ATE69234T1 - Ekteinascidine 729, 743, 745, 759a, 759b and 770. - Google Patents

Ekteinascidine 729, 743, 745, 759a, 759b and 770.

Info

Publication number
ATE69234T1
ATE69234T1 AT87904158T AT87904158T ATE69234T1 AT E69234 T1 ATE69234 T1 AT E69234T1 AT 87904158 T AT87904158 T AT 87904158T AT 87904158 T AT87904158 T AT 87904158T AT E69234 T1 ATE69234 T1 AT E69234T1
Authority
AT
Austria
Prior art keywords
ecteinascidine
ecteinascidins
antibacterial
novel compounds
antitumor properties
Prior art date
Application number
AT87904158T
Other languages
English (en)
Inventor
Kenneth L Rinehart
Tom G Holt
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of ATE69234T1 publication Critical patent/ATE69234T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/655—Aquatic animals other than those covered by groups A61K35/57 - A61K35/65
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oceanography (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Valve Device For Special Equipments (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Dental Preparations (AREA)
  • Paper (AREA)
  • Sealing Devices (AREA)
AT87904158T 1986-06-09 1987-06-01 Ekteinascidine 729, 743, 745, 759a, 759b and 770. ATE69234T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87218986A 1986-06-09 1986-06-09
US89890686A 1986-08-21 1986-08-21
US639587A 1987-01-23 1987-01-23
EP87904158A EP0309477B1 (de) 1986-06-09 1987-06-01 Ekteinascidine 729, 743, 745, 759a, 759b und 770
PCT/US1987/001226 WO1987007610A2 (en) 1986-06-09 1987-06-01 Ecteinascidins 729, 743, 745, 759a, 759b and 770

Publications (1)

Publication Number Publication Date
ATE69234T1 true ATE69234T1 (de) 1991-11-15

Family

ID=27358119

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87904158T ATE69234T1 (de) 1986-06-09 1987-06-01 Ekteinascidine 729, 743, 745, 759a, 759b and 770.

Country Status (7)

Country Link
EP (1) EP0309477B1 (de)
JP (1) JP2562162B2 (de)
AT (1) ATE69234T1 (de)
AU (1) AU589282B2 (de)
DE (1) DE3774435D1 (de)
FI (1) FI885726A0 (de)
WO (1) WO1987007610A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316214B1 (en) 1998-05-11 2001-11-13 The Board Of Trustees Of The University Of Illinois ETM-775 metabolite of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
GB9918178D0 (en) * 2000-05-15 1999-10-06 Pharma Mar Sa Synthetic methods
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
BG65893B1 (bg) * 1999-05-14 2010-04-30 Pharma Mar S.A. Полусинтетичен метод и нови съединения
ATE299146T1 (de) 2000-04-12 2005-07-15 Pharma Mar Sa Ecteinaschidin derivate mit antikrebs wirkung
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
KR101188691B1 (ko) * 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
CA2800097C (en) 2010-05-25 2019-01-08 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds and intermediates
CA2995033C (en) 2010-11-12 2020-04-28 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
TWI807411B (zh) 2017-04-27 2023-07-01 西班牙商瑪製藥股份有限公司 抗腫瘤化合物
EP4061372A1 (de) 2019-11-21 2022-09-28 Pharma Mar, S.A. Verfahren zur behandlung von kleinzelligem lungenkrebs mit lurbinectedinformulierungen
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
WO2026022359A2 (en) 2024-07-26 2026-01-29 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770

Also Published As

Publication number Publication date
FI885726L (fi) 1988-12-09
JP2562162B2 (ja) 1996-12-11
EP0309477A1 (de) 1989-04-05
JPH01502749A (ja) 1989-09-21
WO1987007610A2 (en) 1987-12-17
AU589282B2 (en) 1989-10-05
FI885726A7 (fi) 1988-12-09
AU7581987A (en) 1988-01-11
FI885726A0 (fi) 1988-12-09
WO1987007610A3 (en) 1988-02-25
DE3774435D1 (de) 1991-12-12
EP0309477B1 (de) 1991-11-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time