ATE81722T1 - Verfahren zur bestimmung von mimotopen. - Google Patents

Verfahren zur bestimmung von mimotopen.

Info

Publication number
ATE81722T1
ATE81722T1 AT85903646T AT85903646T ATE81722T1 AT E81722 T1 ATE81722 T1 AT E81722T1 AT 85903646 T AT85903646 T AT 85903646T AT 85903646 T AT85903646 T AT 85903646T AT E81722 T1 ATE81722 T1 AT E81722T1
Authority
AT
Austria
Prior art keywords
catamer
preparations
monomers
antibody
composition
Prior art date
Application number
AT85903646T
Other languages
English (en)
Inventor
Hendrik Mario Geysen
Original Assignee
Coselco Mimotopes Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3770684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE81722(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Coselco Mimotopes Pty Ltd filed Critical Coselco Mimotopes Pty Ltd
Application granted granted Critical
Publication of ATE81722T1 publication Critical patent/ATE81722T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Detergent Compositions (AREA)
  • Lubricants (AREA)
  • Saccharide Compounds (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Control Of Eletrric Generators (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Testing Of Optical Devices Or Fibers (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT85903646T 1984-07-24 1985-07-23 Verfahren zur bestimmung von mimotopen. ATE81722T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPG618884 1984-07-24
EP85903646A EP0190205B1 (de) 1984-07-24 1985-07-23 Verfahren zur bestimmung von mimotopen
PCT/AU1985/000165 WO1986000991A1 (en) 1984-07-24 1985-07-23 Method for determining mimotopes

Publications (1)

Publication Number Publication Date
ATE81722T1 true ATE81722T1 (de) 1992-11-15

Family

ID=3770684

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85903646T ATE81722T1 (de) 1984-07-24 1985-07-23 Verfahren zur bestimmung von mimotopen.

Country Status (10)

Country Link
US (2) US5194392A (de)
EP (1) EP0190205B1 (de)
JP (3) JPH07119760B2 (de)
AT (1) ATE81722T1 (de)
CA (1) CA1255586A (de)
DE (1) DE3586772T2 (de)
DK (1) DK164942C (de)
MY (1) MY102885A (de)
NO (1) NO166465C (de)
WO (1) WO1986000991A1 (de)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
EP0241487B1 (de) * 1985-08-28 1998-04-22 PIECZENIK, George Verfahren und mittel zur sortierung und bestimmung biologischer informationen
US5866363A (en) 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US5041381A (en) 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
US6222020B1 (en) * 1987-01-07 2001-04-24 Imperial Cancer Research Technology Limited Antigens derived from the core protein of the human mammary epithelial mucin
JPH07111427B2 (ja) * 1987-10-13 1995-11-29 テラピン テクノロジーズ，インコーポレイテッド 免疫診断薬を製造する方法
US5133866A (en) * 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5300425A (en) * 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5338659A (en) * 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
US5217869A (en) * 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5340474A (en) * 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5266684A (en) * 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5225533A (en) * 1988-05-02 1993-07-06 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
FR2631451A1 (fr) * 1988-05-13 1989-11-17 Inst Nat Sante Rech Med Procede de caracterisation de l'epitope intervenant dans une reaction antigene anticorps, kit ou necessaire pour la mise en oeuvre du procede
US5286789A (en) * 1989-05-26 1994-02-15 Applied Immune Sciences, Inc. Solid phase multiple peptide synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5527681A (en) * 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JP3443119B2 (ja) 1989-08-07 2003-09-02 ペプテック リミテッド 腫瘍壊死因子結合リガンド
US20030225254A1 (en) * 1989-08-07 2003-12-04 Rathjen Deborah Ann Tumour necrosis factor binding ligands
US5959087A (en) * 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
US6075121A (en) * 1990-05-15 2000-06-13 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
US5182366A (en) * 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US6197529B1 (en) 1990-11-21 2001-03-06 Torrey Pines Institute For Molecular Studies Linear substituted oligoalkyleneimine libraries
EP0558671B1 (de) * 1990-11-21 1999-01-27 Iterex Pharmaceuticals Ltd. Partnership Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen
WO1992019767A1 (en) * 1991-04-29 1992-11-12 Terrapin Technologies, Inc. Methods to profile and treat abnormal cells
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5667984A (en) * 1991-05-07 1997-09-16 Oxford Glycosystems Ltd. Sequencing of oligosaccharides
NZ243090A (en) * 1991-06-18 1993-11-25 Lilly Co Eli Method of identifying active peptides and synthesis of peptide mixtures with a known amino acid in the last coupled position
US5698391A (en) * 1991-08-23 1997-12-16 Isis Pharmaceuticals, Inc. Methods for synthetic unrandomization of oligomer fragments
US5747253A (en) * 1991-08-23 1998-05-05 Isis Pharmaceuticals, Inc. Combinatorial oligomer immunoabsorbant screening assay for transcription factors and other biomolecule binding
US5672472A (en) * 1991-08-23 1997-09-30 Isis Pharmaceuticals, Inc. Synthetic unrandomization of oligomer fragments
US6849462B1 (en) 1991-11-22 2005-02-01 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5591646A (en) * 1992-09-02 1997-01-07 Arris Pharmaceutical Method and apparatus for peptide synthesis and screening
US6582902B1 (en) * 1992-09-30 2003-06-24 Jack D. Keene Method for deriving epitopes
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5721099A (en) * 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US6503759B1 (en) 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5565325A (en) * 1992-10-30 1996-10-15 Bristol-Myers Squibb Company Iterative methods for screening peptide libraries
US5807683A (en) * 1992-11-19 1998-09-15 Combichem, Inc. Combinatorial libraries and methods for their use
WO1994020521A1 (de) * 1993-03-12 1994-09-15 Jerini Bio Chemicals Gmbh Verfahren zur synthese und selektionierung von sequenzen aus kovalent verbundenen bausteinen
DE4308410A1 (de) * 1993-03-12 1994-09-15 Schering Ag Verfahren zur Synthese und Selektionierung von Sequenzen aus kovalent verbundenen Bausteinen
US6864048B2 (en) * 1993-04-28 2005-03-08 Affymetrix, Inc. Factorial chemical libraries
IT1270939B (it) * 1993-05-11 1997-05-26 Angeletti P Ist Richerche Bio Procedimento per la preparazione di immunogeni e reagenti diagnostici,e immunogeni e reagenti diagnostici cosi' ottenibili.
US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
US5846731A (en) * 1993-06-17 1998-12-08 Torry Pines Institute For Molecular Studies Peralkylated oligopeptide mixtures
US6008058A (en) * 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US5380668A (en) * 1993-07-06 1995-01-10 University Of Utah Research Foundation Compounds having the antigenicity of hCG
CN1525171A (zh) * 1993-10-01 2004-09-01 ŦԼ�и��ױ��Ǵ�ѧ���� 用标示物编码的多元组合化学库
US5908919A (en) * 1993-10-01 1999-06-01 Terrapin Technologies Urethane mediated, GST specific molecular release systems
CA2173990A1 (en) * 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
WO1995013538A1 (en) * 1993-11-12 1995-05-18 Operon Technologies, Inc. Methods of producing and screening complex chemical libraries
US5492807A (en) * 1993-11-19 1996-02-20 Santi; Daniel V. Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease
US6287787B1 (en) 1993-11-24 2001-09-11 Torrey Pines Institute For Molecular Studies Dimeric oligopeptide mixture sets
WO1995019567A1 (en) * 1994-01-13 1995-07-20 The Trustees Of Columbia University In The City Of New York Synthetic receptors, libraries and uses thereof
US6660276B1 (en) 1994-02-16 2003-12-09 The University Of Virginia Patent Foundation Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor
US6936477B2 (en) * 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US5738996A (en) * 1994-06-15 1998-04-14 Pence, Inc. Combinational library composition and method
US5846841A (en) * 1994-05-20 1998-12-08 Selectide Corporation Motif Libraries
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7625697B2 (en) 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5645996A (en) * 1994-08-24 1997-07-08 Torrey Pines Institute For Molecular Studies Melittin-related polypeptides, mixture sets and libraries thereof
US5582997A (en) * 1994-08-24 1996-12-10 Torrey Pines Institute For Molecular Studies Lysine/leucine polypeptides, mixture sets and libraries thereof
US7597886B2 (en) * 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7820798B2 (en) * 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US5747458A (en) * 1995-06-07 1998-05-05 Chiron Corporation Urokinase receptor ligands
US5958792A (en) * 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
JP2000502897A (ja) * 1995-12-18 2000-03-14 プレーシス ファーマスーティカルズ インコーポレイテッド 標的に結合する化合物を同定する方法
GB9609262D0 (en) * 1996-05-02 1996-07-03 Isis Innovation Peptide library and method
CA2264200A1 (en) 1996-08-16 1998-02-26 Human Genome Sciences, Inc. Human endokine alpha
JP2001500369A (ja) 1996-08-30 2001-01-16 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド インターロイキン―１９
US6183988B1 (en) 1996-10-02 2001-02-06 The General Hospital Corporation Leukocyte-specific protein and gene, and methods of use thereof
DK0939804T4 (da) 1996-10-25 2011-07-18 Human Genome Sciences Inc Neutrokin-alpha
US6025371A (en) * 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US6413724B1 (en) 1996-10-28 2002-07-02 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
CA2271720A1 (en) 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
JP4663824B2 (ja) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド 多重化分子分析装置および方法
ATE442385T1 (de) 1997-09-17 2009-09-15 Human Genome Sciences Inc Interleukin-17 rezeptor-ähnliches protein
ES2303358T3 (es) 1997-11-03 2008-08-01 Human Genome Sciences, Inc. Vegi, un inhibidor de la angiogenesis y el crecimiento tumoral.
JP2001524308A (ja) * 1997-11-21 2001-12-04 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ケモカインα−５
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
WO1999037630A1 (en) 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1093457B8 (de) 1998-03-19 2011-02-02 Human Genome Sciences, Inc. Der gemeinsamen gamma-kette ähnlicher zytokinrezeptor
HUP0104306A2 (hu) * 1998-11-13 2002-03-28 Pepscan Systems B.V. Eljárás mimotóp szekvencia meghatározására
EP2357192A1 (de) 1999-02-26 2011-08-17 Human Genome Sciences, Inc. Menschliches alpha-Endokin und Verfahren zu seiner Verwendung
US6432409B1 (en) * 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US6545032B1 (en) 1999-09-17 2003-04-08 Torrey Pines Institute For Molecular Studies Synthesis of [3,5,7]-H-imidazo[1,5-a] imidazol-2(3H)-one compounds
JP2003516731A (ja) 1999-11-18 2003-05-20 カイロン コーポレイション ヒトｆｇｆ−２１遺伝子および遺伝子発現産物
EP1261638A2 (de) 2000-03-08 2002-12-04 Chiron Corporation Humanes fgf-23 gen und genexpressionsprodukte
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
US6759510B1 (en) 2000-06-30 2004-07-06 Becton, Dickinson And Company Peptides for use in culture media
AUPR279101A0 (en) * 2001-01-30 2001-02-22 Cytopia Pty Ltd Protein kinase signalling
US7323327B2 (en) 2001-02-23 2008-01-29 Dsm Ip Assets B.V. Genes encoding novel proteolytic enzymes
DE60236646D1 (de) 2001-04-13 2010-07-22 Human Genome Sciences Inc Anti-VEGF-2 Antikörper
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
AU2003230603A1 (en) * 2002-03-08 2003-09-22 Board Of Regents, The University Of Texas System Controlled modulation of amino acid side chain length of peptide antigens
PL373887A1 (en) 2002-05-21 2005-09-19 Dsm Ip Assets B.V. Novel phospholipases and uses thereof
AR042417A1 (es) 2002-08-19 2005-06-22 Dsm Ip Assets Bv Lipasas y usos de las mismas
MXPA05002219A (es) 2002-08-28 2005-07-05 Immunex Corp Composiciones y metodos para tratar una enfermedad cardiovascular.
CA2499123A1 (en) 2002-09-17 2004-04-15 Antigen Express, Inc. Ii-key/antigenic epitope hybrid peptide vaccines
US7179645B2 (en) * 2002-09-24 2007-02-20 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
US6910785B2 (en) * 2003-01-22 2005-06-28 Cooper Technologies Company Industrial luminaire with prismatic refractor
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
ATE554108T1 (de) 2003-07-25 2012-05-15 Amgen Inc Verfahren bezüglich ldcam und crtam
US7396940B2 (en) 2003-10-23 2008-07-08 Hoffmann-La Roche Inc. Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
CA2574654C (en) 2004-07-22 2014-02-18 Five Prime Therapeutics, Inc. Compositions and methods of use for mgd-csf in disease treatment
US8945573B2 (en) 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
EP2671954B1 (de) 2006-01-20 2018-05-16 Cell Signaling Technology, Inc. Translokation und Mutations-ROS-Kinase bei menschlichem nicht-kleinzelligem Lungenkrebs
EP2447359B1 (de) 2006-04-14 2015-11-04 Cell Signaling Technology, Inc. Gendefekte und mutierte ALK-Kinase in festen menschlichen Tumoren
US20080261226A1 (en) * 2007-02-15 2008-10-23 Rengang Wang Biomarkers of neurodegenerative disease
EP3085367A3 (de) 2007-03-20 2017-01-25 Brandeis University Zusammensetzungen zur diagnose, behandlung und prävention von amyotropher lateralsklerose und assoziierten neurologischen erkrankungen
EP2185688A4 (de) 2007-08-06 2010-08-25 Burnham Inst Medical Research Znf206: ein neuer regulator der selbsterneuerung und pluripotenz embryonaler stammzellen
EP3741851A1 (de) 2007-10-18 2020-11-25 Cell Signaling Technology, Inc. Translokation und mutante ros-kinase in humanem nichtkleinzelligem lungenkarzinom
AU2009262199B2 (en) 2008-06-27 2012-08-09 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
CA2750922A1 (en) * 2009-01-28 2010-08-05 Antigen Express, Inc. Li-key hybrid peptides that modulate the immune response to influenza
JP5979877B2 (ja) 2009-02-12 2016-08-31 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト癌における変異ｒｏｓ発現
NZ750559A (en) 2009-08-27 2023-01-27 Pastoral Greenhouse Gas Res Ltd Complete genome sequence of the methanogen methanobrevibacter ruminantium
US20120101108A1 (en) 2010-08-06 2012-04-26 Cell Signaling Technology, Inc. Anaplastic Lymphoma Kinase In Kidney Cancer
ES2655842T3 (es) 2012-04-18 2018-02-21 Cell Signaling Technology, Inc. EGFR y ROS1 en el cáncer
US10155987B2 (en) 2012-06-12 2018-12-18 Dana-Farber Cancer Institute, Inc. Methods of predicting resistance to JAK inhibitor therapy
WO2019178601A1 (en) 2018-03-16 2019-09-19 Zoetis Services Llc Peptide vaccines against interleukin-31

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949064A (en) * 1973-10-26 1976-04-06 Baxter Laboratories, Inc. Method of detecting antigens or antibodies
US4415491A (en) * 1980-01-14 1983-11-15 The Regents Of The University Of California Synthetic vaccine peptide epitomes of hepatitis B surface antigen
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4591552A (en) * 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
DE3485733D1 (de) * 1983-01-21 1992-06-25 Frederick James Primus Spezifische antigene der cea(karzyno-embryonales-antigen)familie, spezifische antikoerper und verfahren zu ihrer verwendung.
AU573574B2 (en) * 1983-03-08 1988-06-16 Chiron Mimotopes Pty Ltd Immunogenic deteminants of foot and mouth disease virus
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4578217A (en) * 1983-05-12 1986-03-25 New York Blood Center, Inc. Synthetic antigenic peptide derived from hepatitis B surface antigen
US4493795A (en) * 1983-10-17 1985-01-15 Syntex (U.S.A.) Inc. Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
JPH0720884B2 (ja) * 1983-11-07 1995-03-08 ザ・ウイスタ−・インスティテュ−ト 抗イデイオタイプ抗体によって誘発される、腫瘍およびウイルスに対する免疫応答
EP0141783B2 (de) * 1983-11-07 1993-06-16 The Wistar Institute Durch antiidiotype Antikörper induzierte immune Antwort zu Tumoren und Viren
US5266684A (en) * 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures

Also Published As

Publication number Publication date
JPH09183796A (ja) 1997-07-15
DE3586772T2 (de) 1993-03-04
DK136086A (da) 1986-03-24
EP0190205A1 (de) 1986-08-13
MY102885A (en) 1993-03-31
JPH07260783A (ja) 1995-10-13
US5194392A (en) 1993-03-16
DE3586772D1 (de) 1992-11-26
JPH07119760B2 (ja) 1995-12-20
DK136086D0 (da) 1986-03-24
NO861104L (no) 1986-05-16
DK164942C (da) 1993-02-01
JPS61502839A (ja) 1986-12-04
JP2640438B2 (ja) 1997-08-13
JP2796962B2 (ja) 1998-09-10
CA1255586A (en) 1989-06-13
NO166465B (no) 1991-04-15
EP0190205B1 (de) 1992-10-21
DK164942B (da) 1992-09-14
WO1986000991A1 (en) 1986-02-13
EP0190205A4 (de) 1988-01-28
US5998577A (en) 1999-12-07
NO166465C (no) 1991-07-24

Similar Documents

Publication Publication Date Title
NO166465C (no) Fremgangsmaate for bestemmelse av sekvensen av monomerer.
NO865215L (no) Fremgangsmaate for bestemmelse av mimotoper.
AT326818B (de) Verfahren zur bestimmung des vorliegens von antigenen oder ihrer antikorper
DE69331340D1 (de) Verfahren zur Bestimmung von Cyclooxygenase-1-Aktivität
DE3381979D1 (de) Verfahren zur photometrischen bestimmung biologischer agglutinaten.
ATA328286A (de) Zell-linien und verfahren zur herstellung von humanen monoklonalen antikörpern sowie kit und verfahren zur bestimmung der anwesenheit von p.aeruginosa
ES530691A0 (es) Un procedimiento de ensayo para la deteccion de la presencia de un derivado de fibrina reticulado en un fluido corporal de un animal.
ATE10013T1 (de) Verfahren und reagens zur bestimmung von glycerin.
ATE152244T1 (de) Verfahren zur herstellung von imunodiagnose- mitteln
DE3863285D1 (de) Verfahren und reagenz zur bestimmung von persaeuren.
DE3486081D1 (de) Verfahren und testzusammensetzung zur bestimmung von wasserstoffperoxid.
DE3776525D1 (de) Immunochemisches verfahren zur bestimmung von stabilem glykosiliertem haemoglobin.
DE3683165D1 (de) Analytisches element, zusammensetzung, kit und verfahren zur bestimmung von theophyllin durch enzymhemmung.
PT85992A (de) Verfahren zur bestimmung von anti-hiv, mittel dazu und ihre verwendung in diesem verfahren
ATA900186A (de) Verfahren zur bestimmung von antikörpern gegen retroviren sowie testbesteck, retroviren cbl-1 und retroviren cbl-1-antigene hiefür
DE68914252D1 (de) Verfahren zur Bestimmung eines Antigens.
DE69033352D1 (de) Competitives enzym-testverfahren zum nachweis von phosphothioaten
DE3586999D1 (de) Verfahren zur bestimmung von leucinaminopeptidase (lap).
DE3484941D1 (de) Bestimmung von makromolekuelen durch physische entwicklung.
ATE4328T1 (de) Verfahren und reagens zur bestimmung von glycerin.
DE3883808D1 (de) Testsatz, Extraktionsvorrichtung und Verfahren zur Bestimmung von Streptococcus-A-Antigen.
ATE41831T1 (de) Verfahren zur bestimmung von atl-virusantik¯rpern und reagens zu dessen durchfuehrung.
DE3482420D1 (de) Verfahren zur polymerisation von acrylaten oder methacrylaten.
DE3887124D1 (de) VERFAHREN ZUR BESTIMMUNG VON IgM-ANTIKÖRPERN.
DE58907208D1 (de) Verfahren zur Bestimmung von Antikörpern.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee