ATE79024T1 - Implantate zur abgabe biologisch aktiver makromolekuele. - Google Patents

Implantate zur abgabe biologisch aktiver makromolekuele.

Info

Publication number
ATE79024T1
ATE79024T1 AT87106859T AT87106859T ATE79024T1 AT E79024 T1 ATE79024 T1 AT E79024T1 AT 87106859 T AT87106859 T AT 87106859T AT 87106859 T AT87106859 T AT 87106859T AT E79024 T1 ATE79024 T1 AT E79024T1
Authority
AT
Austria
Prior art keywords
implants
delivery
biologically active
active macromolecules
macromolecules
Prior art date
Application number
AT87106859T
Other languages
English (en)
Inventor
Paul Y Wang
Original Assignee
Paul Y Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4133165&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE79024(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paul Y Wang filed Critical Paul Y Wang
Application granted granted Critical
Publication of ATE79024T1 publication Critical patent/ATE79024T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT87106859T 1986-05-20 1987-05-12 Implantate zur abgabe biologisch aktiver makromolekuele. ATE79024T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA000509526A CA1257199A (en) 1986-05-20 1986-05-20 Preparation containing bioactive macromolecular substance for multi-months release in vivo
EP87106859A EP0246540B1 (de) 1986-05-20 1987-05-12 Implantate zur Abgabe biologisch aktiver Makromoleküle

Publications (1)

Publication Number Publication Date
ATE79024T1 true ATE79024T1 (de) 1992-08-15

Family

ID=4133165

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87106859T ATE79024T1 (de) 1986-05-20 1987-05-12 Implantate zur abgabe biologisch aktiver makromolekuele.

Country Status (10)

Country Link
US (2) US5110595A (de)
EP (1) EP0246540B1 (de)
JP (1) JPS6322012A (de)
AT (1) ATE79024T1 (de)
AU (1) AU603793B2 (de)
CA (1) CA1257199A (de)
DE (1) DE3780862T2 (de)
DK (1) DK251287A (de)
ES (1) ES2051707T3 (de)
GR (1) GR3005395T3 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863736A (en) * 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
US5688519A (en) * 1987-04-06 1997-11-18 Leonard; Robert J. Flash-flow fused medicinal implants
DE68924808D1 (de) * 1988-07-26 1995-12-21 Univ Rutgers Vorrichtungen und Verfahren zur Wachstumsförderung bei Bratgeflügel.
DE68915784T2 (de) * 1989-03-09 1994-09-29 Endocom, Inc., Boston, Mass. Teilweise geschmolzenes peptidpellet.
DE3919982A1 (de) * 1989-06-19 1990-12-20 Liedtke Pharmed Gmbh Orale lipidarzneiform
WO1991005548A1 (en) * 1989-10-10 1991-05-02 Pitman-Moore, Inc. Sustained release composition for macromolecular proteins
NZ237084A (en) * 1990-02-12 1993-10-26 Lucky Ltd Composition for the prolonged release of somatotropin comprising the somatotropin, a tocopherol component, and an assistant delaying agent
AU1442592A (en) * 1991-02-20 1992-09-15 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
SG47955A1 (en) * 1991-06-24 1998-04-17 American Cyanamid Co Implant compositions containing a biologically active protein peptide or polypeptide
US5801141A (en) * 1991-06-24 1998-09-01 American Cyanamid Company Implant compositions containing a biologically active protein, peptide or polypeptide
YU87892A (sh) * 1991-10-01 1995-12-04 Eli Lilly And Company Lilly Corporate Center Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu
US5374616A (en) * 1991-10-18 1994-12-20 Georgetown University Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor
KR100260632B1 (ko) * 1992-12-28 2000-07-01 성재갑 이식형 소마토트로핀 조성물
TW282403B (de) * 1993-08-26 1996-08-01 Takeda Pharm Industry Co Ltd
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US5449679A (en) * 1994-07-29 1995-09-12 Leonard; Robert J. Process and products for reducing biological fluid levels of a lipid soluble waste
US6015821A (en) * 1995-05-01 2000-01-18 Horrobin; David Frederick Nicotinic acid esters and pharmaceutical compositions containing them
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
MY118354A (en) * 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
AUPN366795A0 (en) * 1995-06-20 1995-07-13 Peptide Technology Limited Formulation for preventing reproductive function
US5827904A (en) * 1996-09-27 1998-10-27 Hahn; David Medical implant composition
GB9705102D0 (en) * 1997-03-12 1997-04-30 Scotia Holdings Inc Presentation of fatty acids
US5874098A (en) * 1997-05-28 1999-02-23 Ivy Laboratories, Inc. Pellet implant system
GB9723068D0 (en) * 1997-10-31 1998-01-07 Patel Atulkumar S A skin-moisturing preparation
KR19990071255A (ko) 1998-02-28 1999-09-15 성재갑 소마토트로핀과 비타민의 합제 조성물
CA2335058A1 (en) 1998-06-22 1999-12-29 Danforth Joslyn Method, implant and delivery system for enhancing blood flow in tissue
US20010033839A1 (en) * 1999-10-04 2001-10-25 Emilio Barbera-Guillem Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation
US6488649B1 (en) 1998-11-24 2002-12-03 Edward M. Lichten Implant device
PL351948A1 (en) * 1999-06-04 2003-07-14 Alza Corp Implantable gel compositions and method of making thereof
JP2001058955A (ja) * 1999-06-17 2001-03-06 Inst Of Physical & Chemical Res 生理活性ペプチド徐放性製剤
US6984469B2 (en) 2000-09-25 2006-01-10 Samsung Sdi Co., Ltd. Positive active material for rechargeable lithium batteries and method of preparing same
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
KR100989647B1 (ko) * 2001-09-24 2010-10-26 오레곤 헬스 앤드 사이언스 유니버시티 식습관의 변화
US8058233B2 (en) * 2002-01-10 2011-11-15 Oregon Health And Science University Modification of feeding behavior using PYY and GLP-1
EP1474163A2 (de) 2002-01-10 2004-11-10 Imperial College Innovations Limited Veränderung des fütterungsverhaltens
GB0300571D0 (en) * 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
KR100486028B1 (ko) * 2004-04-20 2005-05-03 주식회사 펩트론 단백질 함유 서방성 리피드 임플란트 및 이의 제조방법
BRPI0513508B1 (pt) * 2004-07-19 2021-06-01 Biocon Limited Conjugados de insulina-oligômero, formulações e usos desses
PT1781264E (pt) * 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
GB0511986D0 (en) * 2005-06-13 2005-07-20 Imp College Innovations Ltd Novel compounds and their effects on feeding behaviour
RU2485135C2 (ru) 2005-06-13 2013-06-20 Импиэриэл Инноувейшнс Лимитид Соединения оксинтомодулина (варианты), фармацевтическая композиция на их основе, способы лечения и профилактики ожирения и сопутствующих заболеваний (варианты) и лекарственное средство (варианты)
EP2695896B1 (de) 2006-10-06 2018-08-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Prävention von Gewebeischämie, damit in Zusammenhang stehende Verfahren und Zusammensetzungen
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
CN101970475A (zh) 2007-07-09 2011-02-09 帝国改革有限公司 人类胰多肽(hpp)类似物及其对摄食行为的作用
JP5868594B2 (ja) 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 経口投与可能な固形医薬組成物及びそのプロセス
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
JP2010229284A (ja) 2009-03-27 2010-10-14 Fujifilm Corp 光硬化性組成物
GB0918579D0 (en) 2009-10-22 2009-12-09 Imp Innovations Ltd Gadd45beta targeting agents
GB201001333D0 (en) 2010-01-27 2010-03-17 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
GB201101459D0 (en) 2011-01-27 2011-03-16 Imp Innovations Ltd Novel compounds and thier effects on fedding behaviour
WO2013004983A1 (en) 2011-07-04 2013-01-10 Imperial Innovations Limited Novel compounds and their effects on feeding behaviour
WO2013039916A1 (en) 2011-09-12 2013-03-21 The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Compositions for and methods of treatment and enhanced detection of non-pituitary tumors
US9879012B2 (en) 2012-03-29 2018-01-30 Regents Of The University Of Colorado, A Body Corporate Click nucleic acids
WO2014160183A1 (en) 2013-03-13 2014-10-02 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity
BR112015032194A2 (pt) 2013-07-02 2017-07-25 Cortice Biosciences Inc método para tratar ou melhorar um ou mais sintomas de um distúrbio neurodegenerativo
CA2923835C (en) 2013-09-11 2022-11-29 The Administrators Of The Tulane Educational Fund Novel anthranilic amides and the use thereof
WO2015057583A1 (en) 2013-10-14 2015-04-23 The United States Of America, As Represented By The Secretary Treatment of chronic kidney disease with sahps
DE102013018193A1 (de) 2013-10-30 2015-05-13 Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts Injizierbare Depotformulierungen zur kontrollierten Wirkstofffreisetzung
DE102014005782A1 (de) 2014-04-23 2015-10-29 Martin-Luther-Universität Halle-Wittenberg lnjizierbare und implantierbare Trägersysteme auf Basis von modifizierten Poly(dikarbonsäure-multiol estern) zur kontrollierten Wirkstofffreisetzung
US20170137486A1 (en) 2014-05-23 2017-05-18 Imperial Innovations Limited Peptide yy (pyy) analogues
US10246463B2 (en) 2015-04-07 2019-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hypoxia-inducible factor 1 (HIF-1) inhibitors
GB201720188D0 (en) 2017-12-04 2018-01-17 Imperial Innovations Ltd Analogues of PYY
GB201908426D0 (en) 2019-06-12 2019-07-24 Imp College Innovations Ltd Appetite suppressing compounds
GB201908424D0 (en) 2019-06-12 2019-07-24 Imp College Innovations Ltd Novel compounds
US20240336669A1 (en) 2020-12-11 2024-10-10 Ip21Po Innovations Limteed Novel compounds
GB202217575D0 (en) 2022-11-24 2023-01-11 Imperial College Innovations Ltd Novel compounds
GB202302686D0 (en) 2023-02-24 2023-04-12 Imperial College Innovations Ltd Novel compounds
WO2025085868A2 (en) 2023-10-20 2025-04-24 Radiation Control Technologies, Inc. Cd47-targeting morpholinos
WO2025176999A2 (en) 2024-02-23 2025-08-28 Ip2Ipo Innovations Limited Novel compounds
WO2026064639A1 (en) 2024-09-20 2026-03-26 Zihipp Ltd Glp-1 receptor agonist compositions and methods of use thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895875A (en) * 1950-10-20 1959-07-21 Erich M H Radde Subcutaneous hormone pellets
US3312594A (en) * 1963-06-21 1967-04-04 Squibb & Sons Inc Longlasting troche
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
CA1076480A (en) * 1975-04-28 1980-04-29 John S. Kent Inert core implant pellet
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
US4180560A (en) * 1976-10-26 1979-12-25 Syntex Corporation Inert core implant pellet
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
GB2051574B (en) * 1979-05-10 1984-01-18 Kyoto Pharma Ind Adjuvant for promoting absorption of pharmacologically active substances through the rectum
US4279812A (en) * 1979-09-12 1981-07-21 Seton Company Process for preparing macromolecular biologically active collagen
JPS56122317A (en) * 1980-02-29 1981-09-25 Koken:Kk Drug transporting material and its preparation
JPS56138111A (en) * 1980-03-28 1981-10-28 Teijin Ltd Suppository containing unsaturated fatty acid or salt thereof
US4393041A (en) * 1980-04-25 1983-07-12 International Minerals & Chemical Corp. Fibrin binder/carrier for active biochemical agents
US4322323A (en) * 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
US4349530A (en) * 1980-12-11 1982-09-14 The Ohio State University Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
US4483807A (en) * 1981-01-27 1984-11-20 Japan Atomic Energy Research Institute Process for producing a slow release composite
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
SU1011126A1 (ru) * 1981-07-14 1983-04-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Средство дл лечени сахарного диабета
NL193099C (nl) * 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
DD212185A1 (de) * 1982-12-21 1984-08-08 Adw Ddr Verfahren zur herstellung von phospholipid-wirkstoff-kombinationen
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
US4882167A (en) * 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
DE3463211D1 (en) * 1983-07-01 1987-05-21 Battelle Memorial Institute Biodegradable polypeptide and its use in the sustained release of medicaments
US4774091A (en) * 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
EP0143949B1 (de) * 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmazeutische Zusammensetzung mit Gehalt an Urokinase
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
DE3413608A1 (de) * 1984-04-11 1985-10-24 Hoechst Ag, 6230 Frankfurt Implantierbare zubereitungen von regulatorischen peptiden mit gesteuerter freisetzung und verfahren zu ihrer herstellung
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4638045A (en) * 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4670249A (en) * 1985-04-12 1987-06-02 International Minerals & Chemical Corp. Growth-promoting compositions
DE3523454A1 (de) * 1985-07-01 1987-01-08 Eberhard Prof Dr Nuernberg Formkoerper
IL79681A (en) * 1985-08-12 1991-06-10 Int Minerals & Chem Corp Transition metal complexes of growth hormones and their prolonged release compositions
US4692441A (en) * 1985-08-16 1987-09-08 Merck & Co., Inc. Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities
US4775659A (en) * 1985-08-19 1988-10-04 Eli Lilly And Company Injectable semi-solid formulations
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use

Also Published As

Publication number Publication date
DK251287D0 (da) 1987-05-18
US5939380A (en) 1999-08-17
DE3780862D1 (de) 1992-09-10
EP0246540B1 (de) 1992-08-05
JPS6322012A (ja) 1988-01-29
AU603793B2 (en) 1990-11-29
AU7108987A (en) 1988-09-15
CA1257199A (en) 1989-07-11
US5110595A (en) 1992-05-05
EP0246540A2 (de) 1987-11-25
GR3005395T3 (de) 1993-05-24
DE3780862T2 (de) 1993-01-14
ES2051707T3 (es) 1994-07-01
EP0246540A3 (en) 1988-06-08
DK251287A (da) 1987-11-21

Similar Documents

Publication Publication Date Title
ATE79024T1 (de) Implantate zur abgabe biologisch aktiver makromolekuele.
NZ227788A (en) Peptide having growth hormone regulatory effects, and compositions
DE69435096D1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
DE68926859D1 (de) Natürlicher killerzellen-stimulationsfaktor
NO934592L (no) Materiale for vevsbehandling omfattende fibrin eller fibrinogen, og bionedbrytbart og bioforenligg polymer
NZ227787A (en) Peptides and compositions having growth hormone regulatory effects
DE3851153D1 (de) Genetische modifizierung von endothelialen zellen.
BR8801242A (pt) Processo de preparar uma composicao para fornecer uma quantidade efetiva de uma dose constante de um ingrediente ativo a um animal e a respectiva composicao
DE69113470D1 (de) Intraokulares und intraorbitales Implantat zur kontrollierten Zuführung von Arzneimitteln.
HU9201521D0 (en) Stimulating unit containing nicotine
NL193399B (nl) Injecteerbare implantsamenstelling voor gebruik bij reconstructieve chirurgische behandelingen.
NO891675L (no) Kompositt-materialer for bruk i ortopedi.
TW362020B (en) Release-controlled implantable somatotropin composition
HU9202092D0 (en) An implantate composition containing biologically active protein, peptide or polypeptide
EP0268421A3 (de) Implantatmaterial und Verfahren zur Herstellung desselben
EP0230264A3 (en) Pharmaceutical composition for nasal application, process for its preparation and its use
ATE124863T1 (de) Knochenwachstumsstimulator.
ES2065696T3 (es) Composicion farmaceutica.
EP0390849A4 (en) Methyl cellulose pharmaceutical composition
EP0342416A3 (en) Medicine
BR9006746A (pt) Peptideo fisiologicamente ativo e agente regulador do metabolismo de calcio
RU94021347A (ru) Способ обработки природного апатита и порошок для использования при складировании топливных иррадиационных элементов
Jozefonvicz et al. Polymers and the Living Ambient
CO4230067A1 (es) Composicion cosmetica para el cuidado de la piel
McCann No Halt Expected for(Silicone) Implant Use(Despite Cancer Scare)

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee
RZN Patent revoked