ATE733T1 - 2'-DEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND ANTITUMORS COMPOSITIONS CONTAINING THEM. - Google Patents

2'-DEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND ANTITUMORS COMPOSITIONS CONTAINING THEM.

Info

Publication number
ATE733T1
ATE733T1 AT79301782T AT79301782T ATE733T1 AT E733 T1 ATE733 T1 AT E733T1 AT 79301782 T AT79301782 T AT 79301782T AT 79301782 T AT79301782 T AT 79301782T AT E733 T1 ATE733 T1 AT E733T1
Authority
AT
Austria
Prior art keywords
deoxy
fluorouridine
antitumors
preparation
compositions containing
Prior art date
Application number
AT79301782T
Other languages
German (de)
Inventor
Setsuro Fujii
Euechi Sakakibara
Original Assignee
Funai Pharmaceutical Ind., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Funai Pharmaceutical Ind., Ltd. filed Critical Funai Pharmaceutical Ind., Ltd.
Application granted granted Critical
Publication of ATE733T1 publication Critical patent/ATE733T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel 2 min -deoxy-5- fluorouridine derivatives represented by the formula; <CHEM> wherein R represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an acetyloxy group or a halogen atom, and n is an a integer in the range of 1 to 3 are provided. These have good antitumor activities and low toxicities and are suitable for use as antitumor agents. The new compounds may be prepared by reacting 2 min -deoxy-3 min ,5 min -di-0-acetyl-5- fluorouridine with a benzoyl halide of the formula; <CHEM> where hal is a halogen atom and R and n are as before, preferably in the presence of an organic base, particularly triethylamine and a solvent, particularly dioxane.
AT79301782T 1978-09-05 1979-08-31 2'-DEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND ANTITUMORS COMPOSITIONS CONTAINING THEM. ATE733T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10895578A JPS5535057A (en) 1978-09-05 1978-09-05 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
EP79301782A EP0009882B1 (en) 1978-09-05 1979-08-31 2'-deoxy-5-fluorouridine derivatives, a process for producing the same and antitumor agents comprising the same

Publications (1)

Publication Number Publication Date
ATE733T1 true ATE733T1 (en) 1982-03-15

Family

ID=14497883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79301782T ATE733T1 (en) 1978-09-05 1979-08-31 2'-DEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND ANTITUMORS COMPOSITIONS CONTAINING THEM.

Country Status (7)

Country Link
US (2) US4599404A (en)
EP (1) EP0009882B1 (en)
JP (1) JPS5535057A (en)
AT (1) ATE733T1 (en)
CA (1) CA1121811A (en)
DE (1) DE2962235D1 (en)
ES (1) ES483854A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5924999B2 (en) * 1978-06-10 1984-06-13 富山化学工業株式会社 Method for producing a novel 5-fluoro-2'-deoxy-β-uridine derivative
GB2072164B (en) * 1980-02-15 1983-12-21 Funai Pharmaceutical Ind Ltd 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
JPS6041924A (en) * 1984-07-17 1985-03-05 松下電器産業株式会社 beverage making machine
JPS6041922A (en) * 1984-07-17 1985-03-05 松下電器産業株式会社 Beverage maker
EP0436902B1 (en) * 1984-10-30 1995-06-28 Otsuka Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
JPH0678478B2 (en) * 1986-03-19 1994-10-05 ユニチカ株式会社 Thermoplastic resin composition
DE3786834T2 (en) * 1986-04-30 1994-03-03 Otsuka Pharma Co Ltd 5-fluoro-uracil derivatives.
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
US4981908A (en) * 1988-02-02 1991-01-01 E. I. Du Pont De Nemours And Company Thermoplastic elastomer blends
AU610344B2 (en) * 1988-02-29 1991-05-16 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
CN113234064B (en) * 2021-05-27 2022-03-29 西南医科大学附属中医医院 Tegafur derivative and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168513A (en) * 1962-03-02 1965-02-02 Hoffmann La Roche Derivative of 2'-deoxy-5-fluorouridine
US3309359A (en) * 1965-10-22 1967-03-14 Hoffmann La Roche N-mono-acyl-5-fluorocytosine derivatives and process
US3975367A (en) * 1971-06-08 1976-08-17 The Upjohn Company Arabinofuranosyl N4 -aminoacyl cytosine containing compounds
FR2306701A1 (en) * 1975-04-08 1976-11-05 Asahi Chemical Ind DERIVATIVES OF NUCLEOTIDES
DE2658672A1 (en) * 1976-12-23 1978-06-29 Robugen Gmbh Virustatic deoxy-uridine ether(s) - effective against RNA viruses, esp. 5-O-trityl-5-ethyl-2-deoxy-uridine

Also Published As

Publication number Publication date
US4490366A (en) 1984-12-25
EP0009882B1 (en) 1982-03-03
DE2962235D1 (en) 1982-04-01
US4599404A (en) 1986-07-08
JPS5535057A (en) 1980-03-11
CA1121811A (en) 1982-04-13
JPS5611718B2 (en) 1981-03-16
ES483854A1 (en) 1980-09-01
EP0009882A1 (en) 1980-04-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee