ATE72582T1 - Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. - Google Patents

Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.

Info

Publication number: ATE72582T1
Authority: AT; Austria
Prior art keywords: muteins; beta; interferon; production; preparations containing
Prior art date: 1986-09-05

Application number

AT86306895T

Other languages

English (en)

Inventor

Alice M Wang

Ze Ev Shaked

Original Assignee

Cetus Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-05

Filing date

1986-09-05

Publication date

1992-02-15

1986-09-05 Application filed by Cetus Corp filed Critical Cetus Corp

1992-02-15 Application granted granted Critical

1992-02-15 Publication of ATE72582T1 publication Critical patent/ATE72582T1/de

Links

230000003647 oxidation Effects 0.000 title abstract 3
238000007254 oxidation reaction Methods 0.000 title abstract 3
108090000467 Interferon-beta Proteins 0.000 title abstract 2
102000003996 Interferon-beta Human genes 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 2
102100026720 Interferon beta Human genes 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000002978 peroxides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT86306895T 1986-09-05 1986-09-05 Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. ATE72582T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP86306895A EP0260350B1 (de)	1986-09-05	1986-09-05	Oxidationsresistente Muteine von beta-Interferon, deren Herstellung und diese Muteine enthaltende Präparate

Publications (1)

Publication Number	Publication Date
ATE72582T1 true ATE72582T1 (de)	1992-02-15

Family

ID=8196130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86306895T ATE72582T1 (de)	1986-09-05	1986-09-05	Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.

Country Status (3)

Country	Link
EP (1)	EP0260350B1 (de)
AT (1)	ATE72582T1 (de)
DE (1)	DE3683910D1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU9103791A (en) *	1990-12-21	1992-07-22	Allelix Biopharmaceuticals Inc.	Oxidation resistant variants of parathyroid hormone
US5977070A (en) *	1992-07-14	1999-11-02	Piazza; Christin Teresa	Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5589452A (en) *	1992-07-14	1996-12-31	Syntex (U.S.A.) Inc.	Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5545723A (en) *	1994-03-15	1996-08-13	Biogen Inc.	Muteins of IFN-β
US6531122B1 (en)	1999-08-27	2003-03-11	Maxygen Aps	Interferon-β variants and conjugates
US7144574B2 (en)	1999-08-27	2006-12-05	Maxygen Aps	Interferon β variants and conjugates
US7431921B2 (en)	1999-08-27	2008-10-07	Maxygen Aps	Interferon beta-like molecules
JP2004534523A (ja)	2001-02-27	2004-11-18	マキシゲン・エイピーエス	新規なインターフェロンβ様分子
DE60332358D1 (de)	2002-09-09	2010-06-10	Hanall Pharmaceutical Co Ltd	Protease-resistente modifizierte interferon alpha polypeptide
US8778880B2 (en)	2004-02-02	2014-07-15	Ambrx, Inc.	Human growth hormone modified at position 35
WO2007130453A2 (en) *	2006-05-02	2007-11-15	Allozyne, Inc.	Non-natural amino acid substituted polypeptides
EP2076533B1 (de)	2007-05-02	2014-10-08	Ambrx, Inc.	Modifizierte interferon-beta-polypeptide und ihre verwendungen
CN113683675A (zh) *	2020-05-19	2021-11-23	北京志道生物科技有限公司	干扰素-κ突变体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE56026B1 (en) *	1982-10-19	1991-03-27	Cetus Corp	Cysteine-depleted muteins of biologically active proteins
NZ208612A (en) *	1983-06-24	1991-09-25	Genentech Inc	Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
GB8317880D0 (en) *	1983-07-01	1983-08-03	Searle & Co	Structure and synthesis of interferons
DE3585969D1 (de) *	1984-06-14	1992-06-11	Chiron Corp	Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung.
EP0169114B1 (de) *	1984-06-19	1991-01-16	Transgene S.A.	Derivate des menschlichen alpha-1-Antitrypins und Verfahren zu deren Herstellung

1986
- 1986-09-05 EP EP86306895A patent/EP0260350B1/de not_active Expired
- 1986-09-05 AT AT86306895T patent/ATE72582T1/de not_active IP Right Cessation
- 1986-09-05 DE DE8686306895T patent/DE3683910D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0260350B1 (de)	1992-02-12
EP0260350A1 (de)	1988-03-23
DE3683910D1 (de)	1992-03-26

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Legal Events

Date	Code	Title
1992-11-15	UEP	Publication of translation of european patent specification
1999-01-15	EEIH	Change in the person of patent owner
2006-12-15	EELA	Cancelled due to lapse of time