ATE80389T1 - Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator. - Google Patents
Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator.Info
- Publication number
- ATE80389T1 ATE80389T1 AT88121308T AT88121308T ATE80389T1 AT E80389 T1 ATE80389 T1 AT E80389T1 AT 88121308 T AT88121308 T AT 88121308T AT 88121308 T AT88121308 T AT 88121308T AT E80389 T1 ATE80389 T1 AT E80389T1
- Authority
- AT
- Austria
- Prior art keywords
- nitrazole
- derivatives
- fluorine containing
- radiation sensitizers
- sensitizers including
- Prior art date
Links
- 229910052731 fluorine Inorganic materials 0.000 title abstract 3
- 239000011737 fluorine Substances 0.000 title abstract 2
- 239000002534 radiation-sensitizing agent Substances 0.000 title abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000004959 2-nitroimidazoles Chemical class 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000004957 nitroimidazoles Chemical class 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15678787 | 1987-06-24 | ||
| JP63020456A JP2848602B2 (ja) | 1987-06-24 | 1988-01-29 | 新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE80389T1 true ATE80389T1 (de) | 1992-09-15 |
Family
ID=26357414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88121308T ATE80389T1 (de) | 1987-06-24 | 1988-06-10 | Fluorhaltige nitrazol-derivate und diese umfassender strahlungssensibilisator. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0316967B1 (de) |
| JP (1) | JP2848602B2 (de) |
| KR (1) | KR910000663B1 (de) |
| AT (1) | ATE80389T1 (de) |
| DE (1) | DE3874490T2 (de) |
| ES (1) | ES2046281T3 (de) |
| GR (1) | GR3005653T3 (de) |
| IL (1) | IL88665A (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304654A (en) * | 1987-06-10 | 1994-04-19 | Yasunori Nishijima | Fluorine-containing nitroimidazole compounds |
| US5965621A (en) * | 1995-08-17 | 1999-10-12 | Allergan | Methods and compositions for reducing or maintaining body weight in a mammal |
| US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
-
1988
- 1988-01-29 JP JP63020456A patent/JP2848602B2/ja not_active Expired - Lifetime
- 1988-06-09 IL IL8866588A patent/IL88665A/en not_active IP Right Cessation
- 1988-06-10 ES ES198888121308T patent/ES2046281T3/es not_active Expired - Lifetime
- 1988-06-10 EP EP88121308A patent/EP0316967B1/de not_active Expired - Lifetime
- 1988-06-10 AT AT88121308T patent/ATE80389T1/de not_active IP Right Cessation
- 1988-06-10 DE DE8888121308T patent/DE3874490T2/de not_active Expired - Fee Related
-
1989
- 1989-01-20 KR KR1019890000605A patent/KR910000663B1/ko not_active Expired
-
1992
- 1992-09-10 GR GR920401957T patent/GR3005653T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3874490D1 (de) | 1992-10-15 |
| KR910000663B1 (ko) | 1991-01-31 |
| EP0316967B1 (de) | 1992-09-09 |
| IL88665A (en) | 1994-10-07 |
| EP0316967A1 (de) | 1989-05-24 |
| JP2848602B2 (ja) | 1999-01-20 |
| IL88665A0 (en) | 1989-07-31 |
| JPS6479159A (en) | 1989-03-24 |
| ES2046281T3 (es) | 1994-02-01 |
| GR3005653T3 (de) | 1993-06-07 |
| KR900001286A (ko) | 1990-01-31 |
| DE3874490T2 (de) | 1993-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |