ATE70444T1 - Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen. - Google Patents

Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen.

Info

Publication number: ATE70444T1
Authority: AT; Austria
Prior art keywords: topical; treatment; epithelial diseases; hyperproliferative epithelial; methotrexate
Prior art date: 1986-05-30

Application number

AT87304797T

Other languages

English (en)

Inventor

Gerald D Weinstein

Jerry L Mccullough

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-30

Filing date

1987-05-29

Publication date

1992-01-15

1987-05-29 Application filed by Univ California filed Critical Univ California

1992-01-15 Application granted granted Critical

1992-01-15 Publication of ATE70444T1 publication Critical patent/ATE70444T1/de

Links

230000000699 topical effect Effects 0.000 title abstract 3
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title abstract 2
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
230000003463 hyperproliferative effect Effects 0.000 title abstract 2
229960000485 methotrexate Drugs 0.000 title abstract 2
201000004681 Psoriasis Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000035515 penetration Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT87304797T 1986-05-30 1987-05-29 Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen. ATE70444T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86893686A	1986-05-30	1986-05-30
EP87304797A EP0247900B1 (de)	1986-05-30	1987-05-29	Topische Methotrexatzubereitung zur Behandlung hyperproliferativer Epithelerkrankungen

Publications (1)

Publication Number	Publication Date
ATE70444T1 true ATE70444T1 (de)	1992-01-15

Family

ID=25352598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87304797T ATE70444T1 (de)	1986-05-30	1987-05-29	Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen.

Country Status (9)

Country	Link
EP (1)	EP0247900B1 (de)
JP (1)	JPS6327432A (de)
AT (1)	ATE70444T1 (de)
CA (1)	CA1300508C (de)
DE (1)	DE3775278D1 (de)
DK (1)	DK277387A (de)
ES (1)	ES2038663T3 (de)
NZ (1)	NZ220495A (de)
ZA (1)	ZA873928B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2808492A (en) *	1991-10-26	1993-05-21	East Riding Laboratories Limited	Medicament composition for topical application
AU5495798A (en) *	1997-01-16	1998-08-07	Sekisui Chemical Co., Ltd.	External preparations for percutaneous absorption
KR100439204B1 (ko) *	2000-10-25	2004-07-07	주식회사 삼양사	메토트렉세이트를 유효성분으로 함유하는 경피투여용 조성물
BR102012009350B1 (pt) *	2012-04-20	2020-12-29	Biolab Sanus Farmacêutica Ltda	composição farmacêutica tópica, processo de produção da composição farmacêutica tópica e uso da composição farmacêutica tópica
US20210186862A1 (en) *	2017-12-05	2021-06-24	Shilpa Medicare Ltd	Methotrexate topical solution for treatment of psoriasis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1553310A (en) *	1975-06-19	1979-09-26	Nelson Res & Dev	Vehicle composition containing 1-substituted azacycloalkan-2-ones
GB2143433A (en) *	1983-06-20	1985-02-13	Hariprasad Manibhai Patel	Methotrexate ointment
US4557934A (en) *	1983-06-21	1985-12-10	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4743588A (en) *	1984-06-13	1988-05-10	Allergan Pharmaceuticals, Inc.	Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents

1987
- 1987-05-29 AT AT87304797T patent/ATE70444T1/de not_active IP Right Cessation
- 1987-05-29 DK DK277387A patent/DK277387A/da not_active Application Discontinuation
- 1987-05-29 DE DE8787304797T patent/DE3775278D1/de not_active Expired - Lifetime
- 1987-05-29 NZ NZ220495A patent/NZ220495A/xx unknown
- 1987-05-29 JP JP62137609A patent/JPS6327432A/ja active Pending
- 1987-05-29 EP EP87304797A patent/EP0247900B1/de not_active Expired - Lifetime
- 1987-05-29 ES ES198787304797T patent/ES2038663T3/es not_active Expired - Lifetime
- 1987-06-01 CA CA000538541A patent/CA1300508C/en not_active Expired - Lifetime
- 1987-06-02 ZA ZA873928A patent/ZA873928B/xx unknown

Also Published As

Publication number	Publication date
ES2038663T3 (es)	1993-08-01
DK277387A (da)	1987-12-01
ZA873928B (en)	1988-02-24
EP0247900B1 (de)	1991-12-18
JPS6327432A (ja)	1988-02-05
DK277387D0 (da)	1987-05-29
NZ220495A (en)	1990-07-26
EP0247900A1 (de)	1987-12-02
CA1300508C (en)	1992-05-12
DE3775278D1 (de)	1992-01-30

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Legal Events

Date	Code	Title	Description
1992-08-15	UEP	Publication of translation of european patent specification
1996-02-15	REN	Ceased due to non-payment of the annual fee