ATE88723T1 - Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke. - Google Patents

Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.

Info

Publication number
ATE88723T1
ATE88723T1 AT88850184T AT88850184T ATE88723T1 AT E88723 T1 ATE88723 T1 AT E88723T1 AT 88850184 T AT88850184 T AT 88850184T AT 88850184 T AT88850184 T AT 88850184T AT E88723 T1 ATE88723 T1 AT E88723T1
Authority
AT
Austria
Prior art keywords
heparin
heparan sulfate
processes
production
pharmaceutical purposes
Prior art date
Application number
AT88850184T
Other languages
English (en)
Inventor
Karin Helena Louise Bergendal
Rolf Arne Johansson
Carl Magnus Erik Svahn
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Application granted granted Critical
Publication of ATE88723T1 publication Critical patent/ATE88723T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT88850184T 1987-05-29 1988-05-26 Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke. ATE88723T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8702254A SE8702254D0 (sv) 1987-05-29 1987-05-29 Novel heparin derivatives
EP88850184A EP0302034B1 (de) 1987-05-29 1988-05-26 Heparinderivate, Verfahren zu deren Herstellung und Verwendung für pharmazeutische Zwecke

Publications (1)

Publication Number Publication Date
ATE88723T1 true ATE88723T1 (de) 1993-05-15

Family

ID=20368699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88850184T ATE88723T1 (de) 1987-05-29 1988-05-26 Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.

Country Status (11)

Country Link
US (1) US5039529A (de)
EP (2) EP0319559A1 (de)
JP (1) JPH01503548A (de)
AT (1) ATE88723T1 (de)
AU (1) AU1936988A (de)
DE (1) DE3880577T2 (de)
DK (1) DK21989D0 (de)
ES (1) ES2054875T3 (de)
FI (1) FI890340A7 (de)
SE (1) SE8702254D0 (de)
WO (1) WO1988009347A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
ATE129254T1 (de) * 1987-03-19 1995-11-15 Arthropharm Pty Ltd Antientzündungsmittel und zusammensetzungen.
NL8900119A (nl) * 1989-01-19 1990-08-16 Akzo Nv Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten.
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
JPH06507635A (ja) * 1991-05-02 1994-09-01 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド 病理学的過程の予防および／または治療用組成物
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5593664A (en) * 1992-08-19 1997-01-14 Merrell Pharmaceuticals Inc. Antiangiogenic oligomers
US5958883A (en) * 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5847007A (en) 1993-05-13 1998-12-08 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1994020520A1 (en) * 1993-03-10 1994-09-15 Magainin Pharmaceuticals Inc. Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
AU1831195A (en) * 1994-01-13 1995-08-01 Research Foundation For Mental Hygiene, Inc. Methods and compositions for treatment and diagnosis of alzheimer disease and other disorders
US5783568A (en) * 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
DE4429660B4 (de) 1994-08-20 2004-02-12 Dade Behring Marburg Gmbh Zusatzmittel für diagnostische Tests zur Bestimmung der Gerinnungsfähigkeit des Blutes, Verfahren zur Reduzierung der Beeinflussung von diagnostischen Tests durch Heparin und Verwendung von Metallsalzen zu diesen Zwecken
US7404967B2 (en) * 1994-12-21 2008-07-29 Cosmederm, Inc. Topical product formulations containing strontium for reducing skin irritation
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
WO1997016556A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
PT910382E (pt) * 1996-04-26 2003-10-31 Genaera Corp Esqualamina em combinacao com outros agentes anti-cancro para o tratamento de tumores
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
EP1109919A2 (de) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Von heparinase i und ii abgeleitete heparinasen
US7412332B1 (en) 1999-04-23 2008-08-12 Massachusetts Institute Of Technology Method for analyzing polysaccharides
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
DK1274718T3 (da) * 2000-04-12 2007-02-12 Genaera Corp En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe
DE10028204A1 (de) * 2000-06-09 2002-01-03 Aventis Pharma Gmbh Verfahren zur Auffindung von medizinisch wertvollen Wirkstoffen
ATE426805T1 (de) 2000-09-12 2009-04-15 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
AU2440802A (en) * 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
CA2458651C (en) * 2001-08-31 2011-11-29 Ivax Research, Inc. Saccharide sulfation methods
US6932978B2 (en) 2001-10-18 2005-08-23 James Benjamin Huntley Double-headed, closed-mouth cough suppressant and cold relief device
SE521676C2 (sv) 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
JP4828795B2 (ja) * 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN1234371C (zh) * 2003-01-28 2006-01-04 马驷 纳米铜粉作为制备预防治疗骨质疏松、骨折药物的应用
US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
EP3153159A1 (de) * 2004-07-09 2017-04-12 Robert Sabin Zusammensetzungen mit einer kupferverbindung zur behandlung von erkrankungen bei säugetieren
FR2880951B1 (fr) * 2005-01-19 2015-09-18 Aventis Pharma Sa Methode d'analyse d'oligosaccharides a partir de plasma sanguin
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
WO2011090948A1 (en) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
FR2956322A1 (fr) 2010-02-17 2011-08-19 Urgo Lab Utilisation d'oligosaccharides polysulfates synthetiques comme agents de detersion d'une plaie.
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
JP5998159B2 (ja) 2011-03-10 2016-09-28 ヴィクトリア リンク リミテッドＶｉｃｔｏｒｉａ Ｌｉｎｋ Ｌｉｍｉｔｅｄ オリゴ糖化合物
CN104672344B (zh) * 2015-03-25 2017-03-29 福建农林大学 一种浒苔功能性寡糖锌及其制备方法
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
CN112079942A (zh) * 2019-06-14 2020-12-15 苏州融析生物科技有限公司 一种甲基化肝素化合物及其制备和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE890622C (de) * 1941-10-21 1953-09-21 Joseph Elliott Kennedy Vorrichtung zum Behandeln von Schuettgut mit Gasen
CH387007A (fr) * 1958-12-15 1965-01-31 Fo We Forschungs Und Verwertun Procédé de préparation d'un complexe à action thérapeutique
FR6853M (de) * 1967-12-08 1969-04-08
CA1042001A (en) * 1973-04-13 1978-11-07 Choay S.A. Mixed heparin salts
JPS5446809A (en) * 1977-08-08 1979-04-13 Choay Sa Purifying of heparine
IT1141263B (it) * 1980-02-29 1986-10-01 Italfarmaco Spa Metodo per la preparazione di eparinato di calcio
HU193769B (en) * 1985-06-04 1987-11-30 Richter Gedeon Vegyeszet Sodium-exchanging process for producing pharmaceutically acceptable heparinates applicable even for injections

Also Published As

Publication number Publication date
SE8702254D0 (sv) 1987-05-29
US5039529A (en) 1991-08-13
AU1936988A (en) 1988-12-21
EP0302034A1 (de) 1989-02-01
EP0319559A1 (de) 1989-06-14
EP0302034B1 (de) 1993-04-28
FI890340A0 (fi) 1989-01-24
DK21989A (da) 1989-01-19
DK21989D0 (da) 1989-01-19
FI890340L (fi) 1989-01-24
JPH01503548A (ja) 1989-11-30
FI890340A7 (fi) 1989-01-24
WO1988009347A1 (en) 1988-12-01
ES2054875T3 (es) 1994-08-16
DE3880577D1 (de) 1993-06-03
DE3880577T2 (de) 1993-08-26

Similar Documents

Publication Publication Date Title
ATE88723T1 (de) Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.
GB2243155B (en) Improved shop primer compositions
DE3750399D1 (de) Desinfizierende Polymerbeschichtungen für harte Oberflächen.
IL109580A0 (en) Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
CA2022392A1 (en) 4-phosphonomethyl-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane n-oxide and water-soluble salts thereof
GB8716928D0 (en) Corrosion resistant steel components
DE69204680D1 (de) Tonerzusammensetzung zur Fixierung nach dem kontaktfreien Schmelzverfahren.
IT8319880A0 (it) Procedimento per la protezione di laminati piani di acciaio zincato mediante rivestimento elettrolitico multistrato.
BR9916187A (pt) Processo para a preparação de 3-alcanoìla e 3-alquilindóis
ATE133556T1 (de) Aminosäure-beta-lyase-enzyminhibitoren als deodorantien
DE59008005D1 (de) Verfahren zur Herstellung von hochmolekularen Copolyarylensulfiden.
EP0409052A3 (en) Anticoagulant containing agent
IT8123121A0 (it) Processi e composizioni per la formazione di rivestimenti fosfatici.
FI902475A7 (fi) Massapolykondensointimenetelmä N-diklorofosforyyli- tai N-diklorofosforyyli-P-triklorofosfatsiinille
EP0251339A3 (de) N6-substituierte Diarylalkyl-Adenosine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE69010030D1 (de) Verfahren zur Produktion von Fruktose-1,6-diphosphat.
ZA883444B (de)
IE851204L (en) Beta-carbolines
DE3366933D1 (en) Antithrombin-heparin complex
BR8902021A (pt) Processo para a preparacao de fosfatos de titanio(vi)polimeros,aplicacao de tais fosfatos,e processo para ativacao de superficies metalicas de ferro,aco,zinco,ferro zincado ou aco zincado,aluminio e/ou aco aluminizado,antes da fosfatacao com banhos de fosfatacao contendo ions zinco
IT1247633B (it) Imbracatura per sega da disboscamento o similare
AU624533B2 (en) Corrosion resistant coating composition
SG44391G (en) Hexahydropyrrolo (2, 1-a) isoquinoline derivatives
GR3007141T3 (de)
ES8505363A1 (es) Un procedimiento para preparar una 3-(2-furoil)-5-2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee