ATE78297T1 - Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen. - Google Patents

Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen.

Info

Publication number: ATE78297T1
Authority: AT; Austria
Prior art keywords: dkg; klg; expresses; fermentation; precursor
Prior art date: 1985-08-02

Application number

AT86905045T

Other languages

English (en)

Inventor

Kimber Hardy

De Pol Hendrick Van

June Grindley

Mark A Payton

Original Assignee

Biogen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-02

Filing date

1986-08-01

Publication date

1992-08-15

1985-08-02 Priority claimed from GB858519536A external-priority patent/GB8519536D0/en

1986-08-01 Application filed by Biogen Inc filed Critical Biogen Inc

1992-08-15 Application granted granted Critical

1992-08-15 Publication of ATE78297T1 publication Critical patent/ATE78297T1/de

Links

CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 3
235000003869 genetically modified organism Nutrition 0.000 title abstract 2
239000002243 precursor Substances 0.000 title abstract 2
VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 abstract 5
VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 abstract 5
108090000790 Enzymes Proteins 0.000 abstract 5
102000004190 Enzymes Human genes 0.000 abstract 5
230000004151 fermentation Effects 0.000 abstract 4
238000000855 fermentation Methods 0.000 abstract 4
241000588699 Erwinia sp. Species 0.000 abstract 3
241000186249 Corynebacterium sp. Species 0.000 abstract 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
239000008103 glucose Substances 0.000 abstract 2
108010086063 2,5-diketo-D-gluconate 5-reductase Proteins 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01274—2,5-Didehydrogluconate reductase (1.1.1.274), i.e. 2,5-diketo-D-gluconic acid reductase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
Joining Of Building Structures In Genera (AREA)
Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)

AT86905045T 1985-08-02 1986-08-01 Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen. ATE78297T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB858519536A GB8519536D0 (en)	1985-08-02	1985-08-02	Vitamin c precursor
US79243285A	1985-10-29	1985-10-29
EP86905045A EP0231354B1 (de)	1985-08-02	1986-08-01	Herstellung eines vitamin-c-vorläufers mittels genetisch modifizierter organismen
PCT/US1986/001571 WO1987000863A1 (en)	1985-08-02	1986-08-01	Production of a vitamin c precursor using genetically modified organisms

Publications (1)

Publication Number	Publication Date
ATE78297T1 true ATE78297T1 (de)	1992-08-15

Family

ID=26289601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86905045T ATE78297T1 (de)	1985-08-02	1986-08-01	Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen.

Country Status (7)

Country	Link
EP (1)	EP0231354B1 (de)
JP (4)	JPH0817706B2 (de)
AT (1)	ATE78297T1 (de)
AU (1)	AU594080B2 (de)
DE (1)	DE3686041T2 (de)
DK (1)	DK175120B1 (de)
WO (1)	WO1987000863A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008193A (en) *	1984-06-14	1991-04-16	Genentech, Inc.	Ascorbic acid intermediates and process enzymes
US5032514A (en) *	1988-08-08	1991-07-16	Genentech, Inc.	Metabolic pathway engineering to increase production of ascorbic acid intermediates
US5376544A (en) *	1992-09-08	1994-12-27	Rutgers The State University Of New Jersey	Enzymes for the production of 2-keto-L-gulonic acid
US5795761A (en) *	1996-01-11	1998-08-18	Rutgers, The State University Of New Jersey	Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
US6916646B1 (en) *	1997-06-23	2005-07-12	Genencor International, Inc.	Enterobacteriaceae fermentation strains
US6187732B1 (en)	1998-09-03	2001-02-13	Genencor International, Inc.	Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
US6407046B1 (en)	1998-09-03	2002-06-18	Genencor International, Inc.	Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
US6358715B1 (en)	1998-12-04	2002-03-19	Genencor International, Inc.	Production of ascorbic acid
US6576452B1 (en)	2000-10-04	2003-06-10	Genencor International, Inc.	2,5-diketo-L-gluconic acid reductases and methods of use
CN112430560B (zh) *	2019-08-26	2024-01-05	中国科学院分子植物科学卓越创新中心	一种2-酮基-l-古龙酸生产菌株及其构建方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57186496A (en) *	1981-05-11	1982-11-16	Ajinomoto Co Inc	Preparation of l-threonine by fermentation
DE3484216D1 (de) *	1983-06-28	1991-04-11	Genentech Inc	Biosynthetische 2,5-diketogluconsaeurereduktase, verfahren, rekombinante zellen und expressionsvektoren fuer ihre herstellung und ihre verwendung zur bereitung von 2-keto-l-gulonsaeure.
JPS60118186A (ja) *	1983-11-17	1985-06-25	Shionogi & Co Ltd	２・５−ジケト−ｄ−グルコン酸リダクタ−ゼ

1986
- 1986-08-01 EP EP86905045A patent/EP0231354B1/de not_active Expired - Lifetime
- 1986-08-01 AT AT86905045T patent/ATE78297T1/de not_active IP Right Cessation
- 1986-08-01 JP JP61504243A patent/JPH0817706B2/ja not_active Expired - Lifetime
- 1986-08-01 DE DE8686905045T patent/DE3686041T2/de not_active Expired - Lifetime
- 1986-08-01 WO PCT/US1986/001571 patent/WO1987000863A1/en not_active Ceased
- 1986-08-01 AU AU62210/86A patent/AU594080B2/en not_active Ceased
1987
- 1987-04-02 DK DK198701694A patent/DK175120B1/da not_active IP Right Cessation
1994
- 1994-03-28 JP JP6057610A patent/JP2526021B2/ja not_active Expired - Lifetime
1995
- 1995-06-28 JP JP7162718A patent/JP2577876B2/ja not_active Expired - Lifetime
- 1995-06-28 JP JP7162719A patent/JP2577877B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0231354A4 (de)	1988-10-06
JP2577877B2 (ja)	1997-02-05
JPH0838185A (ja)	1996-02-13
DK175120B1 (da)	2004-06-07
AU6221086A (en)	1987-03-05
JP2577876B2 (ja)	1997-02-05
DE3686041T2 (de)	1993-01-28
JPH0817706B2 (ja)	1996-02-28
DE3686041D1 (de)	1992-08-20
EP0231354A1 (de)	1987-08-12
JPS63500493A (ja)	1988-02-25
DK169487D0 (da)	1987-04-02
AU594080B2 (en)	1990-03-01
JPH06319564A (ja)	1994-11-22
EP0231354B1 (de)	1992-07-15
JPH0838189A (ja)	1996-02-13
JP2526021B2 (ja)	1996-08-21
WO1987000863A1 (en)	1987-02-12
DK169487A (da)	1987-04-02

Legal Events

Date	Code	Title
1993-01-15	UEP	Publication of translation of european patent specification
2001-01-15	EEIH	Change in the person of patent owner
2006-11-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
FI861198A0 (fi)	1986-03-21	Insulin precursorer, foerfarande foer framstaellning av dem och foerfarande foer framstaellning av maenniskoinsulin.
AU5359986A (en)	1986-08-13	Method of producing high molecular weight sodium hyaluronate by fermentation of streptococcus
IS3334A7 (is)	1988-10-16	Gerfrumur, aðferð til að framleiða þær og notkun þeirra
ATE78297T1 (de)	1992-08-15	Herstellung eines vitamin-c-vorlaeufers mittels genetisch modifizierter organismen.
FI951046A0 (fi)	1995-03-07	Parannettuja entsyymejä 2-keto-L-gulonihapon tuotantoon
GB1454249A (en)	1976-11-03	Process for preparing 2-keto-l-gulonic acid
ATE45769T1 (de)	1989-09-15	Herstellung von butanol mittels eines verbesserten gaerverfahrens.
DE60127470D1 (de)	2007-05-03	Herstellung von Ascorbinsäure in Hefen
Hardman et al.	1960	METABOLISM OF ω-AMINO ACIDS: II. Fermentation of Δ-Aminovaleric Acid by Clostridium aminovalericum n. sp.
Garrard et al.	1968	Regulation of Staphylococcus aureus lactate dehydrogenase
US6242233B1 (en)	2001-06-05	Aldehyde dehydrogenase
IE830487L (en)	1983-09-05	Preparing 2-keto-l-gulonic acid
ES8507607A1 (es)	1985-09-16	Procedimiento para la fabricacion de la reductasa del acido 2, 5-diceto-d-gluconico
Stadtman	1960	Synthesis of adenine-B12 coenzyme by Clostridium sticklandii: relationship to one-carbon metabolism
Barkulis	1953	Inhibition of the anaerobic pyruvate metabolism of Escherichia coli by dihydrostreptomycin
Rosenberg et al.	1993	Optimization of sorbose production from sorbitol by Gluconobacter oxydans
GB1233127A (de)	1971-05-26
US20050153412A1 (en)	2005-07-14	Aldehyde dehydrogenase II
SUZUKI et al.	1960	Conversion of L-gulonolactone to L-ascorbic acid; properties of the microsomal enzyme in rat liver
Fewson et al.	1968	Metabolism of monofluorobenzoates by Bacterium NCIB 8250
HORIO et al.	1954	STUDIES ON THE ACTION-PATTERN OF ANTITUBERCULAR SUBSTANCES IV. ON THE METABOLISM OF MALONIG ACID BY MYCOBACTERIUM TUBERCULOSIS AVIUM
JPS55102394A (en)	1980-08-05	Novel enzymatic preparation of dopamine
EP0322723A3 (de)	1990-05-16	Herstellung von Gluconsäure und Sorbitol
Brown	1961	The tricarboxylic acid cycle in Nocardia corallina
ES8800983A1 (es)	1987-12-16	Procedimiento para producir un microorganismo recombinante capaz de convertir glucosa u otro metabolico ordinario en acido 2-ceto-l-gulonico.