ATE92058T1 - Pyrimidin-derivate, 2-(4-(alpha-heteroaryl-alphaaryl-(alpha-alkyl)-methoxy)-butyl)-1-piperaziny > mit serotoninergischer wirkung. - Google Patents
Pyrimidin-derivate, 2-(4-(alpha-heteroaryl-alphaaryl-(alpha-alkyl)-methoxy)-butyl)-1-piperaziny > mit serotoninergischer wirkung.Info
- Publication number
- ATE92058T1 ATE92058T1 AT90400336T AT90400336T ATE92058T1 AT E92058 T1 ATE92058 T1 AT E92058T1 AT 90400336 T AT90400336 T AT 90400336T AT 90400336 T AT90400336 T AT 90400336T AT E92058 T1 ATE92058 T1 AT E92058T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- alphaaryl
- piperaziny
- heteroaryl
- methoxy
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 230000002295 serotoninergic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8901699A FR2642758B1 (fr) | 1989-02-09 | 1989-02-09 | Derives de pyrimidine,2-(4-((alpha)-heteroaryl-(alpha) aryl-((alpha)-alkyl)-methoxy)-butyl)-1-piperazinyl), avec activite serotoninergique |
| EP90400336A EP0382636B1 (de) | 1989-02-09 | 1990-02-07 | Pyrimidin-Derivate, 2-[4-(Alpha-heteroaryl-alpha-aryl-(alpha-alkyl)-methoxy)-butyl)-1-piperazinyl] mit serotoninergischer Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE92058T1 true ATE92058T1 (de) | 1993-08-15 |
Family
ID=9378641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90400336T ATE92058T1 (de) | 1989-02-09 | 1990-02-07 | Pyrimidin-derivate, 2-(4-(alpha-heteroaryl-alphaaryl-(alpha-alkyl)-methoxy)-butyl)-1-piperaziny > mit serotoninergischer wirkung. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0382636B1 (de) |
| AT (1) | ATE92058T1 (de) |
| DE (1) | DE69002340T2 (de) |
| ES (1) | ES2021940A6 (de) |
| FR (1) | FR2642758B1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI895821A7 (fi) * | 1988-12-07 | 1990-06-08 | The Wellcome Foundation Ltd | Farmaseuttisesti aktivisia CNS-yhdisteitä |
| GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| US5656762A (en) | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
| US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
-
1989
- 1989-02-09 FR FR8901699A patent/FR2642758B1/fr not_active Expired - Lifetime
-
1990
- 1990-02-07 AT AT90400336T patent/ATE92058T1/de not_active IP Right Cessation
- 1990-02-07 EP EP90400336A patent/EP0382636B1/de not_active Expired - Lifetime
- 1990-02-07 DE DE90400336T patent/DE69002340T2/de not_active Expired - Fee Related
- 1990-02-08 ES ES9000368A patent/ES2021940A6/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2642758A1 (fr) | 1990-08-10 |
| FR2642758B1 (fr) | 1991-05-17 |
| EP0382636B1 (de) | 1993-07-28 |
| DE69002340D1 (de) | 1993-09-02 |
| DE69002340T2 (de) | 1993-12-02 |
| ES2021940A6 (es) | 1991-11-16 |
| EP0382636A1 (de) | 1990-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |