ATE87931T1 - PROCEDURE FOR PURIFICATION OF SPECIFIC OLIGONUCLEOTIDES. - Google Patents

PROCEDURE FOR PURIFICATION OF SPECIFIC OLIGONUCLEOTIDES.

Info

Publication number: ATE87931T1
Authority: AT; Austria
Prior art keywords: purification; procedure; specific oligonucleotides; oligonucleotides; specific
Prior art date: 1989-02-15

Application number

AT90903639T

Other languages

German (de)

Inventor

Sudhir Agrawal

Paul C Zamecnik

Original Assignee

Worcester Found Ex Biology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-15

Filing date

1990-02-15

Publication date

1993-04-15

1989-02-15 Priority claimed from US07/311,111 external-priority patent/US5352578A/en

1990-02-15 Application filed by Worcester Found Ex Biology filed Critical Worcester Found Ex Biology

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87931T1 publication Critical patent/ATE87931T1/en

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1

AT90903639T 1989-02-15 1990-02-15 PROCEDURE FOR PURIFICATION OF SPECIFIC OLIGONUCLEOTIDES. ATE87931T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/311,111 US5352578A (en)	1989-02-15	1989-02-15	Method of separating oligonucleotides from a mixture
EP90903639A EP0458876B1 (en)	1989-02-15	1990-02-15	Method of separating oligonucleotides from a mixture
PCT/US1990/000850 WO1990009393A1 (en)	1989-02-15	1990-02-15	Method of separating oligonucleotides from a mixture

Publications (1)

Publication Number	Publication Date
ATE87931T1 true ATE87931T1 (en)	1993-04-15

Family

ID=26128167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90903639T ATE87931T1 (en)	1989-02-15	1990-02-15	PROCEDURE FOR PURIFICATION OF SPECIFIC OLIGONUCLEOTIDES.

Country Status (1)

Country	Link
AT (1)	ATE87931T1 (en)

1990
- 1990-02-15 AT AT90903639T patent/ATE87931T1/en not_active IP Right Cessation

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Legal Events

Date	Code	Title	Description
1993-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties