ATE68349T1 - Medizinische verwendung von nukleosiden. - Google Patents

Medizinische verwendung von nukleosiden.

Info

Publication number: ATE68349T1
Authority: AT; Austria
Prior art keywords: nucleosides; medical use; treatment; infections; formulawherein
Prior art date: 1986-07-04

Application number

AT87904641T

Other languages

English (en)

Inventor

Bertil Frank Harald Eriksson

Karl Nils Gunnar Johansson

Goeran Bertil Stening

Bo Fredrik Oeberg

Original Assignee

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-04

Filing date

1987-07-02

Publication date

1991-11-15

1987-07-02 Application filed by Medivir Ab filed Critical Medivir Ab

1991-11-15 Application granted granted Critical

1991-11-15 Publication of ATE68349T1 publication Critical patent/ATE68349T1/de

Links

239000002777 nucleoside Substances 0.000 title 1
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940104302 cytosine Drugs 0.000 abstract 1
208000002672 hepatitis B Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229940113082 thymine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Oncology (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Materials For Medical Uses (AREA)

AT87904641T 1986-07-04 1987-07-02 Medizinische verwendung von nukleosiden. ATE68349T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE8602981A SE8602981D0 (sv)	1986-07-04	1986-07-04	Novel medicinal use
EP87904641A EP0277151B1 (de)	1986-07-04	1987-07-02	Medizinische verwendung von nukleosiden
PCT/SE1987/000316 WO1988000050A1 (en)	1986-07-04	1987-07-02	Novel medicinal use of nucleosides

Publications (1)

Publication Number	Publication Date
ATE68349T1 true ATE68349T1 (de)	1991-11-15

Family

ID=20365027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87904641T ATE68349T1 (de)	1986-07-04	1987-07-02	Medizinische verwendung von nukleosiden.

Country Status (10)

Country	Link
US (1)	US6358934B1 (de)
EP (1)	EP0277151B1 (de)
JP (1)	JP2540576B2 (de)
AT (1)	ATE68349T1 (de)
AU (1)	AU598575B2 (de)
CA (1)	CA1286991C (de)
DE (1)	DE3773892D1 (de)
DK (1)	DK172617B1 (de)
SE (1)	SE8602981D0 (de)
WO (1)	WO1988000050A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
SE9800452D0 (sv) *	1998-02-13	1998-02-13	Medivir Ab	Antivirals
GB8719877D0 (en) *	1987-08-22	1987-09-30	Wellcome Found	Antiviral compounds
US5506215A (en) *	1987-11-03	1996-04-09	Medivir Ab	1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides
GB8726136D0 (en) *	1987-11-07	1987-12-09	Wellcome Found	Therapeutic nucleosides
SE8802687D0 (sv) *	1988-07-20	1988-07-20	Astra Ab	Nucleoside derivatives
US5157114A (en) *	1988-08-19	1992-10-20	Burroughs Wellcome Co.	2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8904855D0 (en) *	1989-03-03	1989-04-12	Beecham Group Plc	Pharmaceutical treatment
SE464168B (sv) *	1989-07-19	1991-03-18	Bo Fredrik Oeberg	Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
DD293498A5 (de) *	1989-07-20	1991-09-05	Zi Fuer Molekularbiologie Der Adw,De	Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB9003543D0 (en) *	1990-02-16	1990-04-11	Wellcome Found	Therapeutic nucleosides
GB9200150D0 (en) *	1992-01-06	1992-02-26	Wellcome Found	Therapeutic nucleosides
ATE178335T1 (de) *	1992-01-06	1999-04-15	Wellcome Found	Therapeutische nukleoside der 2',3'-dideoxy-3'- fluor -purin reihe
US5334525A (en) *	1992-08-28	1994-08-02	Fox Chase Cancer Center	Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
US5360714A (en) *	1992-08-28	1994-11-01	Fox Chase Cancer Center	Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
US5627160A (en) *	1993-05-25	1997-05-06	Yale University	L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) *	1993-05-25	1999-11-11	Univ Yale	L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
EP0788507B1 (de) *	1994-10-24	2004-12-15	Genencor International, Inc.	L-pyranosyl-nukleoside
US5559101A (en) *	1994-10-24	1996-09-24	Genencor International, Inc.	L-ribofuranosyl nucleosides
US5869461A (en) *	1995-03-16	1999-02-09	Yale University	Reducing toxicity of L-nucleosides with D-nucleosides
SI0988304T1 (en) *	1997-08-15	2001-08-31	Medivir Ab	Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
US20060084627A1 (en) *	2002-06-27	2006-04-20	Medivir Ab	Synergistic interaction of abacavir and alovudine
EP1610782A1 (de) *	2003-03-27	2006-01-04	Boehringer Ingelheim International GmbH	Antivirale kombination eines dipyridodiazepinons und einer weiteren antiretroviralen verbindung
EP1610797A1 (de) *	2003-03-27	2006-01-04	Boehringer Ingelheim International GmbH	Antivirale kombination von nevirapin und einer weiteren antiretroviralen verbindung
EP1610781A1 (de) *	2003-03-27	2006-01-04	Boehringer Ingelheim International GmbH	Antivirale kombination von tipranavir und einer weiteren antiretroviralen verbindung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3775397A (en) *	1969-11-12	1973-11-27	Akad Wissenschaften Ddr	Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
DD139793A1 (de) *	1978-11-06	1980-01-23	Waltraud Braun	Mittel gegen psoriasis
DD158903A1 (de) *	1981-05-18	1983-02-09	Gotthard Kowollik	Verfahren zur herstellung von 3'-fluor-2',3'-didesoxyadenosin
DD209197A1 (de) *	1981-07-21	1984-04-25	Akad Wissenschaften Ddr	Verfahren zur herstellung von 3'-fluor-2',3'-didesoxyguanosin
US4724232A (en)	1985-03-16	1988-02-09	Burroughs Wellcome Co.	Treatment of human viral infections
NZ216172A (en) *	1985-05-15	1989-08-29	Wellcome Found	Nucleosides and pharmaceutical compositions
EP0258412A1 (de)	1986-02-20	1988-03-09	GREER, Sheldon B.	Zubereitung und verfahren zur behandlung von aids und verwandten krankheiten

1986
- 1986-07-04 SE SE8602981A patent/SE8602981D0/xx unknown
1987
- 1987-07-02 WO PCT/SE1987/000316 patent/WO1988000050A1/en not_active Ceased
- 1987-07-02 EP EP87904641A patent/EP0277151B1/de not_active Expired - Lifetime
- 1987-07-02 AT AT87904641T patent/ATE68349T1/de not_active IP Right Cessation
- 1987-07-02 JP JP62504153A patent/JP2540576B2/ja not_active Expired - Lifetime
- 1987-07-02 AU AU77005/87A patent/AU598575B2/en not_active Expired
- 1987-07-02 DE DE8787904641T patent/DE3773892D1/de not_active Expired - Lifetime
- 1987-07-03 CA CA000541194A patent/CA1286991C/en not_active Expired - Lifetime
1988
- 1988-02-23 DK DK198800927A patent/DK172617B1/da not_active IP Right Cessation
1989
- 1989-03-07 US US07/319,840 patent/US6358934B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3773892D1 (de)	1991-11-21
EP0277151B1 (de)	1991-10-16
US6358934B1 (en)	2002-03-19
JPH01500193A (ja)	1989-01-26
CA1286991C (en)	1991-07-30
SE8602981D0 (sv)	1986-07-04
EP0277151A1 (de)	1988-08-10
DK92788A (da)	1988-02-23
AU598575B2 (en)	1990-06-28
DK92788D0 (da)	1988-02-23
DK172617B1 (da)	1999-03-01
JP2540576B2 (ja)	1996-10-02
WO1988000050A1 (en)	1988-01-14
AU7700587A (en)	1988-01-29

Legal Events

Date	Code	Title	Description
1992-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE68349T1 (de)	1991-11-15	Medizinische verwendung von nukleosiden.
ATE219366T1 (de)	2002-07-15	Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b
TW371660B (en)	1999-10-11	Therapeutic nucleosides a purine carbocyclic nucleosides for treatment of HIV and HBV infections
ATE135363T1 (de)	1996-03-15	Nucleoside zur verwendung für die therapie
ES2131116T3 (es)	1999-07-16	Analogos de nucleotidos enantiomericos antirretrovirales.
ATE54009T1 (de)	1990-07-15	Molekulare klone des genoms von htlv-iii.
DK224286D0 (da)	1986-05-14	2',3'-dideoxy-nucleosider
NO167576C (no)	1991-11-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-substituerte pyrimidinnukleosider.
SE8900192D0 (sv)	1989-01-19	Dideoxididehydrokarbocykliska nukleosider
EP0494231A4 (en)	1992-09-16	6-amino-1,2-benzopyrones useful for treatment of viral diseases
FI875544A7 (fi)	1988-06-18	3'-deoksitymidin-2'-eenin (3'-deoksi-2',3'-didehydrotymidiini) käyttö retroviruksilla infektoituneiden potilaiden hoitoon.
PT777669E (pt)	2002-11-29	Utilizacao de succinato de 4-(2-amino-6-(ciclopropilamino)-9h-purin-9-il)-2-ciclopenteno-1-metanol como agente antiviral
ATE267198T1 (de)	2004-06-15	Synthese und anti-hiv und anti-hepatitis virus aktivität von 1,3-oxaselenolan nucleosiden
DK615788A (da)	1989-05-08	Nucleosidforbindelser til anvendelse mod virale infektioner
DE69324244D1 (de)	1999-05-06	Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
DK707988D0 (da)	1988-12-20	Fremgangsmaade til at haemme virus
MY105855A (en)	1995-02-28	Therapeutic nucleotides.
ATE147746T1 (de)	1997-02-15	Derivate von fluorphosphonat-nukleotiden
EP0286825A3 (de)	1989-04-12	Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
ATE232108T1 (de)	2003-02-15	Interleukin - 8 als antivirale- und antitumorwirkstoffe
EP0316592A3 (de)	1990-09-19	3'-Fluor-2',3'-dideoxyuridin und seine therapeutische Verwendung
ATE26267T1 (de)	1987-04-15	Pyrimidin-derivate, ausgestattet mit antiviraler wirkung.
WO1988003804A3 (en)	1988-10-06	Method of treating viral infections in humans and compositions therefor
ES2006672A6 (es)	1989-05-01	Procedimiento para preparar formulaciones farmaceuticas a base de 3'-azido-nucleosidos.
MY113560A (en)	2002-04-30	Use of 5-fluoro-2'-deoxy-3'-thiacytidine for the treatment of hepatitis b