ATE84545T1 - Derivate des alpha-anp und ihre herstellung. - Google Patents

Derivate des alpha-anp und ihre herstellung.

Info

Publication number: ATE84545T1
Authority: AT; Austria
Prior art keywords: alpha; gly; arg; hydrogen; production
Prior art date: 1987-09-29

Application number

AT87308586T

Other languages

German (de)

English (en)

Inventor

Masahiko Fujino

Mitsuhiro Wakimasu

Kohei Nishikawa

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-29

Filing date

1987-09-29

Publication date

1993-01-15

1987-09-29 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1993-01-15 Application granted granted Critical

1993-01-15 Publication of ATE84545T1 publication Critical patent/ATE84545T1/de

Links

125000003275 alpha amino acid group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
230000007935 neutral effect Effects 0.000 abstract 2
229940126585 therapeutic drug Drugs 0.000 abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical group OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
125000002038 D-arginyl group Chemical group N[C@@H](C(=O)*)CCCNC(=N)N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000001953 Hypotension Diseases 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical group OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
208000021822 hypotensive Diseases 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
229940124280 l-arginine Drugs 0.000 abstract 1
230000001452 natriuretic effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
- C07K14/582—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin at least 1 amino acid in D-form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)

AT87308586T 1987-09-29 1987-09-29 Derivate des alpha-anp und ihre herstellung. ATE84545T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP87308586A EP0269220B1 (en)	1986-09-29	1987-09-29	Derivatives of alpha-hanp and their production
JP5231429A JPH0726436A (ja)	1993-09-17	1993-09-17	人工芝用パイルおよびその製造方法

Publications (1)

Publication Number	Publication Date
ATE84545T1 true ATE84545T1 (de)	1993-01-15

Family

ID=16923426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87308586T ATE84545T1 (de)	1987-09-29	1987-09-29	Derivate des alpha-anp und ihre herstellung.

Country Status (6)

Country	Link
US (1)	US5159061A (ja)
EP (1)	EP0269220B1 (ja)
JP (2)	JP2508755B2 (ja)
AT (1)	ATE84545T1 (ja)
CA (1)	CA1339678C (ja)
DE (1)	DE3783579T2 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0246795A3 (en) *	1986-05-20	1990-04-04	Advanced Peptide Development Limited	Synthetic natriuretic peptides
US5565606A (en) *	1986-10-21	1996-10-15	Hoechst Aktiengesellschaft	Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
DE3723551A1 (de) *	1987-07-16	1989-01-26	Hoechst Ag	Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
AU2927889A (en) *	1987-12-24	1989-07-19	California Biotechnology, Inc.	Linear analogs of atrial natriuretic peptides
US5047397A (en) *	1988-08-26	1991-09-10	California Biotechnology Inc.	Linear analogs of atrial natriuretic peptides
JP2873586B2 (ja) *	1988-07-15	1999-03-24	武田薬品工業株式会社	抗体およびこれを用いる免疫化学的測定方法
WO1990005103A1 (en) *	1988-11-03	1990-05-17	Prime Technology	A sheet feeding apparatus
JPH06256387A (ja) *	1991-06-14	1994-09-13	Suetsuna Yoko	新規なペプチド、その製法およびそれを有効成分とする血圧降下剤
US5665704A (en) *	1993-11-12	1997-09-09	Genentech, Inc.	Receptor specific atrial natriuretic peptides
US6525022B1 (en)	1993-11-12	2003-02-25	Genentech, Inc.	Receptor specific atrial natriuretic peptides
US5846932A (en) *	1993-11-12	1998-12-08	Genentech, Inc.	Receptor specific atrial natriuretic peptides
US8580746B2 (en) *	2006-03-30	2013-11-12	Palatin Technologies, Inc.	Amide linkage cyclic natriuretic peptide constructs
EP2001518B1 (en) *	2006-03-30	2013-07-10	Palatin Technologies, Inc.	Cyclic natriuretic peptide constructs
US7795221B2 (en) *	2006-03-30	2010-09-14	Palatin Technologies, Inc.	Linear natriuretic peptide constructs

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5178029A (ja) *	1974-12-27	1976-07-07	Mitsubishi Rayon Co
JPS5421477A (en) *	1977-07-20	1979-02-17	Nitto Boseki Co Ltd	Rotating disc of reinforced plastic
JPS5841955A (ja) *	1981-08-31	1983-03-11	関島　唯雄	水引用巻着フイルムの製造方法
AU572173B2 (en) *	1983-08-29	1988-05-05	Institut De Recherches Cliniques De Montreal	Natriuretic factors
US4508712A (en) *	1984-01-10	1985-04-02	Washington University	Atrial peptide
DE3588006T2 (de) *	1984-04-19	1995-08-10	Scios Nova Inc	Atrielle natriumuretische/gefässerweiterende polypeptide.
JPS60259646A (ja) *	1984-06-01	1985-12-21	帝人株式会社	嵩高混繊糸
NZ212291A (en) *	1984-06-08	1991-10-25	Suntory Ltd	Peptide from human atrium cordis having diuretic action, dna coding therefor and pharmaceutical compositions thereof
JPS617260U (ja) *	1984-06-19	1986-01-17	国産電機株式会社	電動機
JPS61286400A (ja) *	1985-06-14	1986-12-16	Ajinomoto Co Inc	新規ペプチド
US4670540A (en) *	1984-08-29	1987-06-02	Ajinomoto Co., Inc.	Novel peptide
JPS61233698A (ja) *	1985-04-09	1986-10-17	Ajinomoto Co Inc	新規ペプチド
JPH0672157B2 (ja) *	1984-08-29	1994-09-14	味の素株式会社	新規ペプチド
DE3443257A1 (de) *	1984-11-28	1986-05-28	Bissendorf Peptide GmbH, 3002 Wedemark	Mittel enthaltend vollsynthetisches alpha-humanes atriales natriuretisches peptid (alpha-hanap)
JPS61161299A (ja) *	1985-01-04	1986-07-21	メルク　エンド　カムパニ−　インコ−ポレ−テツド	心房ペプチド
JPS61280400A (ja) *	1985-06-04	1986-12-10	三菱電機株式会社	アクテイブ近接信管
US4757048A (en) *	1985-11-05	1988-07-12	Biotechnology Research Associates J.V.	Synthetic analogs of atrial natriuretic peptides
IE862891L (en) *	1985-11-05	1987-05-05	Behringwerke Ag	Analogs of atrial natriuretic peptides
DE3614833A1 (de) *	1986-01-16	1987-07-23	Hoechst Ag	Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
EP0232078A3 (en) *	1986-01-31	1990-03-14	Merck & Co. Inc.	Peptides having anf activity
EP0246795A3 (en) *	1986-05-20	1990-04-04	Advanced Peptide Development Limited	Synthetic natriuretic peptides

1987
- 1987-09-25 US US07/101,199 patent/US5159061A/en not_active Expired - Fee Related
- 1987-09-25 CA CA000547893A patent/CA1339678C/en not_active Expired - Fee Related
- 1987-09-28 JP JP62244885A patent/JP2508755B2/ja not_active Expired - Fee Related
- 1987-09-29 EP EP87308586A patent/EP0269220B1/en not_active Expired - Lifetime
- 1987-09-29 AT AT87308586T patent/ATE84545T1/de not_active IP Right Cessation
- 1987-09-29 DE DE8787308586T patent/DE3783579T2/de not_active Expired - Fee Related
1993
- 1993-09-17 JP JP5231429A patent/JPH0726436A/ja active Pending

Also Published As

Publication number	Publication date
JP2508755B2 (ja)	1996-06-19
DE3783579T2 (de)	1993-05-13
US5159061A (en)	1992-10-27
DE3783579D1 (de)	1993-02-25
JPS63179891A (ja)	1988-07-23
EP0269220A3 (en)	1990-05-23
EP0269220B1 (en)	1993-01-13
JPH0726436A (ja)	1995-01-27
EP0269220A2 (en)	1988-06-01
CA1339678C (en)	1998-02-17

Legal Events

Date	Code	Title	Description
1993-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE84545T1 (de)	1993-01-15	Derivate des alpha-anp und ihre herstellung.
ATE234287T1 (de)	2003-03-15	Anregende aminosäuren antagonisten
US3313813A (en)	1967-04-11	(3-amino-5, 6-disubstituted-pyrazinoyl) guanidines
LU90562I2 (fr)	2000-06-05	Acides imidazoalc-noiques
DE69817393D1 (de)	2003-09-25	Neue heterozyklische verbindungen
US3487082A (en)	1969-12-30	2,4 - diamino - 6 - halopteridines and processes for their preparation
ATE3283T1 (de)	1983-05-15	Somatostatin-analoge peptide, ihre herstellung und verwendung, sie enthaltende pharmazeutische praeparate und deren herstellung.
DE68924804D1 (de)	1995-12-21	Polypeptid mit sich wiederholenden zelladhäsiven Hauptsequenzen.
NO882239D0 (no)	1988-05-20	Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
NO882238D0 (no)	1988-05-20	Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
US5330978B1 (en)	1996-06-18	Phosphonic acid derivatives and use thereof
CA1051802A (en)	1979-04-03	Amino acid derivatives and a process for the preparation thereof
DE3770680D1 (de)	1991-07-18	Spergualinaehnliche verbindungen und ihr herstellungsverfahren.
NO852514L (no)	1985-12-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-alkyltio-2-piperazino-pyrimido (5,4-d) pyrimidin-derivater.
ZA925093B (en)	1993-04-28	6-oxo-azepinoindol compounds as well as a process and intermediate products for the production thereof,and drugs that contain these compounds
ES8606847A1 (es)	1986-05-16	Procedimiento para la preparacion de derivados de dialquila-mino-etilanilina antihipertensos
IT1211792B (it)	1989-11-03	O-alcanoil derivati dell'acido 3ammino-2-idrossipropansolfonico adattivita'anticonvulsivante e loro composizioni farmaceutiche per il trattamento terapeutico dell'epilessia
ATE67506T1 (de)	1991-10-15	Pristinamycin-verfahren.
US5741781A (en)	1998-04-21	Mercaptoalkanoyldipeptide compounds
EP0195433B1 (en)	1989-02-08	Amide derivatives processes for preparing them and use thereof