ATE921T1 - ACID ADDITIONAL SALTS OF 2-BETA, 16-BETA-BIS-PIPERIDINO-AN DROSTAN-16-BETA-MONOQUATERNARY AMMONIUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents

ACID ADDITIONAL SALTS OF 2-BETA, 16-BETA-BIS-PIPERIDINO-AN DROSTAN-16-BETA-MONOQUATERNARY AMMONIUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Info

Publication number
ATE921T1
ATE921T1 AT79200452T AT79200452T ATE921T1 AT E921 T1 ATE921 T1 AT E921T1 AT 79200452 T AT79200452 T AT 79200452T AT 79200452 T AT79200452 T AT 79200452T AT E921 T1 ATE921 T1 AT E921T1
Authority
AT
Austria
Prior art keywords
beta
drostan
piperidino
bis
pharmaceutical compositions
Prior art date
Application number
AT79200452T
Other languages
German (de)
Inventor
Ian Craig Carlyle
Thomas Sleigh
David Samuel Savage
Original Assignee
Akzo N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo N.V. filed Critical Akzo N.V.
Application granted granted Critical
Publication of ATE921T1 publication Critical patent/ATE921T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
AT79200452T 1978-09-05 1979-08-15 ACID ADDITIONAL SALTS OF 2-BETA, 16-BETA-BIS-PIPERIDINO-AN DROSTAN-16-BETA-MONOQUATERNARY AMMONIUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. ATE921T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7835667 1978-09-05
EP79200452A EP0008824B1 (en) 1978-09-05 1979-08-15 Acid addition salts of 16-beta-monoquaternary ammonium derivatives of 2-beta, 16-beta-bis-piperidino-androstanes and pharmaceutical preparations containing same

Publications (1)

Publication Number Publication Date
ATE921T1 true ATE921T1 (en) 1982-05-15

Family

ID=10499453

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79200452T ATE921T1 (en) 1978-09-05 1979-08-15 ACID ADDITIONAL SALTS OF 2-BETA, 16-BETA-BIS-PIPERIDINO-AN DROSTAN-16-BETA-MONOQUATERNARY AMMONIUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Country Status (20)

Country Link
US (2) US4237126A (en)
EP (1) EP0008824B1 (en)
JP (1) JPS5535098A (en)
AR (1) AR228728A1 (en)
AT (1) ATE921T1 (en)
AU (1) AU526270B2 (en)
CA (1) CA1134813A (en)
DE (1) DE2962627D1 (en)
DK (1) DK159119C (en)
ES (1) ES483894A1 (en)
FI (1) FI66881C (en)
GR (1) GR72520B (en)
HU (1) HU181847B (en)
IE (1) IE50376B1 (en)
IL (1) IL58080A (en)
NO (1) NO151367C (en)
NZ (1) NZ191462A (en)
PH (1) PH16041A (en)
PT (1) PT70126A (en)
ZA (1) ZA794371B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
US5238957A (en) * 1988-07-07 1993-08-24 Presidenza Del Consiglio Dei Ministri-Uffico Del Ministro Per Il Coordinamento Delle Iniziative Per La Ricerca Scientifica E Tecnologica Esters of 2,2-dimethyl-cyclopropane-carboxylic acid
US5418226A (en) * 1992-04-22 1995-05-23 Akzo N.V. Monoquaternary 2,16-bispiperidinylandrostane derivatives
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
US5767112A (en) * 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
US5553456A (en) * 1995-05-17 1996-09-10 Ramco, Inc. Clathrate freeze desalination apparatus and method
IT1277700B1 (en) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa PROCESS OF PREPARATION OF 2-BETA, 16-BETA-DIAMINO 3-ALPHA, 17-BETA-DIACYLOSS 5-ALPHAANDROSTANS, STRUCTURED NEUROMUSCULAR BLOCKERS
HU0402017D0 (en) * 2004-10-07 2004-12-28 Richter Gedeon Vegyeszet Environment-friend process for the synthesis of quaternary ammonio-steroids
WO2006038047A1 (en) * 2004-10-07 2006-04-13 Richter Gedeon Vegyészeti Gyár Rt. Environment-friend process for the synthesis of quaternary ammonio-steroιds
AU2006236616A1 (en) * 2005-04-15 2006-10-26 Lyotropic Therapeutics, Inc. Formulations of quaternary ammonium neuromuscular blocking agents
DE102005030423A1 (en) * 2005-06-30 2007-01-04 Inresa Arzneimittel Gmbh New formulation for vecuronium bromide
CN101588803B (en) 2006-12-06 2013-03-20 康乃尔研究基金会有限公司 Intermediate duration neuromuscular blocking agents and antagonists thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
WO2022078483A1 (en) * 2020-10-15 2022-04-21 江苏恩华络康药物研发有限公司 Quaternary ammonium steroid compound, preparation method therefor, preparation and use
CN116925171B (en) * 2023-07-10 2025-06-27 时森海(杭州)医药科技有限公司 Cyclopropylmethyl steroid quaternary ammonium salt-containing compound, intermediate, preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
HU171166B (en) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Process for preparing new epoxy-androstanes
HU172522B (en) * 1975-08-01 1978-09-28 Richter Gedeon Vegyeszet Process for preparing new derivatives of 2beta-16beta-diamino-androstane and derivatives / quaternary salts / thereof
US4177190A (en) * 1975-08-01 1979-12-04 Richter Gedeon Vegyeszeti Gyar Rt. Diamino-androstanes and a process for the preparation of the said compounds

Also Published As

Publication number Publication date
PH16041A (en) 1983-06-02
ZA794371B (en) 1980-08-27
AU5034879A (en) 1980-03-13
US4237126A (en) 1980-12-02
IE791593L (en) 1980-03-05
HU181847B (en) 1983-11-28
IL58080A (en) 1982-12-31
AR228728A1 (en) 1983-04-15
JPS5535098A (en) 1980-03-11
ES483894A1 (en) 1980-09-01
FI66881C (en) 1984-12-10
AU526270B2 (en) 1982-12-23
NO151367B (en) 1984-12-17
JPS6245879B2 (en) 1987-09-29
US4297351A (en) 1981-10-27
IE50376B1 (en) 1986-04-16
DK159119B (en) 1990-09-03
FI66881B (en) 1984-08-31
NZ191462A (en) 1982-03-16
DE2962627D1 (en) 1982-06-09
NO792810L (en) 1980-03-06
EP0008824B1 (en) 1982-04-28
IL58080A0 (en) 1979-12-30
PT70126A (en) 1979-09-01
CA1134813A (en) 1982-11-02
FI792745A7 (en) 1980-03-06
GR72520B (en) 1983-11-16
EP0008824A1 (en) 1980-03-19
DK361779A (en) 1980-03-06
NO151367C (en) 1985-03-27
DK159119C (en) 1991-03-11

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties