ATE6776T1 - Nonapeptide und decapeptide, agonisten des ''lh- rh''-faktors, welche heterocyclische aminosaeurereste enthalten, verfahren zu deren herstellung, deren pharmazeutische zusammensetzungen und deren pharmazeutische verwendung. - Google Patents

Nonapeptide und decapeptide, agonisten des ''lh- rh''-faktors, welche heterocyclische aminosaeurereste enthalten, verfahren zu deren herstellung, deren pharmazeutische zusammensetzungen und deren pharmazeutische verwendung.

Info

Publication number: ATE6776T1
Authority: AT; Austria
Prior art keywords: image; lower alkyl; amino acid; nonapeptides; decapeptides
Prior art date: 1980-06-23

Application number

AT81302806T

Other languages

English (en)

Inventor

John Jones Nestor

Gordon Henry Jones

Brian Henry Vickery

Original Assignee

Syntex (U.S.A.) Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-23

Filing date

1981-06-22

Publication date

1984-04-15

1981-06-22 Application filed by Syntex (U.S.A.) Inc. filed Critical Syntex (U.S.A.) Inc.

1984-04-15 Application granted granted Critical

1984-04-15 Publication of ATE6776T1 publication Critical patent/ATE6776T1/de

Links

101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 title abstract 3
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title abstract 3
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 3
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 3
239000000556 agonist Substances 0.000 title abstract 2
150000001413 amino acids Chemical group 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
125000000405 phenylalanyl group Chemical group 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
150000008574 D-amino acids Chemical group 0.000 abstract 1
-1 N-methyl-leucyl Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 1
125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Endocrinology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT81302806T 1980-06-23 1981-06-22 Nonapeptide und decapeptide, agonisten des ''lh- rh''-faktors, welche heterocyclische aminosaeurereste enthalten, verfahren zu deren herstellung, deren pharmazeutische zusammensetzungen und deren pharmazeutische verwendung. ATE6776T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/162,455 US4318905A (en)	1980-06-23	1980-06-23	Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues
EP81302806A EP0042753B1 (de)	1980-06-23	1981-06-22	Nonapeptide und Decapeptide, Agonisten des "LH-RH"-Faktors, welche heterocyclische Aminosäurereste enthalten, Verfahren zu deren Herstellung, deren pharmazeutische Zusammensetzungen und deren pharmazeutische Verwendung

Publications (1)

Publication Number	Publication Date
ATE6776T1 true ATE6776T1 (de)	1984-04-15

Family

ID=22585695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT81302806T ATE6776T1 (de)	1980-06-23	1981-06-22	Nonapeptide und decapeptide, agonisten des ''lh- rh''-faktors, welche heterocyclische aminosaeurereste enthalten, verfahren zu deren herstellung, deren pharmazeutische zusammensetzungen und deren pharmazeutische verwendung.

Country Status (8)

Country	Link
US (1)	US4318905A (de)
EP (1)	EP0042753B1 (de)
AT (1)	ATE6776T1 (de)
AU (1)	AU538188B2 (de)
DE (1)	DE3162788D1 (de)
IE (1)	IE51311B1 (de)
NZ (1)	NZ197499A (de)
ZA (1)	ZA814214B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4419347A (en) *	1980-10-06	1983-12-06	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4675189A (en) *	1980-11-18	1987-06-23	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble active polypeptides
HU185535B (en) *	1982-05-25	1985-02-28	Mta Koezponti Hivatala	Process for preparing new gonadoliberin derivatives
US4530920A (en) *	1983-11-07	1985-07-23	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4762717A (en) *	1986-03-21	1988-08-09	The General Hospital Corporation	Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive
US4761398A (en) *	1986-08-18	1988-08-02	Embrex, Inc.	Method of inducing birds to molt
US4897268A (en) *	1987-08-03	1990-01-30	Southern Research Institute	Drug delivery system and method of making the same
DE4119856A1 (de) *	1991-06-17	1992-12-24	Hoechst Ag	N-acyl-s-(2-hydroxyalkyl)-cysteine, deren herstellung sowie deren verwendung als zwischenprodukte zur herstellung von synthetischen immunadjuvantien und synthetischen impfstoffen
US5518730A (en)	1992-06-03	1996-05-21	Fuisz Technologies Ltd.	Biodegradable controlled release flash flow melt-spun delivery system
ES2051647B1 (es) *	1992-12-10	1995-01-16	Lipotec Sa	Procedimiento para la preparacion de calcitonina de salmon.
US6316585B1 (en) *	1999-01-18	2001-11-13	Council Of Scientific And Industrial Research	Process for the preparation of enzymatically degradable polymers
US20050063937A1 (en) *	2003-09-16	2005-03-24	Cheng Li	Multiple-arm peptide compounds, methods of manufacture and use in therapy
US9763977B2 (en)	2003-09-16	2017-09-19	Incube Labs, Llc	In vitro bio-reactor circuit
DE102008033205B4 (de) *	2008-07-15	2024-06-27	Zf Automotive Germany Gmbh	Bauelementhalter zur Befestigung eines elektronischen Bauelements
CN105132395A (zh)	2009-03-09	2015-12-09	生物蛋白有限公司	Mirac蛋白
WO2015175375A1 (en)	2014-05-13	2015-11-19	Short Jay M	Conditionally active biological proteins
KR20170044115A (ko)	2014-09-03	2017-04-24	바이오아트라, 엘엘씨	동일한 진핵생물 세포 생산 숙주 내 조건부 활성 생체 단백질의 발견 및 제조
AU2016222830B2 (en)	2015-02-24	2021-02-25	Bioatla Llc	Conditionally active biological proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3842065A (en) *	1973-02-22	1974-10-15	American Home Prod	Homo-(tyr5')-lrf and thr4-lrf and intermediates
JPS5726506B2 (de) *	1974-03-08	1982-06-04
DK568274A (de) *	1973-11-01	1975-06-23	Wellcome Found
GB1532211A (en) *	1974-10-25	1978-11-15	Wellcome Found	Lh-rh peptide analogues
US4034082A (en) *	1976-03-01	1977-07-05	Abbott Laboratories	Method to prevent reproduction in warm-blooded female animals with nonapeptides
US4089946A (en) *	1976-06-07	1978-05-16	American Home Products Corporation	Claudogenic-interceptive nonapeptides
IT1149971B (it) *	1979-06-11	1986-12-10	Syntex Inc	Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante

1980
- 1980-06-23 US US06/162,455 patent/US4318905A/en not_active Expired - Lifetime
1981
- 1981-06-22 AT AT81302806T patent/ATE6776T1/de not_active IP Right Cessation
- 1981-06-22 DE DE8181302806T patent/DE3162788D1/de not_active Expired
- 1981-06-22 ZA ZA814214A patent/ZA814214B/xx unknown
- 1981-06-22 IE IE1378/81A patent/IE51311B1/en unknown
- 1981-06-22 EP EP81302806A patent/EP0042753B1/de not_active Expired
- 1981-06-22 AU AU72018/81A patent/AU538188B2/en not_active Ceased
- 1981-06-22 NZ NZ197499A patent/NZ197499A/en unknown

Also Published As

Publication number	Publication date
IE811378L (en)	1981-12-23
EP0042753A1 (de)	1981-12-30
AU538188B2 (en)	1984-08-02
DE3162788D1 (en)	1984-04-26
NZ197499A (en)	1985-08-16
ZA814214B (en)	1983-02-23
AU7201881A (en)	1982-01-07
US4318905A (en)	1982-03-09
EP0042753B1 (de)	1984-03-21
IE51311B1 (en)	1986-11-26

Legal Events

Date	Code	Title	Description
1984-09-15	UEP	Publication of translation of european patent specification
1989-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE6776T1 (de)	1984-04-15	Nonapeptide und decapeptide, agonisten des ''lh- rh''-faktors, welche heterocyclische aminosaeurereste enthalten, verfahren zu deren herstellung, deren pharmazeutische zusammensetzungen und deren pharmazeutische verwendung.
NZ210121A (en)	1989-03-29	Nonapeptides and decapeptide analogues of lhrh and pharmaceutical compositions
LU88272I2 (de)	1994-02-03
FI960155A7 (fi)	1996-01-12	Terapeuttisia heterosyklisiä yhdisteitä
ATE14128T1 (de)	1985-07-15	Nonapeptid- und decapeptid-analoge von lhrh, nuetzlich als lhrh-antagonisten, methoden zu deren herstellung und deren pharmazeutische anwendung.
IE801193L (en)	1980-12-11	Nonapeptide and decapeptide derivatives of lutenizing¹hormone releasing hormone
NZ241169A (en)	1995-01-27	Substituted azole derivatives, preparatory processes and pharmaceutical compositions
HUT64566A (en)	1994-01-28	Method for producing antagonists of nonapeptide bombesine
AU633408B2 (en)	1993-01-28	New imidazo (1,2-c) derivatives, process for the preparation thereof and pharmaceutical compositions containing them
DK486089A (da)	1989-12-01	Pyranobenzoxadiazolderivater
ATE70278T1 (de)	1991-12-15	Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und und ihre verwendung.
IL90560A0 (en)	1990-01-18	Phenothiazine derivatives,method for their preparation and pharmaceutical compositions containing them
ZA899321B (en)	1990-08-29	Indole derivatives,process for preparing them and pharmaceutical compositions containing them
DE69008956D1 (de)	1994-06-23	Arylsulphonylnitromethane, verfahren zu deren herstellung und pharmazeutische zusammensetzungen.