ATE81452T1 - Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten. - Google Patents

Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.

Info

Publication number: ATE81452T1
Authority: AT; Austria
Prior art keywords: lower alkyl; thiohydrocarbon; azacycloalkanes; oxo; substituted
Prior art date: 1987-09-30

Application number

AT88908042T

Other languages

English (en)

Inventor

Gevork Minaskanian

James V Peck

Original Assignee

Whitby Research Inc

Gevork Minaskanian

James V Peck

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-30

Filing date

1988-07-25

Publication date

1992-10-15

1988-07-25 Application filed by Whitby Research Inc, Gevork Minaskanian, James V Peck filed Critical Whitby Research Inc

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE81452T1 publication Critical patent/ATE81452T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
150000003976 azacycloalkanes Chemical group 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052736 halogen Chemical group 0.000 abstract 3
239000013543 active substance Substances 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000003386 piperidinyl group Chemical group 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Ink Jet (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

AT88908042T 1987-09-30 1988-07-25 Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten. ATE81452T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/103,445 US4920101A (en)	1987-09-30	1987-09-30	Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
EP88908042A EP0368933B1 (de)	1987-09-30	1988-07-25	Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten
PCT/US1988/002516 WO1989002735A1 (en)	1987-09-30	1988-07-25	Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes

Publications (1)

Publication Number	Publication Date
ATE81452T1 true ATE81452T1 (de)	1992-10-15

Family

ID=22295218

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88908042T ATE81452T1 (de)	1987-09-30	1988-07-25	Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.

Country Status (8)

Country	Link
US (1)	US4920101A (de)
EP (1)	EP0368933B1 (de)
JP (1)	JP2782214B2 (de)
AT (1)	ATE81452T1 (de)
AU (1)	AU615479B2 (de)
CA (1)	CA1337401C (de)
DE (1)	DE3875346T2 (de)
WO (1)	WO1989002735A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879275A (en) *	1987-09-30	1989-11-07	Nelson Research & Development Co.	Penetration enhancers for transdermal delivery of systemic agent
CA1334646C (en) *	1988-04-08	1995-03-07	James Vanolden Peck	Transdermal penetration enhancers
EP0491076A1 (de) *	1990-12-19	1992-06-24	Theratech, Inc.	Penetrationsförderung mittels eines Mehrkomponentensystems aus N-aliphatischen Pyrrolidonen und niederen Alkoholen
US6284754B1 (en) *	1992-01-20	2001-09-04	Schwarz Pharma Ag	Pharmaceutical compositions containing 1-oleylazacycloheptan-2-one as enhancing agent of transport across biological membranes
DE10041478A1 (de) *	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung
US20030027793A1 (en) *	2001-05-08	2003-02-06	Thomas Lauterback	Transdermal treatment of parkinson's disease
US20030026830A1 (en) *	2001-05-08	2003-02-06	Thomas Lauterback	Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US6638981B2 (en) *	2001-08-17	2003-10-28	Epicept Corporation	Topical compositions and methods for treating pain
US20040048779A1 (en) *	2002-05-06	2004-03-11	Erwin Schollmayer	Use of rotigotine for treating the restless leg syndrome
EA009031B1 (ru)	2003-01-24	2007-10-26	Стифел Рисерч Оустрэйлиа Пти Лтд.	Пена на основе фосфата клиндамицина
US20060223786A1 (en) *	2005-04-01	2006-10-05	Smith David J	Transdermal pain control method and device
US20070248657A1 (en) *	2006-04-25	2007-10-25	Smith David J	Multi-compartment transdermal pain control device
EP1987815A1 (de) *	2007-05-04	2008-11-05	Schwarz Pharma Ag	Im Mund-Nasen-Rachenraum verabreichbare pharmazeutische Zusammensetzungen enthaltend Dopaminagonisten zur Vorbeugung und/oder Behandlung von unruhigen Gliedmassen
CN102223791A (zh)	2008-09-27	2011-10-19	塔阿克斯有限公司	用于神经病变治疗的局部用制剂
US20100221313A1 (en) *	2008-12-01	2010-09-02	Innovative Pharmaceuticals, Llc	Transdermal reservoir patch

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3051616A (en) *	1956-03-23	1962-08-28	Bayer Ag	Mothproofing agents
US3085931A (en) *	1960-03-17	1963-04-16	Monsanto Chemicals	Plant virus growth inhibitors
US3157641A (en) *	1960-05-06	1964-11-17	Dow Chemical Co	Preparation of nu, nu'-ethylidene bis (nu-heterocyclic) compounds
DE85661C (de) *	1963-06-12
GB1102521A (en) *	1963-12-10	1968-02-07	British Celanese	N-acyl caprolactams
US3342673A (en) *	1964-09-11	1967-09-19	Mobil Oil Corp	Solvent system for formulating carbamates
US3306910A (en) *	1964-09-14	1967-02-28	Phillips Petroleum Co	Production of thiolactam compounds
US3332938A (en) *	1965-05-11	1967-07-25	Gen Aniline & Film Corp	Alkylated lactams and process of preparation
US3306911A (en) *	1965-08-30	1967-02-28	Phillips Petroleum Co	Method for preparing thiolactams
US3551544A (en) *	1965-12-06	1970-12-29	Tenex Corp	Method of continuously forming an elongated cleated runner of plastic material
US3993073A (en) *	1969-04-01	1976-11-23	Alza Corporation	Novel drug delivery device
US3598122A (en) *	1969-04-01	1971-08-10	Alza Corp	Bandage for administering drugs
US3598123A (en) *	1969-04-01	1971-08-10	Alza Corp	Bandage for administering drugs
US3678156A (en) *	1970-05-15	1972-07-18	Procter & Gamble	Compositions for topical application to animal tissue and method of enhancing penetration thereof
US3954966A (en) *	1970-06-08	1976-05-04	Ceskoslovenska Akademie Ved	Infusion solutions and method of manufacturing same
US3823152A (en) *	1970-07-30	1974-07-09	Fujisawa Pharmaceutical Co	3-substituted-2-piperidinethiones and homologues thereof
US4069307A (en) *	1970-10-01	1978-01-17	Alza Corporation	Drug-delivery device comprising certain polymeric materials for controlled release of drug
GB1343426A (en) *	1971-05-07	1974-01-10	Dow Corning Tld	Acylated lactams
US3731683A (en) *	1971-06-04	1973-05-08	Alza Corp	Bandage for the controlled metering of topical drugs to the skin
US3996934A (en) *	1971-08-09	1976-12-14	Alza Corporation	Medical bandage
US3742951A (en) *	1971-08-09	1973-07-03	Alza Corp	Bandage for controlled release of vasodilators
US3891757A (en) *	1971-11-11	1975-06-24	Alza Corp	Anaesthetic topical and percutaneous administration with selected promoters
US4021224A (en) *	1971-12-09	1977-05-03	Stauffer Chemical Company	Herbicide compositions
BE795384A (fr) *	1972-02-14	1973-08-13	Ici Ltd	Pansements
GB1421743A (en) *	1972-04-18	1976-01-21	Wilkinson Sword Ltd	Ingestible topical and other compositions
GB1421744A (en) *	1972-04-18	1976-01-21	Wilkinson Sword Ltd	Aliphatic n-substituted tertiary amides possessing physiological cooling activity
CH573404A5 (de) *	1972-07-28	1976-03-15	Inventa Ag
US3921636A (en) *	1973-01-15	1975-11-25	Alza Corp	Novel drug delivery device
US3960922A (en) *	1973-11-19	1976-06-01	Stauffer Chemical Company	N-cyanomethyl-N-methyl-3,5-dimethylbenzamide
US3966806A (en) *	1973-11-19	1976-06-29	Stauffer Chemical Company	Insect repellent compounds
US3993072A (en) *	1974-08-28	1976-11-23	Alza Corporation	Microporous drug delivery device
US3972995A (en) *	1975-04-14	1976-08-03	American Home Products Corporation	Dosage form
US4525199A (en) *	1981-05-04	1985-06-25	Nelson Research & Development Co.	Method of improved pest control
US4405616A (en) *	1975-06-19	1983-09-20	Nelson Research & Development Company	Penetration enhancers for transdermal drug delivery of systemic agents
US3989816A (en) *	1975-06-19	1976-11-02	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4562075A (en) *	1982-05-20	1985-12-31	Nelson Research & Development Co.	Penetration enhancers for transdermal drug delivery of systemic agents
BE843140A (fr) *	1975-06-19	1976-10-18		Aazacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients
US3989815A (en) *	1975-06-19	1976-11-02	Nelson Research & Development Company	Novel N-bis-azacyclopentan-2-onyl alkanes
US3991203A (en) *	1975-06-19	1976-11-09	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4316893A (en) *	1975-06-19	1982-02-23	Nelson Research & Development Co.	Vehicle composition containing 1-substituted azacycloalkan-2-ones
NL7609725A (nl) *	1975-09-06	1977-03-08	Hoechst Ag	Alkoxyderivaten van aan de n gesubstitueerde cyclische aminen en werkwijze voor hun be- reiding.
US4077407A (en) *	1975-11-24	1978-03-07	Alza Corporation	Osmotic devices having composite walls
US4031894A (en) *	1975-12-08	1977-06-28	Alza Corporation	Bandage for transdermally administering scopolamine to prevent nausea
US4060084A (en) *	1976-09-07	1977-11-29	Alza Corporation	Method and therapeutic system for providing chemotherapy transdermally
US4201211A (en) *	1977-07-12	1980-05-06	Alza Corporation	Therapeutic system for administering clonidine transdermally
JPS5562012A (en) *	1978-11-06	1980-05-10	Teijin Ltd	Slow-releasing preparation
US4230105A (en) *	1978-11-13	1980-10-28	Merck & Co., Inc.	Transdermal delivery of drugs
US4264594A (en) *	1979-02-02	1981-04-28	The United States Of America As Represented By The Secretary Of Agriculture	Insect repellents
US4284648A (en) *	1979-08-03	1981-08-18	The University Of Kentucky Research Foundation	Nasal administration of propranolol
US4291015A (en) *	1979-08-14	1981-09-22	Key Pharmaceuticals, Inc.	Polymeric diffusion matrix containing a vasodilator
US4444762A (en) *	1980-04-04	1984-04-24	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4415563A (en) *	1980-04-04	1983-11-15	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacyclononan-2-ones
US4424210A (en) *	1980-04-04	1984-01-03	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4423040A (en) *	1980-04-04	1983-12-27	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacyclohexan-2-ones
YU141080A (en) *	1980-05-24	1983-04-30	Sour Pliva	Process for preparing n-chlorocarbonl-lactams
DE3021958A1 (de) *	1980-06-12	1981-12-24	Bayer Ag, 5090 Leverkusen	1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
US4310525A (en) *	1981-01-23	1982-01-12	Nelson Research & Development Company	Method of treatment of inflammation
US4311481A (en) *	1981-01-23	1982-01-19	Nelson Research & Development Company	Method for improved dyeing
US4440777A (en) *	1981-07-07	1984-04-03	Merck & Co., Inc.	Use of eucalyptol for enhancing skin permeation of bio-affecting agents
JPS597163A (ja) *	1982-07-02	1984-01-14	Yamanouchi Pharmaceut Co Ltd	抗動脈硬化剤
JPS5948413A (ja) *	1982-09-14	1984-03-19	Grelan Pharmaceut Co Ltd	クリダナクを含有する消炎鎮痛外用剤
US4537776A (en) *	1983-06-21	1985-08-27	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4552872A (en) *	1983-06-21	1985-11-12	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions containing corticosteroids
US4557934A (en) *	1983-06-21	1985-12-10	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4605670A (en) *	1984-02-01	1986-08-12	Nitto Electric Industrial Co., Ltd.	Method for percutaneously administering metoclopramide
US4743588A (en) *	1984-06-13	1988-05-10	Allergan Pharmaceuticals, Inc.	Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents
US4621143A (en) *	1984-06-27	1986-11-04	The United States Of America As Represented By The Secretary Of Agriculture	Cockroach repellants
US4626539A (en) *	1984-08-10	1986-12-02	E. I. Dupont De Nemours And Company	Trandermal delivery of opioids
US4620949A (en) *	1985-04-05	1986-11-04	Texaco Inc.	Process for amidocarbonylation of cyclic amides
JPS63502508A (ja) *	1986-01-31	1988-09-22	ホイットビ−・リサ−チ・インコ−ポレ−テッド	１−置換アザシクロアルカンより成る組成物とその用途
US4755535A (en) *	1986-04-23	1988-07-05	Nelson Research & Development Co.	Compositions comprising 1-substituted azacycloalkenes

1987
- 1987-09-30 US US07/103,445 patent/US4920101A/en not_active Expired - Lifetime
1988
- 1988-07-25 WO PCT/US1988/002516 patent/WO1989002735A1/en not_active Ceased
- 1988-07-25 DE DE8888908042T patent/DE3875346T2/de not_active Expired - Fee Related
- 1988-07-25 AT AT88908042T patent/ATE81452T1/de not_active IP Right Cessation
- 1988-07-25 EP EP88908042A patent/EP0368933B1/de not_active Expired - Lifetime
- 1988-07-25 AU AU23216/88A patent/AU615479B2/en not_active Ceased
- 1988-07-25 JP JP63507100A patent/JP2782214B2/ja not_active Expired - Fee Related
- 1988-08-11 CA CA000574417A patent/CA1337401C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE3875346D1 (de)	1992-11-19
EP0368933B1 (de)	1992-10-14
AU2321688A (en)	1989-04-18
WO1989002735A1 (en)	1989-04-06
CA1337401C (en)	1995-10-24
EP0368933A4 (de)	1990-03-28
DE3875346T2 (de)	1993-03-11
US4920101A (en)	1990-04-24
JPH03500287A (ja)	1991-01-24
EP0368933A1 (de)	1990-05-23
JP2782214B2 (ja)	1998-07-30
AU615479B2 (en)	1991-10-03

Legal Events

Date	Code	Title	Description
1993-04-15	UEP	Publication of translation of european patent specification
1996-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE81452T1 (de)	1992-10-15	Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.
FI843765L (fi)	1985-03-27	Kramp motverkande sulfamatderivat.
EP0694558A4 (de)	1996-08-21	Sphingoglycolipid und verwendung davon
PH24415A (en)	1990-06-25	Novel substituted five or six-membered heterocyclic compounds containing the cyanoimino group
ATE74349T1 (de)	1992-04-15	Acrylamid-derivate.
DK0482071T3 (da)	1998-09-07	Nye antivirale midler
IE820467L (en)	1982-09-19	N-heterocyclylmethyl amides
MY100115A (en)	1989-12-18	Nitrogen containing heterocyclic compounds, and their production and use.
DE68908737D1 (de)	1993-10-07	Imidazol-Verbindungen und diese enthaltende Textilbehandlungs-Zusammenstellungen.
ATE123016T1 (de)	1995-06-15	Substituierte naphthalen-verbindungen und diese enthaltende flüssigkristall-zusammensetzungen.
DE3362504D1 (en)	1986-04-17	1-carboxyalkanoylindoline-2-carboxylic-acid esters, their preparation, pharmaceutical compositions containing them, and their therapeutic use
NO922674L (no)	1993-01-13	Spikamycinderivater og anvendelse derav
ATE110102T1 (de)	1994-09-15	Flüssigkristallzusammensetzungen.
DE69203551D1 (de)	1995-08-24	Biologisch abbaubarer Copolyester von 4-Hydroxyprolin und diesen enthaltende pharmazeutische Zusammensetzung.
ES8505231A1 (es)	1985-05-16	Un metodo de preparar nuevos compuestos de benzoilurea
GB9209330D0 (en)	1992-06-17	Chemical compounds
PL336857A1 (en)	2000-07-17	Heterocyclic compounds, method of obtaining them and pharmaceutic composition containing such compounds
DE3662883D1 (en)	1989-05-24	Guanidinobenzoic ester derivative, a process for preparing same and pharmaceutical compositions containing same
CA1273946C (en)	1990-09-11	ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES
FI852693L (fi)	1986-01-10	Envaerda disobutamidderivat.
MY110098A (en)	1998-01-27	Herbicidal composition and weeding method
DE3781986D1 (de)	1992-11-05	Substituierte chinoxaline.
ES8407037A1 (es)	1984-08-16	Un procedimiento para preparar nuevas amidas heterociclicas de acidos fenoxifenoxialcanoicos.
TH13948A (de)	1994-05-20
MY103030A (en)	1993-04-30	Diacyl derivatives of 4-(triakylbenzyl) -piperazinyl compounds