ATE83660T1 - Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung. - Google Patents

Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung.

Info

Publication number
ATE83660T1
ATE83660T1 AT90201353T AT90201353T ATE83660T1 AT E83660 T1 ATE83660 T1 AT E83660T1 AT 90201353 T AT90201353 T AT 90201353T AT 90201353 T AT90201353 T AT 90201353T AT E83660 T1 ATE83660 T1 AT E83660T1
Authority
AT
Austria
Prior art keywords
production
refrigerator temperature
solution stable
aqueous
folinate solution
Prior art date
Application number
AT90201353T
Other languages
English (en)
Inventor
Alfred James Nijker
Johanna Maria Pieterne Vermeer
Original Assignee
Pharmachemie Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv
Application granted granted Critical
Publication of ATE83660T1 publication Critical patent/ATE83660T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT90201353T 1989-06-06 1990-05-28 Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung. ATE83660T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8901432A NL8901432A (nl) 1989-06-06 1989-06-06 Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.

Publications (1)

Publication Number Publication Date
ATE83660T1 true ATE83660T1 (de) 1993-01-15

Family

ID=19854784

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90201353T ATE83660T1 (de) 1989-06-06 1990-05-28 Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung.

Country Status (13)

Country Link
US (1) US5177076A (de)
EP (1) EP0401895B1 (de)
JP (1) JP2945718B2 (de)
AT (1) ATE83660T1 (de)
AU (1) AU626421B2 (de)
CA (1) CA2018230C (de)
DE (1) DE69000645T2 (de)
DK (1) DK0401895T3 (de)
ES (1) ES2036396T3 (de)
FI (1) FI96275C (de)
IL (1) IL92370A0 (de)
NL (1) NL8901432A (de)
NO (1) NO176389C (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH684644A5 (de) 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
CN1047076C (zh) * 1993-04-28 1999-12-08 吉富制药株式会社 稳定的注射剂及注射剂的稳定方法
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US5660835A (en) * 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
WO2002085297A2 (en) * 2001-04-24 2002-10-31 East Carolina University Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease
US20050070487A1 (en) * 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
US7405207B2 (en) * 2002-06-17 2008-07-29 Epigenesis Pharmaceuticals, Inc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
EP1553954A4 (de) * 2002-06-17 2009-12-23 Epigenesis Pharmaceuticals Llc Dihydrat-dehydroepiandrosteron und verfahren zur behandlung von asthma oder chronisch obstruktiver lungenerkrankung mit zusammensetzungen daraus
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050026880A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090285899A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026848A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
KR20060051135A (ko) * 2004-09-15 2006-05-19 니프로 가부시키가이샤 안정화된 주사용 수용액 제재
US9713616B2 (en) 2012-08-06 2017-07-25 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising L-leucovorin
CN120617167B (zh) * 2025-07-25 2026-03-24 连云港众维生物医药有限公司 提高亚叶酸钙注射液稳定性非最终灭菌生产工艺及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
US4344940A (en) * 1981-11-30 1982-08-17 E. R. Squibb & Sons, Inc. Steroid formulation containing dipotassium EDTA
US4436738A (en) * 1982-03-15 1984-03-13 Mead Johnson & Company Stabilized estradiol cream composition

Also Published As

Publication number Publication date
NO902487L (no) 1990-12-07
JP2945718B2 (ja) 1999-09-06
EP0401895B1 (de) 1992-12-23
ES2036396T3 (es) 1993-05-16
US5177076A (en) 1993-01-05
AU626421B2 (en) 1992-07-30
FI96275B (fi) 1996-02-29
DK0401895T3 (da) 1993-04-13
AU5629790A (en) 1990-12-13
FI96275C (fi) 1996-06-10
FI902712A0 (fi) 1990-05-31
CA2018230C (en) 1996-04-16
CA2018230A1 (en) 1990-12-06
DE69000645T2 (de) 1993-05-13
JPH0356418A (ja) 1991-03-12
EP0401895A1 (de) 1990-12-12
DE69000645D1 (de) 1993-02-04
NO176389B (no) 1994-12-19
NO902487D0 (no) 1990-06-05
IL92370A0 (en) 1990-07-26
NL8901432A (nl) 1991-01-02
NO176389C (no) 1995-03-29

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Legal Events

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EELA Cancelled due to lapse of time