ATE67194T1 - THIADIAZOLYLACETAMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE. - Google Patents

THIADIAZOLYLACETAMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE.

Info

Publication number
ATE67194T1
ATE67194T1 AT87108124T AT87108124T ATE67194T1 AT E67194 T1 ATE67194 T1 AT E67194T1 AT 87108124 T AT87108124 T AT 87108124T AT 87108124 T AT87108124 T AT 87108124T AT E67194 T1 ATE67194 T1 AT E67194T1
Authority
AT
Austria
Prior art keywords
thiadiazolylacetamide
derivatives
processes
production
chem
Prior art date
Application number
AT87108124T
Other languages
German (de)
Inventor
Takeo Kanai
Keizo Takayanagi
Yasuhide Tanaka
Atsushi Koiwa
Shinichi Endoh
Katsuhiko Satoh
Seiichiro Nomoto
Isao Sugiyama
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE67194T1 publication Critical patent/ATE67194T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel thiadiazolylacetamide derivative represented by the following formula (I): <CHEM> wherein R1 means a lower alkyl group and R2 denotes an amino group which may optionally be blocked by a protecting group, or a salt thereof, is prepared by hydrolyzing a compound represented by the following formula (II): <CHEM> wherein R1 and R2 have the same meaning as defined above, or a salt thereof in the presence of an oxidizing agent and a base, then removing the protecting group, if necessary. The thiadiazolylacetamide derivative is useful as an intermediate for the preparation of antibiotics.
AT87108124T 1986-06-05 1987-06-04 THIADIAZOLYLACETAMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE. ATE67194T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61129233A JPH0717622B2 (en) 1986-06-05 1986-06-05 Thiadiazolylacetamide derivative
EP87108124A EP0248434B1 (en) 1986-06-05 1987-06-04 Thiadiazolylacetamide derivatives, process for the preparation thereof and their use

Publications (1)

Publication Number Publication Date
ATE67194T1 true ATE67194T1 (en) 1991-09-15

Family

ID=15004462

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87108124T ATE67194T1 (en) 1986-06-05 1987-06-04 THIADIAZOLYLACETAMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE.

Country Status (6)

Country Link
EP (1) EP0248434B1 (en)
JP (1) JPH0717622B2 (en)
AT (1) ATE67194T1 (en)
DE (1) DE3772852D1 (en)
ES (1) ES2040223T3 (en)
GR (1) GR3002688T3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03130273A (en) * 1989-07-19 1991-06-04 Fujisawa Pharmaceut Co Ltd Production of 2-substituted hydroxyimino-2-(5-amino-1,2,4-thiadiadzol-3-yl)acetic acid or its salt and intermediate thereof
CN105330612B (en) * 2015-11-04 2018-04-03 上海泰坦科技股份有限公司 The synthesis technique of 2 (base of 5 amino, 1,2,4 thiadiazoles 3) 2 methoxyimino acetic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2094794B (en) * 1981-03-06 1985-02-20 Fujisawa Pharmaceutical Co Processes for preparing 2-substituted hydroxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid or its salt and intermediates thereof
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins

Also Published As

Publication number Publication date
JPS62294672A (en) 1987-12-22
ES2040223T3 (en) 1993-10-16
EP0248434A1 (en) 1987-12-09
GR3002688T3 (en) 1993-01-25
JPH0717622B2 (en) 1995-03-01
DE3772852D1 (en) 1991-10-17
EP0248434B1 (en) 1991-09-11

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