ATE86257T1 - Verfahren zur herstellung von thiazolobenzimidazolen und zwischenprodukte. - Google Patents

Verfahren zur herstellung von thiazolobenzimidazolen und zwischenprodukte.

Info

Publication number: ATE86257T1
Authority: AT; Austria
Prior art keywords: acid; formula; thiazolobenzimidazole; chem; manufacture
Prior art date: 1987-01-21

Application number

AT88300432T

Other languages

English (en)

Inventor

Robin Gerald Shepherd

Sie-Yearl Chai

Maynard Emanuel Lichty

Arnold Stephen Milowsky

Original Assignee

Wyeth John & Brother Ltd

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-21

Filing date

1988-01-20

Publication date

1993-03-15

1988-01-20 Application filed by Wyeth John & Brother Ltd, American Home Prod filed Critical Wyeth John & Brother Ltd

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE86257T1 publication Critical patent/ATE86257T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
AMLBAOPYPUXEQF-UHFFFAOYSA-N 1-(2,6-difluorophenyl)-1,3-dihydro-[1,3]thiazolo[3,4-a]benzimidazole Chemical compound FC1=CC=CC(F)=C1C1N2C3=CC=CC=C3N=C2CS1 AMLBAOPYPUXEQF-UHFFFAOYSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000002253 acid Substances 0.000 abstract 3
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
IHCQWURUZRYCIU-UHFFFAOYSA-N [1,3]thiazolo[3,2-a]benzimidazole Chemical compound C1=CC=C2N3C=CSC3=NC2=C1 IHCQWURUZRYCIU-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
150000002148 esters Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT88300432T 1987-01-21 1988-01-20 Verfahren zur herstellung von thiazolobenzimidazolen und zwischenprodukte. ATE86257T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878701228A GB8701228D0 (en)	1987-01-21	1987-01-21	Thiazolobenzimidazoles
EP88300432A EP0276133B1 (de)	1987-01-21	1988-01-20	Verfahren zur Herstellung von Thiazolobenzimidazolen und Zwischenprodukte

Publications (1)

Publication Number	Publication Date
ATE86257T1 true ATE86257T1 (de)	1993-03-15

Family

ID=10610964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88300432T ATE86257T1 (de)	1987-01-21	1988-01-20	Verfahren zur herstellung von thiazolobenzimidazolen und zwischenprodukte.

Country Status (16)

Country	Link
US (2)	US4812574A (de)
EP (1)	EP0276133B1 (de)
JP (1)	JP2555397B2 (de)
KR (1)	KR960004536B1 (de)
AT (1)	ATE86257T1 (de)
AU (1)	AU602045B2 (de)
CA (1)	CA1327042C (de)
DE (1)	DE3878700T2 (de)
DK (1)	DK169819B1 (de)
ES (1)	ES2045098T3 (de)
GB (2)	GB8701228D0 (de)
HU (1)	HU201081B (de)
IE (1)	IE61348B1 (de)
IL (1)	IL85135A (de)
PT (1)	PT86567B (de)
ZA (1)	ZA88378B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1243362B (it) *	1990-07-25	1994-06-10	Pietro Monforte	Sintesi di attivita' anti-hiv di 1h, 3h-tiazolo 3,4-a benzimidazoli 1-sostituiti
WO2010077295A1 (en) *	2008-12-09	2010-07-08	King Faisal Specialist Hospital & Research Centre	Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
CN111116613B (zh) *	2019-12-13	2021-04-23	湘潭大学	一种多取代苯并咪唑并噻唑及衍生物及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1380507A (fr) *	1963-08-28	1964-12-04	Emballages Transparents Soc D	Procédé et dispositif pour la fabrication d'emballages se présentant sous forme de sachets multiples accolés ou superposés
US4214089A (en) *	1978-07-18	1980-07-22	American Home Products Corporation	Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response
US4361574A (en) *	1981-10-02	1982-11-30	American Home Products Corporation	Inhibitors of mammalian collagenase
US4466957A (en) *	1982-02-25	1984-08-21	American Home Products Corporation	Vaccine adjuvants

1987
- 1987-01-21 GB GB878701228A patent/GB8701228D0/en active Pending
- 1987-12-23 US US07/133,823 patent/US4812574A/en not_active Expired - Fee Related
1988
- 1988-01-19 AU AU10379/88A patent/AU602045B2/en not_active Ceased
- 1988-01-19 PT PT86567A patent/PT86567B/pt not_active IP Right Cessation
- 1988-01-19 IL IL85135A patent/IL85135A/xx not_active IP Right Cessation
- 1988-01-20 ES ES88300432T patent/ES2045098T3/es not_active Expired - Lifetime
- 1988-01-20 DK DK024088A patent/DK169819B1/da not_active IP Right Cessation
- 1988-01-20 DE DE8888300432T patent/DE3878700T2/de not_active Expired - Fee Related
- 1988-01-20 AT AT88300432T patent/ATE86257T1/de not_active IP Right Cessation
- 1988-01-20 JP JP63010569A patent/JP2555397B2/ja not_active Expired - Lifetime
- 1988-01-20 ZA ZA88378A patent/ZA88378B/xx unknown
- 1988-01-20 EP EP88300432A patent/EP0276133B1/de not_active Expired - Lifetime
- 1988-01-20 IE IE14388A patent/IE61348B1/en not_active IP Right Cessation
- 1988-01-20 HU HU88216A patent/HU201081B/hu not_active IP Right Cessation
- 1988-01-20 CA CA000556943A patent/CA1327042C/en not_active Expired - Fee Related
- 1988-01-20 GB GB8801219A patent/GB2200116B/en not_active Expired - Fee Related
- 1988-01-21 KR KR1019880000433A patent/KR960004536B1/ko not_active Expired - Fee Related
1989
- 1989-01-10 US US07/295,410 patent/US4889936A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR880009031A (ko)	1988-09-13
EP0276133B1 (de)	1993-03-03
JPS63198689A (ja)	1988-08-17
KR960004536B1 (ko)	1996-04-06
CA1327042C (en)	1994-02-15
IL85135A0 (en)	1988-06-30
HU201081B (en)	1990-09-28
EP0276133A3 (en)	1990-03-21
AU602045B2 (en)	1990-09-27
DE3878700T2 (de)	1993-06-09
ZA88378B (en)	1989-09-27
DK169819B1 (da)	1995-03-06
GB8801219D0 (en)	1988-02-17
IL85135A (en)	1992-07-15
US4889936A (en)	1989-12-26
DE3878700D1 (de)	1993-04-08
IE61348B1 (en)	1994-11-02
GB2200116A (en)	1988-07-27
DK24088A (da)	1988-07-06
DK24088D0 (da)	1988-01-20
GB8701228D0 (en)	1987-02-25
US4812574A (en)	1989-03-14
GB2200116B (en)	1991-06-12
PT86567B (pt)	1991-12-31
EP0276133A2 (de)	1988-07-27
PT86567A (en)	1988-02-01
IE880143L (en)	1988-07-21
JP2555397B2 (ja)	1996-11-20
HUT50835A (en)	1990-03-28
ES2045098T3 (es)	1994-01-16
AU1037988A (en)	1988-07-28

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Legal Events

Date	Code	Title	Description
1993-08-15	UEP	Publication of translation of european patent specification
2001-10-15	REN	Ceased due to non-payment of the annual fee