ATE84313T1 - Substratunterstuetzte katalyse. - Google Patents
Substratunterstuetzte katalyse.Info
- Publication number
- ATE84313T1 ATE84313T1 AT88903692T AT88903692T ATE84313T1 AT E84313 T1 ATE84313 T1 AT E84313T1 AT 88903692 T AT88903692 T AT 88903692T AT 88903692 T AT88903692 T AT 88903692T AT E84313 T1 ATE84313 T1 AT E84313T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme
- catalytic
- substrate
- catalysis
- mutant
- Prior art date
Links
- 238000006555 catalytic reaction Methods 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 5
- 108090000790 Enzymes Proteins 0.000 abstract 5
- 230000003197 catalytic effect Effects 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3408587A | 1987-04-02 | 1987-04-02 | |
| PCT/US1988/001078 WO1988007578A1 (en) | 1987-04-02 | 1988-03-30 | Substrate assisted catalysis |
| EP88903692A EP0308499B1 (de) | 1987-04-02 | 1988-03-30 | Substratunterstützte katalyse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE84313T1 true ATE84313T1 (de) | 1993-01-15 |
Family
ID=21874212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88903692T ATE84313T1 (de) | 1987-04-02 | 1988-03-30 | Substratunterstuetzte katalyse. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0308499B1 (de) |
| AT (1) | ATE84313T1 (de) |
| DE (1) | DE3877300T2 (de) |
| WO (1) | WO1988007578A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| WO1990004788A1 (en) * | 1988-10-28 | 1990-05-03 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| US5688666A (en) * | 1988-10-28 | 1997-11-18 | Genentech, Inc. | Growth hormone variants with altered binding properties |
| US5665587A (en) | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| US5340735A (en) * | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
| AU654563B2 (en) * | 1991-07-24 | 1994-11-10 | Imperial Chemical Industries Plc | Proteins |
| ATE455171T1 (de) * | 1995-09-21 | 2010-01-15 | Genentech Inc | Varianten des menschlichen wachstumshormons |
| CA2238296C (en) | 1995-12-12 | 2008-07-22 | Takara Shuzo Co., Ltd. | Ultrathermostable protease genes |
| KR100591553B1 (ko) | 1996-11-04 | 2006-06-19 | 노보자임스 에이/에스 | 섭틸라제 변종과 조성물 |
| US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
| WO2001007578A2 (en) | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
| MXPA02000842A (es) | 1999-07-22 | 2002-07-30 | Procter & Gamble | Conjugados de proteasa que tienen sitios de corte protegidos estericamente. |
| JP2003505067A (ja) | 1999-07-22 | 2003-02-12 | ザ、プロクター、エンド、ギャンブル、カンパニー | 特定のエピトープ領域にアミノ酸欠失及び置換を有するサブチリシンプロテアーゼの変異体 |
| US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
| CN108060170B (zh) * | 2017-12-29 | 2020-05-15 | 江南大学 | 一种新型金属离子耐受性角蛋白酶及其应用 |
-
1988
- 1988-03-30 DE DE8888903692T patent/DE3877300T2/de not_active Expired - Lifetime
- 1988-03-30 AT AT88903692T patent/ATE84313T1/de not_active IP Right Cessation
- 1988-03-30 EP EP88903692A patent/EP0308499B1/de not_active Expired - Lifetime
- 1988-03-30 WO PCT/US1988/001078 patent/WO1988007578A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0308499B1 (de) | 1993-01-07 |
| WO1988007578A1 (en) | 1988-10-06 |
| EP0308499A1 (de) | 1989-03-29 |
| DE3877300T2 (de) | 1993-06-03 |
| DE3877300D1 (de) | 1993-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |