ATE78832T1 - Cyclosporine. - Google Patents

Cyclosporine.

Info

Publication number
ATE78832T1
ATE78832T1 AT86810112T AT86810112T ATE78832T1 AT E78832 T1 ATE78832 T1 AT E78832T1 AT 86810112 T AT86810112 T AT 86810112T AT 86810112 T AT86810112 T AT 86810112T AT E78832 T1 ATE78832 T1 AT E78832T1
Authority
AT
Austria
Prior art keywords
residue
formula
cyclosporins
mebmt
protonated
Prior art date
Application number
AT86810112T
Other languages
English (en)
Inventor
Dieter Seebach
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27262613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE78832(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506230A external-priority patent/GB8506230D0/en
Priority claimed from GB858511029A external-priority patent/GB8511029D0/en
Priority claimed from GB868602370A external-priority patent/GB8602370D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE78832T1 publication Critical patent/ATE78832T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
AT86810112T 1985-03-11 1986-03-06 Cyclosporine. ATE78832T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858506230A GB8506230D0 (en) 1985-03-11 1985-03-11 Organic compounds
GB858511029A GB8511029D0 (en) 1985-05-01 1985-05-01 Organic compounds
GB868602370A GB8602370D0 (en) 1986-01-31 1986-01-31 Organic compounds
EP86810112A EP0194972B1 (de) 1985-03-11 1986-03-04 Cyclosporine

Publications (1)

Publication Number Publication Date
ATE78832T1 true ATE78832T1 (de) 1992-08-15

Family

ID=27262613

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86810112T ATE78832T1 (de) 1985-03-11 1986-03-06 Cyclosporine.

Country Status (16)

Country Link
US (2) US4703033A (de)
EP (1) EP0194972B1 (de)
JP (1) JPH0759594B2 (de)
KR (1) KR860007285A (de)
AT (1) ATE78832T1 (de)
AU (1) AU588860B2 (de)
DE (1) DE3686183T2 (de)
DK (1) DK109486A (de)
ES (2) ES8900141A1 (de)
FI (1) FI860993A7 (de)
GR (1) GR860646B (de)
HU (1) HUT47137A (de)
IL (1) IL78083A0 (de)
NZ (1) NZ215414A (de)
PH (1) PH22439A (de)
PT (1) PT82164B (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
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US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
US4885276A (en) * 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
GB2206119B (en) * 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
GB2207678A (en) * 1987-08-03 1989-02-08 Merck & Co Inc Novel immunosuppressive fluorinated cyclosporin analogs
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US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US5271935A (en) * 1988-02-05 1993-12-21 Hoechst Aktiengesellschaft Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical
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US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
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GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
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FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
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US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
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Family Cites Families (5)

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US4384996A (en) * 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
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EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4685566A (en) * 1985-12-24 1987-08-11 Manville Sales Corporation Sleeve-type carrier

Also Published As

Publication number Publication date
PT82164B (en) 1988-01-04
IL78083A0 (en) 1986-07-31
AU5448586A (en) 1986-09-18
DE3686183T2 (de) 1993-01-14
DK109486D0 (da) 1986-03-10
JPS61212599A (ja) 1986-09-20
NZ215414A (en) 1990-08-28
US4771122A (en) 1988-09-13
EP0194972A2 (de) 1986-09-17
DK109486A (da) 1986-09-12
JPH0759594B2 (ja) 1995-06-28
EP0194972B1 (de) 1992-07-29
DE3686183D1 (en) 1992-09-03
PT82164A (en) 1986-04-01
FI860993L (fi) 1986-09-12
ES557619A0 (es) 1988-07-16
ES8802527A1 (es) 1988-07-16
AU588860B2 (en) 1989-09-28
GR860646B (en) 1986-07-11
PH22439A (en) 1988-09-12
ES552855A0 (es) 1989-01-16
FI860993A7 (fi) 1986-09-12
FI860993A0 (fi) 1986-03-10
KR860007285A (ko) 1986-10-10
EP0194972A3 (en) 1989-07-12
US4703033A (en) 1987-10-27
HUT47137A (en) 1989-01-30
ES8900141A1 (es) 1989-01-16

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