ATE74270T1 - Verwendung von thiophenverbindungen zur herstellung von medikamenten gegen tumore. - Google Patents
Verwendung von thiophenverbindungen zur herstellung von medikamenten gegen tumore.Info
- Publication number
- ATE74270T1 ATE74270T1 AT85202136T AT85202136T ATE74270T1 AT E74270 T1 ATE74270 T1 AT E74270T1 AT 85202136 T AT85202136 T AT 85202136T AT 85202136 T AT85202136 T AT 85202136T AT E74270 T1 ATE74270 T1 AT E74270T1
- Authority
- AT
- Austria
- Prior art keywords
- halogen
- thiophene
- preparation
- nitrophenoxy
- cpds
- Prior art date
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 p-nitrophenoxy Chemical group 0.000 abstract 2
- 229930192474 thiophene Natural products 0.000 abstract 2
- 101100439665 Arabidopsis thaliana SWI2 gene Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8424283A IT1196390B (it) | 1984-12-28 | 1984-12-28 | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE74270T1 true ATE74270T1 (de) | 1992-04-15 |
Family
ID=11212932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85202136T ATE74270T1 (de) | 1984-12-28 | 1985-12-24 | Verwendung von thiophenverbindungen zur herstellung von medikamenten gegen tumore. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4767758A (de) |
| EP (1) | EP0186252B1 (de) |
| JP (1) | JPS61180784A (de) |
| AT (1) | ATE74270T1 (de) |
| DE (1) | DE3585781D1 (de) |
| IT (1) | IT1196390B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196390B (it) * | 1984-12-28 | 1988-11-16 | Consiglio Nazionale Ricerche | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
| US5112954A (en) * | 1988-02-26 | 1992-05-12 | Neorx Corporation | Method of enhancing the effect of cytotoxic agents |
| DE3933573A1 (de) * | 1989-10-07 | 1991-04-18 | Basf Ag | Carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| DE69435137D1 (de) * | 1993-05-13 | 2008-10-16 | Poniard Pharmaceuticals Inc | Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind |
| ES2169773T3 (es) * | 1995-04-11 | 2002-07-16 | Mitsui Chemicals Inc | Derivados de tiofeno sustituido y fungicidas agricolas y horticolas que contienen dichos derivados como ingrediente activo. |
| US6136984A (en) * | 1996-04-22 | 2000-10-24 | Novo Nordisk A/S | Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes |
| WO1998046588A2 (en) * | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US6121202A (en) * | 1997-11-07 | 2000-09-19 | American Cyanamid Company | Thienyloxypyridines and-pyrimidines useful as herbicidal agents |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
| WO2006040569A1 (en) * | 2004-10-14 | 2006-04-20 | Astex Therapeutics Limited | Thiophene amide compounds for use in the treatment or prophylaxis of cancers |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2647120A (en) * | 1949-12-14 | 1953-07-28 | Du Pont | 5-nitro-2-thiophenecarboxamides |
| US2680117A (en) * | 1951-05-18 | 1954-06-01 | Du Pont | 5-nitro-2-substituted thiophenes and process |
| US2649461A (en) * | 1951-06-13 | 1953-08-18 | Du Pont | 5-nitro-2-thiophenecarboxaldehyde oxime |
| NL204495A (de) * | 1955-03-02 | |||
| US3639613A (en) * | 1968-08-28 | 1972-02-01 | Smith Kline French Lab | Composition and methods for controlling coccidiosis in poultry employing nitrothiophene derivatives |
| US3707480A (en) * | 1968-08-28 | 1972-12-26 | Smith Kline French Lab | Nitrothiophene dicarboxamides |
| US3839359A (en) * | 1970-09-23 | 1974-10-01 | Bayer Ag | 2-arylaminonitrothiophenes |
| US3733319A (en) * | 1970-01-07 | 1973-05-15 | Us Army | Nitrothiophenes |
| US3888986A (en) * | 1974-01-28 | 1975-06-10 | Schering Corp | Certain 1-(5-nitro-2-thienyl)-1-acylamidoalkanes for treating histomoniasis |
| GB1560699A (en) * | 1975-11-14 | 1980-02-06 | Hoffmann La Roche | 2-or 3-thienyl-polyenes |
| IT1140323B (it) * | 1981-12-09 | 1986-09-24 | Montedison Spa | Processo per la preparazione di composti carbossilati aromatici o etero-aromatici |
| IT1196390B (it) * | 1984-12-28 | 1988-11-16 | Consiglio Nazionale Ricerche | Uso di derivati del tiofene nel trattamento dei tumori,composizioni farmaceutiche che li contengono e composti atti allo scopo |
-
1984
- 1984-12-28 IT IT8424283A patent/IT1196390B/it active
-
1985
- 1985-12-24 DE DE8585202136T patent/DE3585781D1/de not_active Expired - Lifetime
- 1985-12-24 EP EP85202136A patent/EP0186252B1/de not_active Expired - Lifetime
- 1985-12-24 AT AT85202136T patent/ATE74270T1/de not_active IP Right Cessation
- 1985-12-27 JP JP60299676A patent/JPS61180784A/ja active Pending
-
1987
- 1987-02-26 US US07/020,162 patent/US4767758A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0186252B1 (de) | 1992-04-01 |
| US4767758A (en) | 1988-08-30 |
| EP0186252A2 (de) | 1986-07-02 |
| DE3585781D1 (de) | 1992-05-07 |
| EP0186252A3 (en) | 1987-05-06 |
| IT8424283A0 (it) | 1984-12-28 |
| IT1196390B (it) | 1988-11-16 |
| JPS61180784A (ja) | 1986-08-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3585781D1 (de) | Verwendung von thiophenverbindungen zur herstellung von medikamenten gegen tumore. | |
| ATE38835T1 (de) | Karbonsaeure-derivate verwendbar bei der verhuetung der zersetzung von knorpeln. | |
| ATE62595T1 (de) | Basische zubereitungen von chinoloncarbonsaeuren. | |
| DK232989D0 (da) | Antiviralt praeparat | |
| ES8204726A1 (es) | Procedimiento para la preparacion de acidos carboxilicos | |
| HUT44523A (en) | Process for producing new aromatic carboxamide derivatives and pharmaceutical compositions containing them as active components | |
| FI861506A0 (fi) | Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra). | |
| FI911286A0 (fi) | Kemiska foereningar. | |
| EP0279466A3 (en) | Novel naphthalene derivatives and antiallergy and anti-inflammatory pharmaceuticals | |
| DK248886D0 (da) | Spiro-imidazolidin-forbindelser og farmaceutiske praeparater indeholdende disse | |
| ES2075429T3 (es) | Derivados de 4,5-cicloalcano-3-benzazepin-7-ol y sus usos. | |
| DK451687D0 (da) | 2-guanidino-4-arylthiazol-forbindelser og farmaceutiske praeparater indeholdende disse | |
| MY100483A (en) | Niflumic acid morpholinoethyl ester diniflumate, preparation, use in therapeutics as analgesic and anti- inflammatory | |
| ES2148215T3 (es) | Sintesis de 2-hidroxi-acidos homoquirales. | |
| SG58291G (en) | Anticonvulsant agents | |
| AU6101686A (en) | Derivatives of 1-dethia 2-thia cephalosporanic acid and their salts, their preparation process and their use as medicaments | |
| FR2263750A1 (en) | N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc. | |
| FR2372816A1 (fr) | Benzisothiazolones et medicaments contenant ces substances | |
| GR3035097T3 (en) | Acyl substituted aminopyrans with a modulating effect on calcium channels | |
| ES8800930A1 (es) | Un metodo de preparacion de un compuesto de oxodiazina | |
| ATE50564T1 (de) | Heterocyclische verbindungen. | |
| IT1037040B (it) | Procedimento per la preparazione di esteri di immidoacidi ciclici | |
| FR2311020A1 (fr) | Derives de l'acide 6-aminopenicillanique et procede d'obtention desdits derives | |
| BE803618A (en) | Thiocarbamate sulphoxides and sulphones as herbicides - obtd by oxidn of corresponding thiocarbamate using eg m-chloroperoxy-benzoic acid | |
| IT1105710B (it) | Procedimento e composti intermedi per produrre 4'-2-carbossietilfenil-trans-4-amminometil-cicloesancarbossilato e suoi derivati |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |