ATE857T1 - PROCESS FOR THE PRODUCTION OF MEMBRANE PROTEINS FROM NEISSERIA MENINGITIDIS AND VACCINE CONTAINING THEM. - Google Patents

PROCESS FOR THE PRODUCTION OF MEMBRANE PROTEINS FROM NEISSERIA MENINGITIDIS AND VACCINE CONTAINING THEM.

Info

Publication number
ATE857T1
ATE857T1 AT79104391T AT79104391T ATE857T1 AT E857 T1 ATE857 T1 AT E857T1 AT 79104391 T AT79104391 T AT 79104391T AT 79104391 T AT79104391 T AT 79104391T AT E857 T1 ATE857 T1 AT E857T1
Authority
AT
Austria
Prior art keywords
membrane proteins
neisseria meningitidis
production
vaccine containing
optionally
Prior art date
Application number
AT79104391T
Other languages
German (de)
Inventor
Torsten Bertil Dr. Helting
Gerhard Dr. Guthoehrlein
Original Assignee
Behringwerke Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Aktiengesellschaft filed Critical Behringwerke Aktiengesellschaft
Application granted granted Critical
Publication of ATE857T1 publication Critical patent/ATE857T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Process for the isolation of membrane proteins from Neisseria meningitidis which comprises treating the organism with the aqueous solution of a detergent in a concentration of 0.1 to 2% w/v for 15 minutes to 24 hours, allowing the mixture to stand, optionally with agitation, separating the extract from the bacterial residue and optionally carrying out a further purification.
AT79104391T 1978-11-11 1979-11-08 PROCESS FOR THE PRODUCTION OF MEMBRANE PROTEINS FROM NEISSERIA MENINGITIDIS AND VACCINE CONTAINING THEM. ATE857T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782848965 DE2848965A1 (en) 1978-11-11 1978-11-11 METHOD FOR PRODUCING MEMBRANE PROTEINS FROM NEISSERIA MENINGITIDIS AND VACCINE CONTAINING THEM
EP79104391A EP0011243B1 (en) 1978-11-11 1979-11-08 Process for preparing membrane proteins from neisseria meningitidis and vaccines containing them

Publications (1)

Publication Number Publication Date
ATE857T1 true ATE857T1 (en) 1982-04-15

Family

ID=6054405

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79104391T ATE857T1 (en) 1978-11-11 1979-11-08 PROCESS FOR THE PRODUCTION OF MEMBRANE PROTEINS FROM NEISSERIA MENINGITIDIS AND VACCINE CONTAINING THEM.

Country Status (9)

Country Link
EP (1) EP0011243B1 (en)
JP (1) JPS5566519A (en)
AT (1) ATE857T1 (en)
AU (1) AU533386B2 (en)
CA (1) CA1142083A (en)
DE (2) DE2848965A1 (en)
DK (1) DK154841C (en)
ES (1) ES485715A1 (en)
IL (1) IL58673A (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4317811A (en) 1980-09-11 1982-03-02 Merck & Co., Inc. Herpes simplex type 1 subunit vaccine
EP0127681B1 (en) * 1982-12-02 1993-03-03 The Rockefeller University Iga binding protein
US7118757B1 (en) 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
JP5074644B2 (en) 1998-05-29 2012-11-14 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Combination meningococcal B / C vaccine
AU783894B2 (en) 1999-05-19 2005-12-22 Novartis Vaccines And Diagnostics S.R.L. Combination neisserial compositions
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
CA2871789C (en) 2000-01-17 2017-04-04 Novartis Vaccines And Diagnostics S.R.L. Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
GB0103171D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
CA2493124C (en) 2002-08-02 2014-04-29 Glaxosmithkline Biologicals S.A. Vaccine
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
CU23313A1 (en) 2002-11-27 2008-09-25 Inst Finlay Ct De Investigacia MÃ0 / 00 METHOD OF OBTAINING COCLEAR STRUCTURES VACCINAL COMPOSITIONS AND ADJUSTS BASED ON COCLEAR STRUCTURES AND THEIR INTERMEDIARIES
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
JP5173194B2 (en) * 2003-12-23 2013-03-27 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム vaccine
GB0419627D0 (en) 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
DE602007003596D1 (en) 2006-06-12 2010-01-14 Glaxosmithkline Biolog Sa VACCINE
BR122016015627A2 (en) 2007-10-19 2018-10-30 Novartis Ag kit, lyophilized antigen composition and method for preparation of an immunogenic composition
EP2886551A3 (en) 2008-02-21 2015-09-23 Novartis AG Meningococcal fhbp polypeptides
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
WO2010070453A2 (en) 2008-12-17 2010-06-24 Novartis Ag Meningococcal vaccines including hemoglobin receptor
CA2765112A1 (en) 2009-06-10 2010-12-16 Novartis Ag Benzonaphthyridine-containing vaccines
JP2013502918A (en) 2009-08-27 2013-01-31 ノバルティス アーゲー Hybrid polypeptide comprising Neisseria meningitidis fHBP sequence
US8858958B2 (en) 2009-08-27 2014-10-14 Novartis Ag Adjuvant comprising aluminum, oligonucleotide and polycation
JO3257B1 (en) 2009-09-02 2018-09-16 Novartis Ag Vehicles and installations as TLR
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles
US20130022639A1 (en) 2009-09-30 2013-01-24 Novartis Ag Expression of meningococcal fhbp polypeptides
BR112012010531A2 (en) 2009-10-27 2019-09-24 Novartis Ag "fhbp meningococcal modification polypeptides"
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
US9408907B2 (en) 2009-12-15 2016-08-09 Glaxosmithkline Biologicals Sa Homogenous suspension of immunopotentiating compounds and uses thereof
EP2544714A1 (en) 2010-03-10 2013-01-16 GlaxoSmithKline Biologicals S.A. Vaccine composition
WO2012020326A1 (en) 2010-03-18 2012-02-16 Novartis Ag Adjuvanted vaccines for serogroup b meningococcus
AU2011232421B2 (en) 2010-03-23 2015-08-13 Novartis Ag Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc.
BR112013005626B1 (en) 2010-09-10 2022-07-26 Glaxosmithkline Biologicals Sa MENINGOCOCUS, PROCESS FOR THE PREPARATION OF A MENINGOCOCCAL STRAIN, EXTERNAL MEMBRANE VESICLES, IMMUNOGENIC PHARMACEUTICAL COMPOSITION, AND, USE OF A COMPOSITION
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
US20150147356A1 (en) 2011-05-12 2015-05-28 Alan Kimura Antipyretics to enhance tolerability of vesicle-based vaccines
MX2014008988A (en) 2012-02-02 2014-08-27 Novartis Ag Promoters for increased protein expression in meningococcus.
ES2750366T3 (en) 2012-03-08 2020-03-25 Glaxosmithkline Biologicals Sa In vitro potency assay for protein-based meningococcal vaccines
MX357538B (en) 2012-06-14 2018-07-13 Novartis Ag Vaccines for serogroup x meningococcus.
EP2892553A1 (en) 2012-09-06 2015-07-15 Novartis AG Combination vaccines with serogroup b meningococcus and d/t/p
RU2662970C2 (en) 2012-09-18 2018-07-31 Новартис Аг Outer membrane vesicles
CA2940447C (en) 2014-02-28 2023-07-11 Glaxosmithkline Biologicals Sa Modified meningococcal fhbp polypeptides
WO2018042015A1 (en) 2016-09-02 2018-03-08 Glaxosmithkline Biologicals Sa Vaccines for neisseria gonorrhoeae
CN111148531A (en) 2017-09-08 2020-05-12 伊夫罗生物科学公司 bacterial extracellular vesicles
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
US12128094B2 (en) 2018-11-06 2024-10-29 Glaxosmithkline Biologicals Sa Immunogenic compositions comprising OMVs, an acellular pertussis antigen, a tetanus toxoid and a diphtheria toxoid
EP3799884A1 (en) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Immunogenic compositions
GB202115077D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Assay
GB202115072D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Assay
GB202211033D0 (en) 2022-07-28 2022-09-14 Glaxosmithkline Biologicals Sa Purification process

Also Published As

Publication number Publication date
DK154841C (en) 1989-06-05
EP0011243B1 (en) 1982-04-14
JPS5566519A (en) 1980-05-20
AU5268279A (en) 1980-05-15
CA1142083A (en) 1983-03-01
IL58673A0 (en) 1980-02-29
EP0011243A1 (en) 1980-05-28
DK154841B (en) 1988-12-27
DE2848965A1 (en) 1980-05-22
ES485715A1 (en) 1980-05-16
AU533386B2 (en) 1983-11-24
IL58673A (en) 1983-02-23
DE2962526D1 (en) 1982-05-27
JPS6350332B2 (en) 1988-10-07
DK475779A (en) 1980-05-12

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Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time