ATE75942T1 - Verwendung von 2-amino-4-morpholino-6-propyl1,3,5-triazin zur herstellung eines medikaments zur behandlung kognitiver und mentaler erkrankungen. - Google Patents

Verwendung von 2-amino-4-morpholino-6-propyl1,3,5-triazin zur herstellung eines medikaments zur behandlung kognitiver und mentaler erkrankungen.

Info

Publication number: ATE75942T1
Authority: AT; Austria
Prior art keywords: alkyl; morpholino; cognitive; triazine; amino
Prior art date: 1988-08-16

Application number

AT89870119T

Other languages

English (en)

Inventor

Ernst Wuelfert

Jean Gobert

Eric Cossement

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-16

Filing date

1989-07-28

Publication date

1992-05-15

1989-07-28 Application filed by Ucb Sa filed Critical Ucb Sa

1992-05-15 Application granted granted Critical

1992-05-15 Publication of ATE75942T1 publication Critical patent/ATE75942T1/de

Links

GOIPIEMTOZZMNH-UHFFFAOYSA-N 4-morpholin-4-yl-6-propyl-1,3,5-triazin-2-amine Chemical compound CCCC1=NC(N)=NC(N2CCOCC2)=N1 GOIPIEMTOZZMNH-UHFFFAOYSA-N 0.000 title abstract 2
230000001149 cognitive effect Effects 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000003340 mental effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010012289 Dementia Diseases 0.000 abstract 1
101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
230000032683 aging Effects 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000004171 alkoxy aryl group Chemical group 0.000 abstract 1
125000002877 alkyl aryl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000006213 aryl hydroxyalkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
230000003542 behavioural effect Effects 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
-1 halogenoaryl Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000005350 hydroxycycloalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT89870119T 1988-08-16 1989-07-28 Verwendung von 2-amino-4-morpholino-6-propyl1,3,5-triazin zur herstellung eines medikaments zur behandlung kognitiver und mentaler erkrankungen. ATE75942T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB888819494A GB8819494D0 (en)	1988-08-16	1988-08-16	Use of 2-amino-4-morpholino-6-propyl-1 3 5-triazines for preparation of psychotropic medicaments
EP89870119A EP0356412B1 (de)	1988-08-16	1989-07-28	Verwendung von 2-Amino-4-morpholino-6-propyl-1,3,5-triazin zur Herstellung eines Medikaments zur Behandlung kognitiver und mentaler Erkrankungen

Publications (1)

Publication Number	Publication Date
ATE75942T1 true ATE75942T1 (de)	1992-05-15

Family

ID=10642236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89870119T ATE75942T1 (de)	1988-08-16	1989-07-28	Verwendung von 2-amino-4-morpholino-6-propyl1,3,5-triazin zur herstellung eines medikaments zur behandlung kognitiver und mentaler erkrankungen.

Country Status (15)

Country	Link
US (1)	US4956363A (de)
EP (1)	EP0356412B1 (de)
JP (1)	JPH02108676A (de)
KR (1)	KR0137660B1 (de)
AT (1)	ATE75942T1 (de)
AU (1)	AU616140B2 (de)
CA (1)	CA1329772C (de)
DE (1)	DE68901511D1 (de)
DK (1)	DK398289A (de)
GB (1)	GB8819494D0 (de)
IE (1)	IE61828B1 (de)
IL (1)	IL91244A (de)
MY (1)	MY104150A (de)
PH (1)	PH26119A (de)
ZA (1)	ZA896223B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9024617D0 (en) *	1989-12-05	1991-01-02	Ici Plc	Heterocyclic compounds
GB9008818D0 (en) *	1990-04-19	1990-06-13	Ici Plc	Amine derivatives
FR2665636B1 (fr) *	1990-08-10	1994-10-07	Adir	Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer.
GB9116039D0 (en) *	1991-07-25	1991-09-11	Ucb Sa	Substituted cyclopropylamino-1,3,5-triazines
DE19531084A1 (de)	1995-08-24	1997-02-27	Hoechst Schering Agrevo Gmbh	2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
EP1185528A4 (de) *	1999-06-17	2003-03-26	Shionogi Biores Corp	Inhibitoren der il-12 herstellung
US20060004005A1 (en) *	2003-09-25	2006-01-05	Sattigeri Viswajanani J	Triazines derivatives as cell adhesion inhibitors
TW200628159A (en) *	2004-11-10	2006-08-16	Synta Pharmaceuticals Corp	IL-12 modulatory compounds
AU2010206886B2 (en)	2009-01-20	2016-05-05	Los Angeles Biomedical Research Institute At Harbor - Ucla Medical Center	Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical
WO2016204988A1 (en) *	2015-06-18	2016-12-22	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Autophagy modulators for treating neurodegenerative diseases
CN109563024B (zh)	2016-06-13	2023-06-06	心悦生医股份有限公司	苯甲酸锂的共晶及其用途
WO2017215593A1 (en)	2016-06-13	2017-12-21	Syneurx International (Taiwan) Corp.	Co-crystals of sodium benzoate and uses thereof
US11369579B2 (en)	2016-10-24	2022-06-28	Syneurx International (Taiwan) Corp.	Polymorphic forms of sodium benzoate and uses thereof
US10336679B2 (en)	2016-10-24	2019-07-02	Syneurx International (Taiwan) Corp.	Polymorphic forms of sodium benzoate and uses thereof
US10098861B1 (en)	2017-10-24	2018-10-16	Syneurx International (Taiwan) Corp.	Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3549755A (en) *	1968-03-27	1970-12-22	Shell Oil Co	Use of 2-trichloromethyl-4-morpholinoor piperazino-6-substituted-s-triazines for inducing depressant effects in animals
FR2262512A1 (en) *	1974-03-01	1975-09-26	Synthelabo	2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity

1988
- 1988-08-16 GB GB888819494A patent/GB8819494D0/en active Pending
1989
- 1989-07-28 AT AT89870119T patent/ATE75942T1/de not_active IP Right Cessation
- 1989-07-28 DE DE8989870119T patent/DE68901511D1/de not_active Expired - Lifetime
- 1989-07-28 EP EP89870119A patent/EP0356412B1/de not_active Expired - Lifetime
- 1989-08-08 US US07/309,877 patent/US4956363A/en not_active Expired - Fee Related
- 1989-08-08 IL IL9124489A patent/IL91244A/en not_active IP Right Cessation
- 1989-08-09 MY MYPI89001087A patent/MY104150A/en unknown
- 1989-08-09 CA CA000607833A patent/CA1329772C/en not_active Expired - Fee Related
- 1989-08-09 PH PH39076A patent/PH26119A/en unknown
- 1989-08-14 DK DK398289A patent/DK398289A/da not_active Application Discontinuation
- 1989-08-15 AU AU39918/89A patent/AU616140B2/en not_active Ceased
- 1989-08-15 ZA ZA896223A patent/ZA896223B/xx unknown
- 1989-08-15 JP JP1210548A patent/JPH02108676A/ja active Pending
- 1989-08-15 IE IE262089A patent/IE61828B1/en not_active IP Right Cessation
- 1989-08-16 KR KR1019890011697A patent/KR0137660B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL91244A0 (en)	1990-03-19
CA1329772C (en)	1994-05-24
GB8819494D0 (en)	1988-09-21
DE68901511D1 (de)	1992-06-17
AU3991889A (en)	1990-02-22
IE892620L (en)	1990-02-16
PH26119A (en)	1992-02-24
KR900002780A (ko)	1990-03-23
ZA896223B (en)	1990-05-30
EP0356412B1 (de)	1992-05-13
IL91244A (en)	1994-07-31
JPH02108676A (ja)	1990-04-20
AU616140B2 (en)	1991-10-17
MY104150A (en)	1994-02-28
EP0356412A1 (de)	1990-02-28
DK398289D0 (da)	1989-08-14
US4956363A (en)	1990-09-11
DK398289A (da)	1990-02-17
IE61828B1 (en)	1994-11-30
KR0137660B1 (ko)	1998-05-15

Legal Events

Date	Code	Title	Description
1992-12-15	UEP	Publication of translation of european patent specification
2000-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE75942T1 (de)	1992-05-15	Verwendung von 2-amino-4-morpholino-6-propyl1,3,5-triazin zur herstellung eines medikaments zur behandlung kognitiver und mentaler erkrankungen.
DE69121561D1 (de)	1996-09-26	Verwendung von 3-guanidinopropionsäure zur herstellung eines medikaments zur behandlung und prävention von fettsucht
DE3684190D1 (de)	1992-04-16	Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
DE59100830D1 (de)	1994-02-24	Verfahren zur Herstellung von 3-Aminomethyl-3,5,5,-trimethyl-cyclohexylamin.
ATE108453T1 (de)	1994-07-15	Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.
ATE191849T1 (de)	2000-05-15	Verwendung von (s)-(-)-alpha-ethyl-2-oxo-1- pyrrolidinacetamid zur herstellung eines medikaments zur behandlung von angst
DE59006868D1 (de)	1994-09-29	2-Alkyl-4-arylmethylaminochinoline, ihre Verwendung und daraus hergestellte Arzneimittel.
DK511383D0 (da)	1983-11-08	Fremgangsmade til fremstilling af piperidindionderivater,der beskytter hjertemuskulaturen med en antiarythmisk aktivitet
ATE72241T1 (de)	1992-02-15	2-amino-4-morpholino-6-propyl-1,3,5-triazine.
ATE79371T1 (de)	1992-08-15	Derivate des cysteins, verfahren zur herstellung und verwendung davon.
ATE263565T1 (de)	2004-04-15	Verwendung von 8,9-dehydroestron zur herstellung eines arzneimittels zur behandlung von durch freie radikale verursachte krankheiten
DE68902627D1 (de)	1992-10-01	Verwendung von chromanderivaten zur herstellung eines medikamentes zur behandlung von depressiven zustaenden.
DE69021557D1 (de)	1995-09-14	Verwendung von derivaten von 9,10-dihydrophenanthren zur herstellung eines antitumoralen medikamentes und neuen derivaten daraus.
DE68920493D1 (de)	1995-02-23	Verfahren zur Herstellung von Derivaten von 2'-Deoxy-beta-cytidin und Salze davon.
PT77880B (de)	1986-04-09	Neue 6alpha-methylprednisolon-derivate ihre herstellung und verwendung
TH9795A (th)	1991-11-01	1-(1h-อิมิดาซอล-4-อิล)อัลคิลเบนซามีตที่ถูกแทนที่