ATE81021T1 - Neutralisierung von heparin. - Google Patents

Neutralisierung von heparin.

Info

Publication number
ATE81021T1
ATE81021T1 AT88903515T AT88903515T ATE81021T1 AT E81021 T1 ATE81021 T1 AT E81021T1 AT 88903515 T AT88903515 T AT 88903515T AT 88903515 T AT88903515 T AT 88903515T AT E81021 T1 ATE81021 T1 AT E81021T1
Authority
AT
Austria
Prior art keywords
heparin
blood
heparinase
sulfatase
reductase
Prior art date
Application number
AT88903515T
Other languages
English (en)
Inventor
Robert A Heft
Ann Reese Comfort
Robert S Langer
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE81021T1 publication Critical patent/ATE81021T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A61M1/3675—Deactivation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88903515T 1987-03-10 1988-03-07 Neutralisierung von heparin. ATE81021T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2417587A 1987-03-10 1987-03-10
PCT/US1988/000699 WO1988006899A2 (en) 1987-03-10 1988-03-07 Neutralization of heparin
EP88903515A EP0354916B1 (de) 1987-03-10 1988-03-07 Neutralisierung von heparin

Publications (1)

Publication Number Publication Date
ATE81021T1 true ATE81021T1 (de) 1992-10-15

Family

ID=21819246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88903515T ATE81021T1 (de) 1987-03-10 1988-03-07 Neutralisierung von heparin.

Country Status (6)

Country Link
EP (1) EP0354916B1 (de)
JP (1) JPH02503388A (de)
AT (1) ATE81021T1 (de)
CA (1) CA1315676C (de)
DE (1) DE3875114T2 (de)
WO (1) WO1988006899A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
CA2001720C (en) * 1988-10-31 2001-10-02 Randal A. Goffe Membrane affinity apparatus and purification methods related thereto
US5262325A (en) * 1991-04-04 1993-11-16 Ibex Technologies, Inc. Method for the enzymatic neutralization of heparin
IT1304828B1 (it) * 1998-11-12 2001-04-05 Braun Carex Spa Filtro adsorbitore di eparina e/o endotossine nel plasma e/o nelsangue.
US9095818B2 (en) * 2009-06-15 2015-08-04 Biovec Transfusion, Llc Method of filtering platelets to remove antiplatelet and anticoagulant agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373023A (en) * 1980-10-14 1983-02-08 Massachusetts Institute Of Technology Process for neutralizing heparin

Also Published As

Publication number Publication date
JPH02503388A (ja) 1990-10-18
EP0354916B1 (de) 1992-09-30
CA1315676C (en) 1993-04-06
WO1988006899A3 (en) 1988-12-01
WO1988006899A2 (en) 1988-09-22
DE3875114T2 (de) 1993-03-04
EP0354916A1 (de) 1990-02-21
DE3875114D1 (de) 1992-11-05

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties