1984-05-30	DNA SEQUENCE CODING A BIOSYNTHETIC INSULIN PRECURSOR AND PROCEDURE FOR MANUFACTURING THE INSULIN PRECURSOR
DK58285A DK58285D0 (en)	1984-05-30	1985-02-08	PEPTIDES AND MANUFACTURING AND USING THEREOF
EP85303775A EP0163529B1 (en)	1984-05-30	1985-05-29	Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors

Publications (1)

Publication Number	Publication Date
ATE66490T1 true ATE66490T1 (en)	1991-09-15

Family

ID=27220796

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85303775T ATE66490T1 (en)	1984-05-30	1985-05-29	INSULIN PRECURSORS, PROCEDURES FOR THEIR PREPARATION AND PROCESSES FOR THE PREPARATION OF HUMAN INSULIN FROM SUCH INSULIN PRECURSORS.

Country Status (1)

Country	Link
AT (1)	ATE66490T1 (en)

1985
- 1985-05-29 AT AT85303775T patent/ATE66490T1/en not_active IP Right Cessation

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Legal Events

Date	Code	Title	Description
2004-02-15	REN	Ceased due to non-payment of the annual fee