ATE853T1 - NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE. - Google Patents
NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE.Info
- Publication number
- ATE853T1 ATE853T1 AT79101590T AT79101590T ATE853T1 AT E853 T1 ATE853 T1 AT E853T1 AT 79101590 T AT79101590 T AT 79101590T AT 79101590 T AT79101590 T AT 79101590T AT E853 T1 ATE853 T1 AT E853T1
- Authority
- AT
- Austria
- Prior art keywords
- acid addition
- addition salts
- imidazoles
- manufacture
- processes
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 159000000027 imidazo[1,2-a]imidazoles Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000000059 bradycardiac effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Resins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the formula <IMAGE> wherein R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, methoxy or trifluoromethyl, provided that one of them is other than hydrogen; and R4 and R5, which may be identical to or different from each other, are each hydrogen or methyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782827617 DE2827617A1 (en) | 1978-06-23 | 1978-06-23 | NEW IMIDAZO ANGLE CLAMP ON 1,2- ALPHA ANGLE CLAMP ON IMIDAZOLE, THEIR ACID ADDITIONAL SALTS, THE MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF |
| EP79101590A EP0006451B1 (en) | 1978-06-23 | 1979-05-23 | Imidazo (1,2-a) imidazoles, their acid addition salts, medicaments containing them and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE853T1 true ATE853T1 (en) | 1982-04-15 |
Family
ID=6042588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79101590T ATE853T1 (en) | 1978-06-23 | 1979-05-23 | NEW IMIDAZO(1,2-A)IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICINES CONTAINING THEM AND PROCESSES FOR THEIR MANUFACTURE. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4210659A (en) |
| EP (1) | EP0006451B1 (en) |
| JP (1) | JPS554392A (en) |
| AT (1) | ATE853T1 (en) |
| AU (1) | AU519287B2 (en) |
| CA (1) | CA1115280A (en) |
| DE (2) | DE2827617A1 (en) |
| DK (1) | DK146389C (en) |
| ES (4) | ES481799A1 (en) |
| FI (1) | FI65068C (en) |
| IE (1) | IE48355B1 (en) |
| IL (1) | IL57627A (en) |
| MX (1) | MX5687E (en) |
| NO (1) | NO151465C (en) |
| NZ (1) | NZ190801A (en) |
| PT (1) | PT69804A (en) |
| YU (1) | YU42307B (en) |
| ZA (1) | ZA793108B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3042636A1 (en) * | 1980-11-12 | 1982-06-16 | C.H. Boehringer Sohn, 6507 Ingelheim | NEW 7- (2,6-DIBROM-4-METHYLPHENYL) -2,3-DIHYDRO-IMIDAZO (1,2-A) IMIDAZOLES, THEIR ACID ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF |
| DE3124701A1 (en) * | 1981-06-24 | 1983-01-13 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW L-SUBSTITUTED IMIDAZO (1,2-A) IMIDAZOLES, THEIR ACID ADDITION SALTS, THE MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF |
| JP2004505978A (en) * | 2000-08-09 | 2004-02-26 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Synthesis of (R) -3- (4-bromobenzyl) -1- (3,5-dichlorophenyl) -5-iodo-3-methyl-1-H-imidazo [1,2-a] imidazol-2-one |
| KR20040034594A (en) * | 2001-01-26 | 2004-04-28 | 브리스톨-마이어스스퀴브컴파니 | Imidazolyl Derivatives as Corticotropin Releasing Factor Inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2393826A (en) * | 1944-02-28 | 1946-01-29 | Commercial Solvents Corp | 1,3,7-triazabicyclo [3.3.0] octanes |
| DE2109524A1 (en) * | 1971-03-01 | 1972-09-07 | CH. Boehringer Sohn, 6507 Ingelheim | 2,3-dihydr-dioxo-imidazo (1,2-a) imidazoles or pyrimidines - with hypotensive and neuroleptic activity |
| DE2118261A1 (en) * | 1971-04-15 | 1972-11-02 | C.H. Boehringer Sohn, 6507 Ingelheim | New N-containing bicycles, their acid addition salts and processes for their production |
| US3865836A (en) * | 1972-12-08 | 1975-02-11 | Janssen Pharmaceutica Nv | Bicyclic imidazoles |
-
1978
- 1978-06-23 DE DE19782827617 patent/DE2827617A1/en not_active Withdrawn
-
1979
- 1979-05-23 DE DE7979101590T patent/DE2962503D1/en not_active Expired
- 1979-05-23 AT AT79101590T patent/ATE853T1/en not_active IP Right Cessation
- 1979-05-23 EP EP79101590A patent/EP0006451B1/en not_active Expired
- 1979-06-21 YU YU1471/79A patent/YU42307B/en unknown
- 1979-06-21 MX MX798104U patent/MX5687E/en unknown
- 1979-06-21 AU AU48275/79A patent/AU519287B2/en not_active Ceased
- 1979-06-21 FI FI791996A patent/FI65068C/en not_active IP Right Cessation
- 1979-06-22 ZA ZA793108A patent/ZA793108B/en unknown
- 1979-06-22 DK DK262879A patent/DK146389C/en active
- 1979-06-22 ES ES481799A patent/ES481799A1/en not_active Expired
- 1979-06-22 PT PT69804A patent/PT69804A/en unknown
- 1979-06-22 CA CA330,436A patent/CA1115280A/en not_active Expired
- 1979-06-22 JP JP7898779A patent/JPS554392A/en active Granted
- 1979-06-22 IL IL57627A patent/IL57627A/en unknown
- 1979-06-22 NZ NZ190801A patent/NZ190801A/en unknown
- 1979-06-22 NO NO792099A patent/NO151465C/en unknown
- 1979-06-27 US US06/052,566 patent/US4210659A/en not_active Expired - Lifetime
- 1979-08-08 IE IE1184/79A patent/IE48355B1/en unknown
- 1979-10-19 ES ES485181A patent/ES485181A1/en not_active Expired
- 1979-10-19 ES ES485180A patent/ES485180A1/en not_active Expired
- 1979-10-19 ES ES485182A patent/ES485182A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES485181A1 (en) | 1980-05-16 |
| EP0006451B1 (en) | 1982-04-14 |
| CA1115280A (en) | 1981-12-29 |
| MX5687E (en) | 1983-12-09 |
| EP0006451A1 (en) | 1980-01-09 |
| JPH0127073B2 (en) | 1989-05-26 |
| NZ190801A (en) | 1984-05-31 |
| IL57627A (en) | 1982-02-28 |
| US4210659A (en) | 1980-07-01 |
| IE791184L (en) | 1979-12-23 |
| IL57627A0 (en) | 1979-10-31 |
| DK146389B (en) | 1983-09-26 |
| NO151465B (en) | 1985-01-02 |
| FI791996A7 (en) | 1979-12-24 |
| FI65068C (en) | 1984-03-12 |
| JPS554392A (en) | 1980-01-12 |
| YU147179A (en) | 1983-06-30 |
| ES485182A1 (en) | 1980-05-16 |
| NO792099L (en) | 1979-12-28 |
| FI65068B (en) | 1983-11-30 |
| YU42307B (en) | 1988-08-31 |
| IE48355B1 (en) | 1984-12-26 |
| DE2827617A1 (en) | 1980-01-10 |
| ZA793108B (en) | 1981-02-25 |
| DE2962503D1 (en) | 1982-05-27 |
| AU4827579A (en) | 1980-01-03 |
| NO151465C (en) | 1985-04-17 |
| DK262879A (en) | 1979-12-24 |
| ES481799A1 (en) | 1980-02-16 |
| ES485180A1 (en) | 1980-05-16 |
| AU519287B2 (en) | 1981-11-19 |
| DK146389C (en) | 1984-03-05 |
| PT69804A (en) | 1979-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |