ATE71629T1 - Methylenphosphonalkylphosphinate, pharmazeutische zubereitungen und verfahren zur behandlung abnormalen kalzium- und phosphat-stoffwechsels. - Google Patents
Methylenphosphonalkylphosphinate, pharmazeutische zubereitungen und verfahren zur behandlung abnormalen kalzium- und phosphat-stoffwechsels.Info
- Publication number
- ATE71629T1 ATE71629T1 AT88201384T AT88201384T ATE71629T1 AT E71629 T1 ATE71629 T1 AT E71629T1 AT 88201384 T AT88201384 T AT 88201384T AT 88201384 T AT88201384 T AT 88201384T AT E71629 T1 ATE71629 T1 AT E71629T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- methylenephosphonelkylphosphinates
- treatment
- phosphate metabolism
- abnormal calcium
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 230000002159 abnormal effect Effects 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 230000004060 metabolic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6966687A | 1987-07-06 | 1987-07-06 | |
| EP88201384A EP0298553B1 (de) | 1987-07-06 | 1988-07-04 | Methylenphosphonalkylphosphinate, pharmazeutische Zubereitungen und Verfahren zur Behandlung abnormalen Kalzium- und Phosphat-Stoffwechsels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE71629T1 true ATE71629T1 (de) | 1992-02-15 |
Family
ID=22090458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88201384T ATE71629T1 (de) | 1987-07-06 | 1988-07-04 | Methylenphosphonalkylphosphinate, pharmazeutische zubereitungen und verfahren zur behandlung abnormalen kalzium- und phosphat-stoffwechsels. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5574024A (de) |
| EP (1) | EP0298553B1 (de) |
| JP (1) | JP2859271B2 (de) |
| KR (1) | KR0126768B1 (de) |
| AT (1) | ATE71629T1 (de) |
| AU (1) | AU608335B2 (de) |
| DE (1) | DE3867736D1 (de) |
| DK (1) | DK375588A (de) |
| IE (1) | IE60914B1 (de) |
| IL (1) | IL86951A (de) |
| NZ (1) | NZ225274A (de) |
| ZA (1) | ZA884792B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
| US5212164A (en) * | 1988-08-29 | 1993-05-18 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
| CA2018470A1 (en) * | 1989-07-17 | 1991-01-17 | Scott Adams Biller | Phosphorus-containing squalene synthetase inhibitors and method |
| IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
| EP0491374B1 (de) * | 1990-12-19 | 1996-01-31 | Takeda Chemical Industries, Ltd. | Bisphosphonsäurederivate, ihre Produktion und ihre Verwendung |
| CZ282609B6 (cs) | 1991-02-26 | 1997-08-13 | Norwich Eaton Pharmaceuticals, Inc. | Směs v jednotné dávkovací formě pro léčení osteoporozy |
| CA2067974A1 (en) * | 1991-05-13 | 1992-11-14 | Scott A. Biller | Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor |
| EP0522576A3 (en) * | 1991-07-12 | 1993-07-14 | Hoechst Aktiengesellschaft | Aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphospinic/phosphonic acids, process of their preparation and their use |
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| TW222637B (de) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| US5731299A (en) * | 1992-05-29 | 1998-03-24 | The Procter & Gamble Company | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5760021A (en) * | 1992-05-29 | 1998-06-02 | The Procter & Gamble Company | Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| EP0642518B1 (de) * | 1992-05-29 | 1998-08-05 | Procter & Gamble Pharmaceuticals | Phosphono suphonate verbindungen zur behandlung abnormalen kalzium- und phospat- metabolismuses |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| HUT69699A (en) * | 1992-05-29 | 1995-09-28 | Procter & Gamble Pharma | Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism |
| ES2118967T3 (es) * | 1992-05-29 | 1998-10-01 | Procter & Gamble Pharma | Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales. |
| EP0642521A1 (de) * | 1992-05-29 | 1995-03-15 | Procter & Gamble Pharmaceuticals | Thio-substituierte stickstoff-enthaltende heterozyclische phosphonat-verbindungen zur behandlung von abnormalem calzium-und phosphat-metabolismus |
| MY131438A (en) * | 1992-05-29 | 2007-08-30 | Procter & Gamble Pharma | Novel phosphonocarboxylate compounds, pharmaceutical compositions and methods for treating abnormal calcium and phosphate metabolism |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| NZ253631A (en) * | 1992-06-30 | 1997-02-24 | Procter & Gamble Pharma | Phosphonate or nsaid pharmaceutical compositions for treating arthritis |
| ES2111163T3 (es) * | 1992-06-30 | 1998-03-01 | Procter & Gamble Pharma | Uso de fosfonatos para el tratamiento de la osteoporosis. |
| US5254544A (en) * | 1992-09-25 | 1993-10-19 | E. R. Squibb & Sons, Inc. | Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method |
| EP0663919A1 (de) * | 1992-10-09 | 1995-07-26 | PHARMACIA & UPJOHN COMPANY | Pyrimidin bisphosphonsäureestern als anti-inflammatorisches mittel |
| ES2129485T3 (es) * | 1992-12-02 | 1999-06-16 | Hoechst Ag | Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion. |
| DE4437137A1 (de) * | 1994-10-18 | 1996-04-25 | Hoechst Schering Agrevo Gmbh | Substituierte Cycloalkylamino- und -alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| SE9901572D0 (sv) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| DE60307799T2 (de) * | 2002-03-19 | 2007-08-16 | Genzyme Corp., Cambridge | Hemmer des phosphattransports |
| GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
| US11793452B2 (en) | 2019-10-03 | 2023-10-24 | Johnson & Johnson Consumer Inc. | Method of visualizing and quantifying remineralization |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3553314A (en) * | 1968-12-23 | 1971-01-05 | Procter & Gamble | Oral compositions for calculus retardation |
| US3701817A (en) * | 1969-03-28 | 1972-10-31 | Monsanto Co | Halogenated phosphorus compounds containing the atom skeleton p-(c-p)2 or p-(c-p)3 and preparation |
| DE1958123C3 (de) * | 1969-11-19 | 1978-09-28 | Henkel Kgaa, 4000 Duesseldorf | Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen |
| US3979385A (en) * | 1969-11-19 | 1976-09-07 | Henkel & Cie G.M.B.H. | 1-Aminoalkane-1,1-diphosphonic acids and their salts |
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| US3899496A (en) * | 1970-10-06 | 1975-08-12 | Henkel & Cie Gmbh | Production of 1-aminoalkane-1,1-diphosphonic acids |
| DE2104476C2 (de) * | 1971-02-01 | 1983-12-01 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Verhinderung von Ausfällungen in Wasser oder wäßrigen Lösungen |
| US3988443A (en) * | 1973-08-27 | 1976-10-26 | Henkel & Cie G.M.B.H. | Azacycloalkane-2,2-diphosphonic acids |
| DE2343196C3 (de) * | 1973-08-27 | 1980-01-10 | Henkel Kgaa, 4000 Duesseldorf | Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze |
| DE2343147C2 (de) * | 1973-08-27 | 1982-06-09 | Henkel KGaA, 4000 Düsseldorf | Pyrrolidon-5,5-diphosphonsäuren, deren wasserlösliche Salze, und Verfahren zu ihrer Herstellung |
| DE2360798A1 (de) * | 1973-12-06 | 1975-06-26 | Henkel & Cie Gmbh | Pharmazeutische oder kosmetische praeparate |
| JPS5095227A (de) * | 1973-12-26 | 1975-07-29 | ||
| US4134969A (en) * | 1974-02-04 | 1979-01-16 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Method of treatment of calcium disorders using aminoalkane-diphosphonic acids |
| DE2456666A1 (de) * | 1974-11-30 | 1976-08-12 | Henkel & Cie Gmbh | Verfahren zum stabilisieren von calcium-hydrogenphosphat-dihydrat gegen hydrolyse |
| DE2513966C2 (de) * | 1975-03-29 | 1983-06-23 | Henkel KGaA, 4000 Düsseldorf | Piperidon-6,6-diphosphonsäure und Verfahren zu deren Herstellung |
| DE2541981A1 (de) * | 1975-09-20 | 1977-03-24 | Bayer Ag | Verfahren zur herstellung von azacycloalkandiphosphonsaeuren |
| JPS5359674A (en) * | 1976-10-25 | 1978-05-29 | Nissan Chem Ind Ltd | 1-piperidinoalkane-1,1-diphosphonic acid derivatives and herbicidescontaining the same as active agent |
| US4113861A (en) * | 1977-05-02 | 1978-09-12 | The Procter & Gamble Company | Phosphonate pharmaceutical composition |
| DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| JPS54135724A (en) * | 1978-04-11 | 1979-10-22 | Nissan Chem Ind Ltd | Preparation of amino-methylenedisulfonic acid derivative |
| US4138431A (en) * | 1978-06-29 | 1979-02-06 | Nalco Chemical Company | Reaction of α-phosphorus containing carboxylic acids with phosphorous acid to prepare scale and corrosion inhibitors |
| JPS5598193A (en) * | 1979-01-22 | 1980-07-25 | Nissan Chem Ind Ltd | Methylenediphosphonic acid derivative and herbicide comprising it as active constituent |
| IL61985A0 (en) * | 1980-02-01 | 1981-02-27 | Sparamedica Ag | Phosphinic and phosphonic acid derivatives,their manufacture and pharmaceutical compositions containing them |
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| DE3208600A1 (de) * | 1982-03-10 | 1983-09-22 | Henkel KGaA, 4000 Düsseldorf | Amidinodiphosphonsaeuren |
| IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| DE3334211A1 (de) * | 1983-09-22 | 1985-04-04 | Henkel KGaA, 4000 Düsseldorf | Dihydroxyalkandiphosphonsaeuren |
| DE3425812A1 (de) * | 1984-07-13 | 1986-01-16 | Deutsches Krebsforschungszentrum, 6900 Heidelberg | Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4639338A (en) * | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| DE3512536A1 (de) * | 1985-04-06 | 1986-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| GB8530603D0 (en) * | 1985-12-12 | 1986-01-22 | Leo Pharm Prod Ltd | Chemical compounds |
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
-
1988
- 1988-07-01 IL IL8695188A patent/IL86951A/en not_active IP Right Cessation
- 1988-07-04 EP EP88201384A patent/EP0298553B1/de not_active Expired - Lifetime
- 1988-07-04 DE DE8888201384T patent/DE3867736D1/de not_active Expired - Fee Related
- 1988-07-04 AT AT88201384T patent/ATE71629T1/de not_active IP Right Cessation
- 1988-07-04 NZ NZ225274A patent/NZ225274A/xx unknown
- 1988-07-05 IE IE205088A patent/IE60914B1/en not_active IP Right Cessation
- 1988-07-05 ZA ZA884792A patent/ZA884792B/xx unknown
- 1988-07-06 DK DK375588A patent/DK375588A/da not_active Application Discontinuation
- 1988-07-06 KR KR1019880008337A patent/KR0126768B1/ko not_active Expired - Fee Related
- 1988-07-06 AU AU18767/88A patent/AU608335B2/en not_active Ceased
- 1988-07-06 JP JP63168628A patent/JP2859271B2/ja not_active Expired - Lifetime
-
1994
- 1994-06-03 US US08/253,818 patent/US5574024A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU608335B2 (en) | 1991-03-28 |
| AU1876788A (en) | 1989-01-12 |
| DK375588A (da) | 1989-01-07 |
| DK375588D0 (da) | 1988-07-06 |
| NZ225274A (en) | 1991-07-26 |
| IE60914B1 (en) | 1994-08-24 |
| IL86951A (en) | 1996-07-23 |
| US5574024A (en) | 1996-11-12 |
| KR0126768B1 (ko) | 1998-04-03 |
| IL86951A0 (en) | 1988-12-30 |
| EP0298553B1 (de) | 1992-01-15 |
| IE882050L (en) | 1989-01-06 |
| DE3867736D1 (de) | 1992-02-27 |
| EP0298553A1 (de) | 1989-01-11 |
| JPS6485984A (en) | 1989-03-30 |
| ZA884792B (en) | 1989-05-30 |
| KR890002209A (ko) | 1989-04-10 |
| JP2859271B2 (ja) | 1999-02-17 |
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