ATE87932T1 - Alpha-oligonukleotide. - Google Patents

Alpha-oligonukleotide.

Info

Publication number: ATE87932T1
Authority: AT; Austria
Prior art keywords: compounds; chain; nucleotides; alpha; relates
Prior art date: 1986-12-02

Application number

AT88900022T

Other languages

English (en)

Inventor

Claude Helene

Jean-Louis Imbach

Thanh Thuong Nguyen

Claude Paoletti

Bernard Chenes-Colombie Rayner

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-02

Filing date

1987-12-02

Publication date

1993-04-15

1986-12-02 Priority claimed from FR8616797A external-priority patent/FR2607507B1/fr

1987-03-27 Priority claimed from FR8704339A external-priority patent/FR2612930B1/fr

1987-12-02 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87932T1 publication Critical patent/ATE87932T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
101710163270 Nuclease Proteins 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000000295 complement effect Effects 0.000 abstract 1
239000012636 effector Substances 0.000 abstract 1
230000002068 genetic effect Effects 0.000 abstract 1
238000009830 intercalation Methods 0.000 abstract 1
108020004999 messenger RNA Proteins 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

AT88900022T 1986-12-02 1987-12-02 Alpha-oligonukleotide. ATE87932T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR8616797A FR2607507B1 (fr)	1986-12-02	1986-12-02	Nouveaux derives a-d-oligonucleotides, leur preparation et leur emploi
FR8704339A FR2612930B1 (fr)	1987-03-27	1987-03-27	Sondes oligonucleotidiques a
EP88900022A EP0290583B1 (de)	1986-12-02	1987-12-02	Alpha-oligonukleotide
PCT/FR1987/000481 WO1988004301A1 (fr)	1986-12-02	1987-12-02	OLIGONUCLEOTIDES alpha

Publications (1)

Publication Number	Publication Date
ATE87932T1 true ATE87932T1 (de)	1993-04-15

Family

ID=26225619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88900022T ATE87932T1 (de)	1986-12-02	1987-12-02	Alpha-oligonukleotide.

Country Status (5)

Country	Link
EP (1)	EP0290583B1 (de)
JP (1)	JPH01502187A (de)
AT (1)	ATE87932T1 (de)
DE (1)	DE3785343T2 (de)
WO (1)	WO1988004301A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5789155A (en)	1987-10-30	1998-08-04	California Institute Of Technology	Process for identifying nucleic acids and triple helices formed thereby
US5874555A (en) *	1987-10-30	1999-02-23	California Institute Of Technology	Triple helices and processes for making same
FR2636633A1 (fr) *	1988-09-20	1990-03-23	Centre Nat Rech Scient	Procede de synthese d'oligoribonucleotides alpha et composes utiles dans le procede
IT1229477B (it) *	1989-03-13	1991-09-03	Bioresearch Spa	Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative
DE3916871A1 (de) *	1989-05-24	1990-11-29	Boehringer Mannheim Gmbh	Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
FR2648045B1 (fr) *	1989-06-13	1991-09-27	Centre Nat Rech Scient	Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
US5695926A (en) *	1990-06-11	1997-12-09	Bio Merieux	Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
FR2663040B1 (fr) *	1990-06-11	1995-09-15	Bio Merieux	Procede de detection d'une sequence nucleotidique selon la technique d'hybridation sandwich.
US5177196A (en) *	1990-08-16	1993-01-05	Microprobe Corporation	Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
FR2687679B1 (fr) *	1992-02-05	1994-10-28	Centre Nat Rech Scient	Oligothionucleotides.
US6403302B1 (en)	1992-09-17	2002-06-11	California Institute Of Technology	Methods and compositions for triple helix formation
CA2114355A1 (en) *	1993-01-29	1994-07-30	Hidehiko Furukawa	Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
FR2706618B1 (fr) *	1993-06-11	1995-09-01	Bio Merieux	Dispositif pour le dosage d'haptènes et son utilisation.
DE4418691A1 (de) *	1994-05-28	1996-02-22	Boehringer Mannheim Gmbh	3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
JP4207258B2 (ja) *	1998-08-31	2009-01-14	東ソー株式会社	特定核酸配列の切断方法
US7951926B2 (en) *	2006-04-28	2011-05-31	Centre National De La Recherche Scientifique (Cnrs)	Method for the synthesis of oligonucleotide derivatives
FR2906532B1 (fr) *	2006-09-28	2008-12-12	Biomerieux Sa	Nouvel oligonucleotide marque
FR2933410B1 (fr)	2008-07-04	2010-08-20	Biomerieux Sa	Nouvelle sonde de detection
CN116333006A (zh) *	2023-04-07	2023-06-27	苏州欧利生物医药科技有限公司	一种带有荧光标记物的寡核苷酸的固相合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1081497A (en) *	1976-06-02	1980-07-15	Robert J. Anderson	System for rate immunonephelometric analysis
US4204837A (en) *	1978-03-14	1980-05-27	Beckman Instruments, Inc.	Method of rate immunonephelometric analysis
FR2540122B1 (fr) *	1983-01-27	1985-11-29	Centre Nat Rech Scient	Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
FR2568254B1 (fr) *	1984-07-25	1988-04-29	Centre Nat Rech Scient	Application d'oligonucleotides lies a un agent intercalant, notamment a titre de medicament

1987
- 1987-12-02 WO PCT/FR1987/000481 patent/WO1988004301A1/fr not_active Ceased
- 1987-12-02 AT AT88900022T patent/ATE87932T1/de not_active IP Right Cessation
- 1987-12-02 DE DE8888900022T patent/DE3785343T2/de not_active Expired - Lifetime
- 1987-12-02 EP EP88900022A patent/EP0290583B1/de not_active Expired - Lifetime
- 1987-12-02 JP JP63500386A patent/JPH01502187A/ja active Pending

Also Published As

Publication number	Publication date
DE3785343D1 (de)	1993-05-13
WO1988004301A1 (fr)	1988-06-16
DE3785343T2 (de)	1993-07-22
EP0290583A1 (de)	1988-11-17
JPH01502187A (ja)	1989-08-03
EP0290583B1 (de)	1993-04-07

Legal Events

Date	Code	Title
1993-09-15	UEP	Publication of translation of european patent specification
2000-03-15	EEIH	Change in the person of patent owner
2003-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3785343D1 (de)	1993-05-13	Alpha-oligonukleotide.
Furuichi	1974	“Methylation-coupled” transcription by virus-associated transcriptase of cytoplasmic polyhedrosis virus containing double-stranded RNA
Beaudry et al.	1995	An efficient strategy for the synthesis of circular RNA molecules
Ortigão et al.	1992	Antisense effect of oligodeoxynucleotides with inverted terminal internucleotidic linkages: a minimal modification protecting against nucleolytic degradation
FI911152A0 (fi)	1991-03-07	Amplifikationsfoerfaranden av nukleinsyrasekvens.
US5859231A (en)	1999-01-12	Synthesis of oligonucleotides with boranophosphonate linkages
DK0517796T3 (da)	1995-07-03	Oligonukleotid-analoger
EP0902035A3 (de)	1999-06-23	Modifizierte, Temperaturstabile DNS-Polymerasen für Sequenzbestimmung
EP1185546A4 (de)	2002-08-21	Hochspezifische primer, expressionsverfahren und "kit"
DE69403642D1 (de)	1997-07-10	7-deazapurin modifizierte oligonukleotide
DE69838449D1 (de)	2007-10-31	Aminooxy-modifizierte oligonukleotide
WO1995006752A1 (en)	1995-03-09	A method of nucleic acid sequencing
AU3728897A (en)	1998-02-09	Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific Tm
ATE58143T1 (de)	1990-11-15	Verbindungen, enthaltend eine oligonukleotide sequenz, gebunden an eine interkalierungsverbindung und an eine aktivierbare chemische verbindung, ihre synthese und verwendungen als artifizielle sequenzspezifische nuklease.
PT98489A (pt)	1992-05-29	Processo para a producao de um grande polinucleotido ramificado do tipo combinado
AR018099A1 (es)	2001-10-31	Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion
DE69815370D1 (de)	2003-07-10	Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen
JPH09508282A (ja)	1997-08-26	短いオリゴヌクレオチドの配列決定法
Banerjee et al.	1967	Replication of RNA viruses, IV. Initiation of RNA synthesis by the q-beta RNA polymerase.
NO972868L (no)	1997-08-19	Oligonukleotid-dendrimer konjugater
Wu et al.	1978	Synthetic oligodeoxynucleotides for analyses of DNA structure and function
ES2081848T3 (es)	1996-03-16	Composiciones a base de conjugados de una enzima y de una hidrazona o hidrazina de un acido nucleico, sondas y metodos.
DE69009050D1 (de)	1994-06-23	Verfahren zur stabilisierung der hybridisierung von komplementären polynukleotidsequenzen.
ES2021482A6 (es)	1991-11-01	Procedimiento de preparacion de oligonucleotidos sinteticos y de amplificacion genica de sondas moleculares de adn especifico del fenoma macho de rumiantes.