ATE75739T1 - PROCESS FOR THE PRODUCTION OF DIBENZOTHIOPINE DERIVATIVES. - Google Patents

PROCESS FOR THE PRODUCTION OF DIBENZOTHIOPINE DERIVATIVES.

Info

Publication number
ATE75739T1
ATE75739T1 AT87308655T AT87308655T ATE75739T1 AT E75739 T1 ATE75739 T1 AT E75739T1 AT 87308655 T AT87308655 T AT 87308655T AT 87308655 T AT87308655 T AT 87308655T AT E75739 T1 ATE75739 T1 AT E75739T1
Authority
AT
Austria
Prior art keywords
dibenzothiopine
derivatives
production
derivative
converted
Prior art date
Application number
AT87308655T
Other languages
German (de)
Inventor
Mitsuo Masaki
Hiromitsu Takeda
Naoya Moritoh
Toshihiro Takahashi
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Application granted granted Critical
Publication of ATE75739T1 publication Critical patent/ATE75739T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A novel process for the preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): <CHEM> wherein R<1> is hydrogen or a lower alkyl group, which is once converted into a haloacetal compound via a haloketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequences.
AT87308655T 1987-09-30 1987-09-30 PROCESS FOR THE PRODUCTION OF DIBENZOTHIOPINE DERIVATIVES. ATE75739T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87308655A EP0309626B1 (en) 1987-09-30 1987-09-30 Process for the preparation of dibenzothiepin derivative

Publications (1)

Publication Number Publication Date
ATE75739T1 true ATE75739T1 (en) 1992-05-15

Family

ID=8198054

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87308655T ATE75739T1 (en) 1987-09-30 1987-09-30 PROCESS FOR THE PRODUCTION OF DIBENZOTHIOPINE DERIVATIVES.

Country Status (5)

Country Link
EP (1) EP0309626B1 (en)
AT (1) ATE75739T1 (en)
AU (1) AU590450B2 (en)
DE (1) DE3778896D1 (en)
ES (1) ES2032834T3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022289A1 (en) * 1995-01-20 1996-07-25 Nippon Chemiphar Co., Ltd. Process for producing dibenzothiepin derivative
JP3493288B2 (en) * 1996-08-22 2004-02-03 日本ケミファ株式会社 Method for producing 2- (10,11-dihydro-10-oxodibenzo [b, f] thiepin-2-yl) propionic acid and intermediate compound thereof
KR100730767B1 (en) * 2001-12-06 2007-06-21 코오롱생명과학 주식회사 New preparation method of dibenzothione derivatives
CN100462362C (en) * 2005-12-20 2009-02-18 常州市康瑞化工有限公司 Preparing process of 2-(10-oxy-10,11-dihydrodibenz [b,f]-thiotropilium-2-yl) propionic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553282A (en) * 1978-10-17 1980-04-18 Nippon Chemiphar Co Ltd Dibenzothiepin derivative and its preparation
JPS57106678A (en) * 1980-12-23 1982-07-02 Nippon Chemiphar Co Ltd Preparation of dibenzothiepinpropionic acid derivative
JPS58113168A (en) * 1981-12-28 1983-07-05 Fuji Photo Film Co Ltd Production of 5-(1-carboxyethyl)-2-phenylthiophenyl- acetic acid

Also Published As

Publication number Publication date
ES2032834T3 (en) 1993-03-01
AU7926287A (en) 1989-04-06
DE3778896D1 (en) 1992-06-11
AU590450B2 (en) 1989-11-02
EP0309626A1 (en) 1989-04-05
EP0309626B1 (en) 1992-05-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee