ATE67211T1 - C17-20-lyase-inhibitoren. - Google Patents

C17-20-lyase-inhibitoren.

Info

Publication number: ATE67211T1
Authority: AT; Austria
Prior art keywords: compounds; lyase inhibitors; beta; androst; cyclopropylamino
Prior art date: 1987-04-22

Application number

AT88106397T

Other languages

English (en)

Inventor

Michael R Angelastro

Thomas R Blohm

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-22

Filing date

1988-04-21

Publication date

1991-09-15

1988-04-21 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-09-15 Application granted granted Critical

1991-09-15 Publication of ATE67211T1 publication Critical patent/ATE67211T1/de

Links

239000002697 lyase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 abstract 1
LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
150000002081 enamines Chemical class 0.000 abstract 1
150000004678 hydrides Chemical class 0.000 abstract 1
150000002466 imines Chemical class 0.000 abstract 1
230000003637 steroidlike Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Detergent Compositions (AREA)

AT88106397T 1987-04-22 1988-04-21 C17-20-lyase-inhibitoren. ATE67211T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4117287A	1987-04-22	1987-04-22
EP88106397A EP0288053B1 (de)	1987-04-22	1988-04-21	C17-20-Lyase-Inhibitoren

Publications (1)

Publication Number	Publication Date
ATE67211T1 true ATE67211T1 (de)	1991-09-15

Family

ID=21915133

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88106397T ATE67211T1 (de)	1987-04-22	1988-04-21	C17-20-lyase-inhibitoren.

Country Status (19)

Country	Link
EP (1)	EP0288053B1 (de)
JP (1)	JP2711672B2 (de)
KR (1)	KR960015037B1 (de)
CN (1)	CN88102176A (de)
AT (1)	ATE67211T1 (de)
AU (1)	AU606677B2 (de)
CA (1)	CA1326234C (de)
DE (1)	DE3864725D1 (de)
DK (1)	DK217588A (de)
ES (1)	ES2038712T3 (de)
FI (1)	FI88397C (de)
GR (1)	GR3002713T3 (de)
HU (1)	HU198511B (de)
IL (1)	IL86139A (de)
NO (1)	NO169346C (de)
NZ (1)	NZ224288A (de)
PH (1)	PH24090A (de)
PT (1)	PT87294B (de)
ZA (1)	ZA882717B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4891367A (en) *	1987-04-22	1990-01-02	Merrell Dow Pharmaceuticals Inc.	17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US4954488A (en) *	1989-06-14	1990-09-04	Merrell Dow Pharmaceuticals Inc.	Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives
US4966898A (en) *	1989-08-15	1990-10-30	Merrell Dow Pharmaceuticals Inc.	4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5252319A (en) *	1990-06-12	1993-10-12	Insite Vision Incorporated	Aminosteroids for ophthalmic use
US5256408A (en) *	1990-06-12	1993-10-26	Insite Vision Incorporated	Aminosteroids for ophthalmic use
US5124154A (en) *	1990-06-12	1992-06-23	Insite Vision Incorporated	Aminosteroids for ophthalmic use
US5209926A (en) *	1990-06-12	1993-05-11	Insite Vision Incorporated	Aminosteroids for ophthalmic use
ES2138618T3 (es) *	1992-03-31	2000-01-16	Btg Int Ltd	Esteroides 17-sustituidos utiles en el tratamiento del cancer.
US5604213A (en) *	1992-03-31	1997-02-18	British Technology Group Limited	17-substituted steroids useful in cancer treatment
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
CA2429133C (en)	2000-11-17	2009-08-18	Takeda Chemical Industries, Ltd.	Novel imidazole derivatives, production method thereof and use thereof
DE60144246D1 (de)	2000-11-20	2011-04-28	Takeda Pharmaceutical	Imidazolderivate, verfahren zu deren herstellung und deren verwendung
WO2002046186A1 (en)	2000-12-08	2002-06-13	Takeda Chemical Industries, Ltd.	Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
PE20121048A1 (es)	2009-06-26	2012-08-25	Novartis Ag	Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17
KR101594660B1 (ko)	2010-08-04	2016-02-16	펠피큐어 파마슈티걸즈 아이엔씨	전립선 암종의 치료를 위한 병용 요법
EP2627648A1 (de)	2010-09-16	2013-08-21	Novartis AG	17a-HYDROXYLASE-C17, 20-LYASE-INHIBITOREN
MX359399B (es)	2011-04-28	2018-09-27	Novartis Ag	Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
AU2014241816B9 (en)	2013-03-14	2019-02-14	Pellficure Pharmaceuticals Inc.	Novel therapy for prostate carcinoma
WO2016040896A1 (en)	2014-09-12	2016-03-17	Pellficure Pharmaceuticals, Inc.	Compositions and methods for treatment of prostate carcinoma
WO2018080933A1 (en)	2016-10-24	2018-05-03	Pellficure Pharmaceuticals Inc.	Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL302932A (de) *	1962-12-31
US4891367A (en) *	1987-04-22	1990-01-02	Merrell Dow Pharmaceuticals Inc.	17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

1988
- 1988-04-18 ZA ZA882717A patent/ZA882717B/xx unknown
- 1988-04-18 NZ NZ224288A patent/NZ224288A/xx unknown
- 1988-04-18 AU AU14719/88A patent/AU606677B2/en not_active Ceased
- 1988-04-18 CA CA000564364A patent/CA1326234C/en not_active Expired - Fee Related
- 1988-04-19 PH PH36817A patent/PH24090A/en unknown
- 1988-04-20 IL IL86139A patent/IL86139A/xx unknown
- 1988-04-21 FI FI881877A patent/FI88397C/fi not_active IP Right Cessation
- 1988-04-21 ES ES198888106397T patent/ES2038712T3/es not_active Expired - Lifetime
- 1988-04-21 JP JP63096969A patent/JP2711672B2/ja not_active Expired - Fee Related
- 1988-04-21 DK DK217588A patent/DK217588A/da not_active Application Discontinuation
- 1988-04-21 KR KR1019880004512A patent/KR960015037B1/ko not_active Expired - Fee Related
- 1988-04-21 DE DE8888106397T patent/DE3864725D1/de not_active Expired - Fee Related
- 1988-04-21 AT AT88106397T patent/ATE67211T1/de not_active IP Right Cessation
- 1988-04-21 HU HU882029A patent/HU198511B/hu not_active IP Right Cessation
- 1988-04-21 NO NO881746A patent/NO169346C/no unknown
- 1988-04-21 CN CN198888102176A patent/CN88102176A/zh active Pending
- 1988-04-21 EP EP88106397A patent/EP0288053B1/de not_active Expired - Lifetime
- 1988-04-21 PT PT87294A patent/PT87294B/pt not_active IP Right Cessation
1991
- 1991-09-12 GR GR91401315T patent/GR3002713T3/el unknown

Also Published As

Publication number	Publication date
IL86139A0 (en)	1988-11-15
NO169346C (no)	1992-06-10
KR880012633A (ko)	1988-11-28
NO881746D0 (no)	1988-04-21
EP0288053B1 (de)	1991-09-11
FI88397B (fi)	1993-01-29
CA1326234C (en)	1994-01-18
FI881877A7 (fi)	1988-10-23
ES2038712T3 (es)	1993-08-01
PT87294A (pt)	1988-05-01
AU606677B2 (en)	1991-02-14
HUT47307A (en)	1989-02-28
JPS63284195A (ja)	1988-11-21
FI88397C (fi)	1993-05-10
FI881877A0 (fi)	1988-04-21
DK217588D0 (da)	1988-04-21
EP0288053A1 (de)	1988-10-26
AU1471988A (en)	1988-10-27
HU198511B (en)	1989-10-30
PT87294B (pt)	1992-08-31
NO169346B (no)	1992-03-02
NO881746L (no)	1988-10-24
DK217588A (da)	1988-10-23
KR960015037B1 (ko)	1996-10-24
ZA882717B (en)	1988-10-17
NZ224288A (en)	1989-12-21
PH24090A (en)	1990-03-05
JP2711672B2 (ja)	1998-02-10
CN88102176A (zh)	1988-11-23
GR3002713T3 (en)	1993-01-25
IL86139A (en)	1993-02-21
DE3864725D1 (de)	1991-10-17

Legal Events

Date	Code	Title	Description
1992-06-15	UEP	Publication of translation of european patent specification
1995-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3864725D1 (de)	1991-10-17	C17-20-lyase-inhibitoren.
AU628209B2 (en)	1992-09-10	4-substituted 17beta-(cyclopropylamino)androst-5-en-3beta-ol and related compounds useful as c17-20 lyase inhibitors
GB9514451D0 (en)	1995-09-13	Sustained-release formulation
MY106280A (en)	1995-04-29	Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use.
EP0413269A3 (en)	1992-05-20	4-substituted 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol and related compounds useful as c17-20 lyase inhibitors
PH23863A (en)	1989-11-23	17b-(cyclopropyloxy)androst-5-en-3b-ol and related compounds useful as c17-20 lyase inhibitors
ATE222491T1 (de)	2002-09-15	Melatonin-derivate zur verwendung in der behandlung von schlafstörungen
ES2009689A6 (es)	1989-10-01	Procedimiento para preparar derivados de 3-piperidina-carbaldehido-oxima.