ATE94535T1 - 4-amino-3-acylchinolin-derivate und ihre verwendung als inhibitoren der magensekretion. - Google Patents
4-amino-3-acylchinolin-derivate und ihre verwendung als inhibitoren der magensekretion.Info
- Publication number
- ATE94535T1 ATE94535T1 AT89301802T AT89301802T ATE94535T1 AT E94535 T1 ATE94535 T1 AT E94535T1 AT 89301802 T AT89301802 T AT 89301802T AT 89301802 T AT89301802 T AT 89301802T AT E94535 T1 ATE94535 T1 AT E94535T1
- Authority
- AT
- Austria
- Prior art keywords
- 6alkyl
- amino
- inhibitors
- gasgase
- secretion
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000028327 secretion Effects 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888804443A GB8804443D0 (en) | 1988-02-25 | 1988-02-25 | Compounds |
| EP89301802A EP0342775B1 (de) | 1988-02-25 | 1989-02-23 | 4-Amino-3-acylchinolin-Derivate und ihre Verwendung als Inhibitoren der Magensekretion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE94535T1 true ATE94535T1 (de) | 1993-10-15 |
Family
ID=10632375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89301802T ATE94535T1 (de) | 1988-02-25 | 1989-02-23 | 4-amino-3-acylchinolin-derivate und ihre verwendung als inhibitoren der magensekretion. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5143920A (de) |
| EP (1) | EP0342775B1 (de) |
| JP (1) | JPH02503316A (de) |
| KR (1) | KR900700458A (de) |
| CN (1) | CN1035663A (de) |
| AT (1) | ATE94535T1 (de) |
| AU (1) | AU3181789A (de) |
| DE (1) | DE68909107T2 (de) |
| DK (1) | DK528789A (de) |
| FI (1) | FI895046A7 (de) |
| GB (1) | GB8804443D0 (de) |
| HU (1) | HU891462D0 (de) |
| PT (1) | PT89788B (de) |
| WO (1) | WO1989008105A1 (de) |
| ZA (1) | ZA891389B (de) |
| ZW (1) | ZW1889A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804444D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| CA2011086A1 (en) * | 1989-03-17 | 1990-09-17 | Karl-Heinz Geiss | 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom |
| GB8918265D0 (en) * | 1989-08-10 | 1989-09-20 | Smithkline Beckman Intercredit | Compounds |
| WO1991014677A1 (en) * | 1990-03-28 | 1991-10-03 | Otsuka Pharmaceutical Co., Ltd. | Quinoline derivative, antiulcer drug containing the same, and production of said derivative |
| MX9200299A (es) * | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
| FR2672596B1 (fr) * | 1991-02-07 | 1995-07-13 | Roussel Uclaf | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| FR2680510B1 (fr) * | 1991-08-20 | 1995-06-23 | Roussel Uclaf | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| GB9127252D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| US5362743A (en) * | 1993-03-09 | 1994-11-08 | Pfizer Inc. | Aminoquinoline derivatives |
| US5556863A (en) * | 1993-06-11 | 1996-09-17 | Astra Aktiebolag | Compound for gastric acid secretion inhibition |
| IS4164A (is) * | 1993-06-11 | 1994-12-12 | Ab Astra | Efnasambönd sem hindra flæði magasýru |
| US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
| BRPI9914164B8 (pt) | 1998-09-29 | 2021-05-25 | American Cyanamid Co | compostos de 3-ciano quinolina |
| CN1304374C (zh) * | 2002-04-30 | 2007-03-14 | 永进药品工业株式会社 | 可用做caspase－3抑制剂的喹啉衍生物及其制备方法和药用组合物 |
| FR2873695A1 (fr) * | 2004-07-30 | 2006-02-03 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien |
| EP3700527A4 (de) * | 2017-10-25 | 2021-03-10 | Children's Medical Center Corporation | Papd5-inhibitoren und verfahren zur verwendung davon |
| EP3959197A4 (de) | 2019-04-24 | 2022-10-12 | Children's Medical Center Corporation | Papd5-inhibitoren und verfahren zur verwendung davon |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2652398A (en) * | 1949-11-17 | 1953-09-15 | Endo Products Inc | N-substituted-2-amino (methyl) quinolines |
| US3391146A (en) * | 1964-11-10 | 1968-07-02 | Bristol Myers Co | Nu-substituted carbamates and thiocarbamates of 2-quinolinemethanols |
| US3470186A (en) * | 1967-06-02 | 1969-09-30 | American Cyanamid Co | Substituted 4-anilino-3-quinolinecarboxylic acids and esters |
| CA942748A (en) * | 1970-09-18 | 1974-02-26 | Venkatachala L. Narayanan | 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds |
| US4343804A (en) * | 1979-03-26 | 1982-08-10 | A. H. Robins Company, Inc. | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds |
| US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
| GB8621425D0 (en) * | 1986-09-05 | 1986-10-15 | Smith Kline French Lab | Compounds |
-
1988
- 1988-02-25 GB GB888804443A patent/GB8804443D0/en active Pending
-
1989
- 1989-02-20 ZW ZW18/89A patent/ZW1889A1/xx unknown
- 1989-02-20 AU AU31817/89A patent/AU3181789A/en not_active Abandoned
- 1989-02-20 FI FI895046A patent/FI895046A7/fi not_active Application Discontinuation
- 1989-02-20 HU HU891462A patent/HU891462D0/hu unknown
- 1989-02-20 JP JP1502449A patent/JPH02503316A/ja active Pending
- 1989-02-20 WO PCT/EP1989/000173 patent/WO1989008105A1/en not_active Ceased
- 1989-02-22 PT PT89788A patent/PT89788B/pt not_active IP Right Cessation
- 1989-02-23 US US07/314,684 patent/US5143920A/en not_active Expired - Fee Related
- 1989-02-23 EP EP89301802A patent/EP0342775B1/de not_active Expired - Lifetime
- 1989-02-23 AT AT89301802T patent/ATE94535T1/de not_active IP Right Cessation
- 1989-02-23 ZA ZA891389A patent/ZA891389B/xx unknown
- 1989-02-23 DE DE89301802T patent/DE68909107T2/de not_active Expired - Fee Related
- 1989-02-24 CN CN89100928A patent/CN1035663A/zh active Pending
- 1989-10-24 KR KR1019890701952A patent/KR900700458A/ko not_active Withdrawn
- 1989-10-24 DK DK528789A patent/DK528789A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK528789D0 (da) | 1989-10-24 |
| FI895046A0 (fi) | 1989-10-24 |
| AU3181789A (en) | 1989-09-22 |
| PT89788A (pt) | 1989-10-04 |
| HU891462D0 (en) | 1990-01-28 |
| FI895046A7 (fi) | 1989-10-24 |
| JPH02503316A (ja) | 1990-10-11 |
| ZW1889A1 (en) | 1989-09-13 |
| EP0342775B1 (de) | 1993-09-15 |
| PT89788B (pt) | 1994-05-31 |
| EP0342775A1 (de) | 1989-11-23 |
| DE68909107T2 (de) | 1994-02-17 |
| WO1989008105A1 (en) | 1989-09-08 |
| DE68909107D1 (de) | 1993-10-21 |
| US5143920A (en) | 1992-09-01 |
| DK528789A (da) | 1989-10-24 |
| ZA891389B (en) | 1990-10-31 |
| KR900700458A (ko) | 1990-08-13 |
| CN1035663A (zh) | 1989-09-20 |
| GB8804443D0 (en) | 1988-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |