ATE82954T1 - Tetralin-derivate, verwendbar in der therapie. - Google Patents
Tetralin-derivate, verwendbar in der therapie.Info
- Publication number
- ATE82954T1 ATE82954T1 AT89302533T AT89302533T ATE82954T1 AT E82954 T1 ATE82954 T1 AT E82954T1 AT 89302533 T AT89302533 T AT 89302533T AT 89302533 T AT89302533 T AT 89302533T AT E82954 T1 ATE82954 T1 AT E82954T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- cycloalkyl
- therapy
- derivatives useful
- thiophene
- Prior art date
Links
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical class C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/38—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17313088A | 1988-03-25 | 1988-03-25 | |
| EP89302533A EP0334538B1 (de) | 1988-03-25 | 1989-03-15 | Tetralin-Derivate, verwendbar in der Therapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE82954T1 true ATE82954T1 (de) | 1992-12-15 |
Family
ID=22630664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89302533T ATE82954T1 (de) | 1988-03-25 | 1989-03-15 | Tetralin-derivate, verwendbar in der therapie. |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0407416A1 (de) |
| JP (1) | JP2750187B2 (de) |
| KR (1) | KR970005323B1 (de) |
| AT (1) | ATE82954T1 (de) |
| AU (1) | AU616253B2 (de) |
| CA (1) | CA1331191C (de) |
| DE (1) | DE68903659T2 (de) |
| DK (1) | DK223490D0 (de) |
| ES (1) | ES2053979T3 (de) |
| FI (1) | FI102893B (de) |
| GR (1) | GR3006983T3 (de) |
| NZ (1) | NZ228392A (de) |
| WO (1) | WO1989009050A1 (de) |
| ZA (1) | ZA891903B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA899033B (en) * | 1988-12-01 | 1990-09-26 | Merrell Dow Pharma | Phenoxy and phenylthio,amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections |
| IL109647A (en) * | 1989-02-27 | 1997-04-15 | Lilly Co Eli | Intermediate compounds for ring-substituted 2-amino-1, 2, 3, 4-tetra- hydronaphthalenes and 3-aminochromanes |
| CA2051399C (en) * | 1989-05-31 | 2003-12-30 | Chiu-Hong Lin | Therapeutically useful 2-aminotetralin derivatives |
| US5071875A (en) * | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| SE8904127D0 (sv) * | 1989-12-07 | 1989-12-07 | Astra Ab | New biocyclic amino-substituted compounds |
| FR2659853A1 (fr) * | 1990-03-22 | 1991-09-27 | Midy Spa | Utilisation de derives 2-aminotetraliniques pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale. |
| EP0450238A1 (de) * | 1990-03-30 | 1991-10-09 | Merrell Dow Pharmaceuticals Inc. | Verbindungen für die Behandlung von Migräne |
| US5258379A (en) * | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
| US5096908A (en) * | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
| EP0471515B1 (de) * | 1990-08-15 | 1997-03-05 | Eli Lilly And Company | Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane |
| IT1251877B (it) * | 1991-09-26 | 1995-05-26 | Zambon Spa | Processo per la preparazione di 2-ammino-5,6 dimetossi-tetralina |
| JP3100005B2 (ja) * | 1992-07-28 | 2000-10-16 | 雪印乳業株式会社 | ヒト免疫不全ウィルス感染・増殖抑制剤 |
| WO1995004713A1 (en) * | 1993-08-06 | 1995-02-16 | The Upjohn Company | 2-aminoindans as selective dopamine d3 ligands |
| NZ510988A (en) * | 1998-10-07 | 2005-01-28 | Ortho Mcneil Pharm Inc | N-aralkylaminotetralins useful as ligands for the neuropeptide Y5 receptor |
| AU2001228681A1 (en) * | 2000-01-28 | 2001-08-07 | Melacure Therapeutics Ab | Novel aromatic amines and amides acting on the melanocortin receptors |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| EP1453806B1 (de) | 2001-12-03 | 2007-12-19 | F. Hoffmann-La Roche Ag | Aminotetralinderivate, antagonisten von muscarinrezeptoren |
| PL370765A1 (en) | 2001-12-03 | 2005-05-30 | F.Hoffmann-La Roche Ag | 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists |
| DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
| DE10334188B4 (de) | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1017359A (en) | 1972-07-03 | 1977-09-13 | Frederic P. Hauck | Substituted cyclic polymethylene phenols |
| JPS5124508B2 (de) | 1972-08-14 | 1976-07-24 | ||
| DE2752659A1 (de) | 1976-12-07 | 1978-06-08 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
| CH637363A5 (en) | 1977-11-24 | 1983-07-29 | Sandoz Ag | Process for preparing novel 2-aminotetralins |
| DE2803582A1 (de) | 1978-01-27 | 1979-08-02 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
| ZA825142B (en) | 1981-07-23 | 1983-04-27 | Erba Farmitalia | N-imidazolyl derivatives of 1,2,3,j-tetrahydro-naphthalene, indan and 2-substituted-1-chroman, and process for their preparation |
| DE3479314D1 (en) * | 1984-05-22 | 1989-09-14 | Nelson Res & Dev | Substituted 2-aminotetralins and processes for synthesis |
| IL79323A (en) * | 1985-07-10 | 1990-03-19 | Sanofi Sa | Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them |
| JPH01503777A (ja) * | 1985-10-04 | 1989-12-21 | マツジヨ‐ニ‐ウインスロツプ・ソチエタ・ペル・アチオニ | 縮合脂環式アミノアルコール類 |
| DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
| DE3719924A1 (de) | 1986-12-22 | 1988-06-30 | Bayer Ag | 8-substituierte 2-aminotetraline |
-
1989
- 1989-03-10 CA CA000593340A patent/CA1331191C/en not_active Expired - Fee Related
- 1989-03-13 ZA ZA891903A patent/ZA891903B/xx unknown
- 1989-03-15 WO PCT/US1989/000974 patent/WO1989009050A1/en not_active Ceased
- 1989-03-15 KR KR1019890702193A patent/KR970005323B1/ko not_active Expired - Fee Related
- 1989-03-15 ES ES89302533T patent/ES2053979T3/es not_active Expired - Lifetime
- 1989-03-15 AU AU32846/89A patent/AU616253B2/en not_active Ceased
- 1989-03-15 AT AT89302533T patent/ATE82954T1/de not_active IP Right Cessation
- 1989-03-15 DE DE8989302533T patent/DE68903659T2/de not_active Expired - Fee Related
- 1989-03-15 EP EP89903628A patent/EP0407416A1/de active Pending
- 1989-03-15 EP EP89302533A patent/EP0334538B1/de not_active Expired - Lifetime
- 1989-03-15 JP JP1503368A patent/JP2750187B2/ja not_active Expired - Lifetime
- 1989-03-20 NZ NZ228392A patent/NZ228392A/xx unknown
-
1990
- 1990-09-17 DK DK223490A patent/DK223490D0/da unknown
- 1990-09-24 FI FI904696A patent/FI102893B/fi not_active IP Right Cessation
-
1993
- 1993-02-04 GR GR930400233T patent/GR3006983T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0407416A1 (de) | 1991-01-16 |
| JP2750187B2 (ja) | 1998-05-13 |
| JPH03503411A (ja) | 1991-08-01 |
| KR900700088A (ko) | 1990-08-11 |
| KR970005323B1 (ko) | 1997-04-15 |
| GR3006983T3 (de) | 1993-06-30 |
| DE68903659D1 (de) | 1993-01-14 |
| ZA891903B (en) | 1989-11-29 |
| FI904696A0 (fi) | 1990-09-24 |
| EP0334538B1 (de) | 1992-12-02 |
| CA1331191C (en) | 1994-08-02 |
| FI102893B1 (fi) | 1999-03-15 |
| AU616253B2 (en) | 1991-10-24 |
| DK223490A (da) | 1990-09-17 |
| NZ228392A (en) | 1991-11-26 |
| FI102893B (fi) | 1999-03-15 |
| AU3284689A (en) | 1989-10-16 |
| EP0334538A1 (de) | 1989-09-27 |
| WO1989009050A1 (en) | 1989-10-05 |
| DK223490D0 (da) | 1990-09-17 |
| ES2053979T3 (es) | 1994-08-01 |
| DE68903659T2 (de) | 1993-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE68903659D1 (de) | Tetralin-derivate, verwendbar in der therapie. | |
| BG102792A (bg) | Производни на заместени 4-хидроксифенилалканоилови киселини с агонистична активност към рраr-гама | |
| ES2062009T4 (es) | Agentes antifungicos derivados de triazol | |
| ES2062974T3 (es) | Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos. | |
| FI943561A0 (fi) | Uudet ainekoostumukset | |
| ATE132134T1 (de) | Benzamide | |
| FI923514A0 (fi) | Herbicider. | |
| DE69124868D1 (de) | Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane | |
| EP0632031A4 (de) | ||
| ZA902633B (en) | New sulphonamides derived from benzo-cyclic or benzo heterocyclic acids,their preparation and their application in therapy | |
| HUP0203787A2 (hu) | Hidroxi-acetil-piperazinnal szubsztituált oxazolidinon-benzoesav-észterek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| BR8907772A (pt) | Composto,processo de controle de vegetacao indesejavel e composicao herbicida | |
| DK0452390T3 (da) | Halogensubstituerede aminotetraliner | |
| ATE118770T1 (de) | Thiazolidinone und oxazolidenonederivate, ihre herstellung und ihre anwendung als vasodilatatoren. | |
| SE7904358L (sv) | Nya derivat av 4-amino-2-piperidinokinazolin | |
| DK0458363T3 (da) | Fluorerede bis(hydroxymethyl)cyclobutylpuriner og -pyrimidiner | |
| AR245699A1 (es) | Compuestos derivados de n'-alquil-n,n'-diacilhidrazinas insecticidamente activos y composicion que los comprende. | |
| DE69020661D1 (de) | Azabicyclische Derivate mit Affinität am Muskarine Rezeptor. | |
| DK498889D0 (da) | Substituerede aromatiske forbindelser med virkning paa centralnervesystemet | |
| DE69224613D1 (de) | Peptide, Herstellung und deren Verwendung | |
| FI853685A0 (fi) | Nya n-alk(en)yl-n-(o,o-disubstituerade -tiofosforyl)-n'n'-disubstituerade glycinamider, foerfarande foer framstaellning av dessa samt kvalstergifter, insektgifter och svampgifter vilka innehaoller dessa som aktiv bestaondsdel. | |
| HUP9700954A2 (hu) | Szubsztituált 1-naftoil-guanidin-származékok, előállításuk, valamint az e vegyületeket tartalmazó gyógyszerkészítmények | |
| FI852204L (fi) | 3-nitrodihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |