ATE89547T1 - Dopamin-vorlaeufer. - Google Patents
Dopamin-vorlaeufer.Info
- Publication number
- ATE89547T1 ATE89547T1 AT89114012T AT89114012T ATE89547T1 AT E89547 T1 ATE89547 T1 AT E89547T1 AT 89114012 T AT89114012 T AT 89114012T AT 89114012 T AT89114012 T AT 89114012T AT E89547 T1 ATE89547 T1 AT E89547T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- formula
- dopamine precursors
- parkinson
- hypertension
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8821543A IT1226727B (it) | 1988-07-29 | 1988-07-29 | Farmaci precursori della dopamina. |
| EP89114012A EP0352815B1 (de) | 1988-07-29 | 1989-07-28 | Dopamin-Vorläufer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE89547T1 true ATE89547T1 (de) | 1993-06-15 |
Family
ID=11183351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89114012T ATE89547T1 (de) | 1988-07-29 | 1989-07-28 | Dopamin-vorlaeufer. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5013753A (de) |
| EP (1) | EP0352815B1 (de) |
| JP (1) | JPH0296556A (de) |
| AT (1) | ATE89547T1 (de) |
| DE (1) | DE68906609T2 (de) |
| ES (1) | ES2054949T3 (de) |
| IT (1) | IT1226727B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04506967A (ja) * | 1989-07-27 | 1992-12-03 | ジー．ディー．サール アンド カンパニー | 高血圧症治療用腎選択性生成物 |
| DK1196414T3 (da) * | 1999-06-25 | 2003-11-24 | Vertex Pharma | Prolægemiddel af carbamathæmmer for IMPDH |
| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| DE102005022276A1 (de) * | 2005-05-13 | 2006-11-16 | Ellneuroxx Ltd. | Derivate von Dihydroxyphenylalanin |
| TWI389889B (zh) * | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| EP2021325A2 (de) * | 2006-05-09 | 2009-02-11 | AstraZeneca AB | Salzformen von (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amin |
| WO2008091588A1 (en) * | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| GB0713189D0 (en) * | 2007-07-06 | 2007-08-15 | Proximagen Ltd | Amino acid derivatives |
| ES2322121B1 (es) * | 2007-12-10 | 2010-04-19 | Consejo Superior De Investigaciones Cientificas | Nuevos derivados de aminoacidos dicarboxilicos y su aplicacion en el tratamiento de enfermedades neurodegenerativas. |
| CN103180277A (zh) | 2010-05-20 | 2013-06-26 | 塔格塞普特股份有限公司 | 制备芳基取代的烯属胺的新方法 |
| BR112015022896B1 (pt) | 2013-03-15 | 2022-08-23 | Chongxi Yu | Composto de fármacos de alta penetração, composição farmacêutica e seus usos para o tratamento de doenças de parkinson |
| MX393568B (es) | 2014-10-21 | 2025-03-24 | Abbvie Inc | Profarmacos de carbidopa y l-dopa y metodos de uso |
| CR20200225A (es) | 2017-11-24 | 2020-07-25 | H Lundbeck As | Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson |
| JP6596483B2 (ja) * | 2017-12-28 | 2019-10-23 | テックフィールズ ファーマ カンパニー リミテッド | パ−キンソン病治療用の新規高透過薬物及びその組成物 |
| UY38473A (es) | 2018-11-15 | 2020-06-30 | Abbvie Inc | Formulaciones farmacéuticas para una administración subcutánea |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| JP7641234B2 (ja) | 2019-05-21 | 2025-03-06 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| EP3972971A1 (de) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | Neue catecholamin-prodrugs zur verwendung in der behandlung von morbus parkinson |
| EP3972600B1 (de) | 2019-05-21 | 2026-02-18 | H. Lundbeck A/S | Catecholamin-carbamat-prodrugs zur verwendung bei der behandlung von morbus parkinson |
| JP7562562B2 (ja) | 2019-05-21 | 2024-10-07 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947590A (en) * | 1973-10-23 | 1976-03-30 | Abbott Laboratories | Compositions and methods of increasing renal blood flow with gamma-glutamyl amide of dopamine |
| US3891696A (en) * | 1973-11-02 | 1975-06-24 | Interx Research Corp | Novel, transient pro-drug forms of l-dopa |
| US4035507A (en) * | 1975-04-17 | 1977-07-12 | Interx Research Corporation | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease |
| US4031242A (en) * | 1975-09-11 | 1977-06-21 | Abbott Laboratories | Diacylated derivatives of γ-glutamyl dopamine |
| US4125626A (en) * | 1977-01-17 | 1978-11-14 | Mt. Sinai School Of Medicine Of The City University Of New York | Synthesis and use of L-γ-glutamyl-DOPA |
-
1988
- 1988-07-29 IT IT8821543A patent/IT1226727B/it active
-
1989
- 1989-07-28 ES ES89114012T patent/ES2054949T3/es not_active Expired - Lifetime
- 1989-07-28 DE DE8989114012T patent/DE68906609T2/de not_active Expired - Fee Related
- 1989-07-28 US US07/386,106 patent/US5013753A/en not_active Expired - Lifetime
- 1989-07-28 EP EP89114012A patent/EP0352815B1/de not_active Expired - Lifetime
- 1989-07-28 AT AT89114012T patent/ATE89547T1/de not_active IP Right Cessation
- 1989-07-28 JP JP1197894A patent/JPH0296556A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0296556A (ja) | 1990-04-09 |
| EP0352815A1 (de) | 1990-01-31 |
| DE68906609T2 (de) | 1993-08-26 |
| EP0352815B1 (de) | 1993-05-19 |
| IT1226727B (it) | 1991-02-05 |
| US5013753A (en) | 1991-05-07 |
| DE68906609D1 (de) | 1993-06-24 |
| ES2054949T3 (es) | 1994-08-16 |
| IT8821543A0 (it) | 1988-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE68906609D1 (de) | Dopamin-vorlaeufer. | |
| FI872864A0 (fi) | Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi | |
| ES2070994T3 (es) | Profarmaco de dopamina. | |
| EP0303697A4 (de) | Derivate des physiologisch aktiven mittels k-252. | |
| MX9203417A (es) | Compuestos de diarilo antiateroescleroticos. | |
| IT1228288B (it) | Composti ad attivita' antiserotoninica | |
| DE3882679D1 (de) | Kardiovaskulaer aktive verbindungen. | |
| ES2111352T3 (es) | Uso de diester fosfato para el tratamiento de enfermedades retinianas. | |
| EG19302A (en) | Compound with gastric acid inhibitory effect and process for its preparation | |
| SE8600658D0 (sv) | Novel composition of matter | |
| DE3584608D1 (de) | Amidabkoemmlinge. | |
| MA21026A1 (fr) | Derives de 4-(aroylamino) piperidinebutanamide, et leur procede de preparation | |
| DE69402004D1 (de) | Beta-mercapto-propanamidderivate verwendbar zur Behandlung kardiovaskularer Krankheiten oder Erkrankungen | |
| IT1216104B (it) | Peptidi ad attivita' farmaceutica. | |
| RU94040865A (ru) | Производные пептида и их терапевтически приемлемые соли, способ их получения, фармацевтическая и косметическая композиция с антивирусной активностью | |
| DK0420224T3 (da) | Anthihepatopatisk middel | |
| ATE88176T1 (de) | 2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung. | |
| IT1241927B (it) | 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono | |
| IT1204960B (it) | Composti dotati di attivita' antiallergica | |
| DE3882677D1 (de) | Kardiovaskulaer aktive verbindungen. | |
| ATE81466T1 (de) | Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz. | |
| AU2013888A (en) | Uricosuric composition | |
| IT1204959B (it) | Composti dotati di attivita' antiallergica | |
| DK460789D0 (da) | 2-aminoacetamidderivater | |
| RU92016559A (ru) | Производные диалкокси-пиридинилбензимидазола, фармацевтическая композиция, способ ингибирования или лечения, способ их получения, применение и промежуточные соединения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |