ATE945T1 - ANTICOAGULANT AGENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT. - Google Patents

ANTICOAGULANT AGENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT.

Info

Publication number
ATE945T1
ATE945T1 AT79200596T AT79200596T ATE945T1 AT E945 T1 ATE945 T1 AT E945T1 AT 79200596 T AT79200596 T AT 79200596T AT 79200596 T AT79200596 T AT 79200596T AT E945 T1 ATE945 T1 AT E945T1
Authority
AT
Austria
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
anticoagulant agents
sulphatation
Prior art date
Application number
AT79200596T
Other languages
German (de)
Inventor
Gunnvoer Rothman
Ulf Sven Erik Rothman
Original Assignee
Akzo N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo N.V. filed Critical Akzo N.V.
Application granted granted Critical
Publication of ATE945T1 publication Critical patent/ATE945T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seal Device For Vehicle (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

The invention relates to an anticoagulant agent which acts without cofactor and selectively inhibits thrombin, and to pharmaceutical preparations containing said agent. The anticoagulant agent is prepared by sulphatation of a polysaccharide obtained by precipitation from the decoction of mollusca, preferably common sea mussels. Sulphatation is preferably achieved with chlorosulphonic acid in the presence of pyridine.
AT79200596T 1978-11-01 1979-10-17 ANTICOAGULANT AGENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT. ATE945T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7811306A SE7811306L (en) 1978-11-01 1978-11-01 ANTICOAGULATOR AND SET FOR ITS PREPARATION
EP79200596A EP0011322B1 (en) 1978-11-01 1979-10-17 Anticoagulant agent, process for the preparation thereof and pharmaceutical preparations containing same

Publications (1)

Publication Number Publication Date
ATE945T1 true ATE945T1 (en) 1982-05-15

Family

ID=20336233

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79200596T ATE945T1 (en) 1978-11-01 1979-10-17 ANTICOAGULANT AGENTS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT.

Country Status (13)

Country Link
EP (1) EP0011322B1 (en)
JP (1) JPS5564523A (en)
AT (1) ATE945T1 (en)
AU (1) AU5204579A (en)
DE (1) DE2962725D1 (en)
DK (1) DK459679A (en)
ES (1) ES485623A1 (en)
FI (1) FI793375A7 (en)
NO (1) NO793474L (en)
NZ (1) NZ191991A (en)
PT (1) PT70352A (en)
SE (1) SE7811306L (en)
ZA (1) ZA795596B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57130918A (en) * 1981-02-09 1982-08-13 Cosmo Co Ltd Preparation of antitumor agent
JPS5927831A (en) * 1982-08-09 1984-02-14 Cosmo Co Ltd Antitumor substance
FR2538404B1 (en) * 1982-12-28 1985-08-23 Anic Spa
FR2584728B1 (en) * 1985-07-12 1987-11-20 Choay Sa PROCESS FOR THE SULFATION OF GLYCOSAMINOGLYCANS AND THEIR FRAGMENTS
SE453394B (en) * 1986-07-07 1988-02-01 Pharmacia Ab PROCEDURE FOR PREPARING SULPHATATED POLYSACcharides BY USING A REDUCING AGENT FOR THE SULPHATING REACTION
EP0421508B1 (en) * 1989-10-04 1993-12-15 Akzo Nobel N.V. Sulphated glycosaminoglycuronan with antithrombotic activity
IT1237518B (en) * 1989-11-24 1993-06-08 Renato Conti SUPER-SULFATED HEPARINS
ITPD940054A1 (en) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl SULPHATED POLYSACCHARIDES
IT1306644B1 (en) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl THREE-DIMENSIONAL STRUCTURES INCLUDING HYALURONIC ACID DERIVATIVES OBTAINABLE THROUGH SUPERCRITICAL ANTI-SOLVENT TECHNIQUE.
CN103204950A (en) * 2013-04-23 2013-07-17 李苹苹 Method for purifying polysaccharide compound in mussel cooking juice
CN104497164A (en) * 2015-01-26 2015-04-08 吉林大学 High-voltage pulsed electric field assisted enzymolysis based clam polysaccharide extracting process
GB2579600B (en) 2018-12-05 2023-07-05 Byotrol Plc Anti-viral composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832766A (en) * 1952-04-17 1958-04-29 Univ Ohio State Res Found Sulfated aminopolysaccharides
GB740152A (en) * 1952-08-26 1955-11-09 Abbott Lab Sulfate esters of partially degraded chitin and salts thereof

Also Published As

Publication number Publication date
NO793474L (en) 1980-05-05
EP0011322B1 (en) 1982-05-05
PT70352A (en) 1979-11-01
FI793375A7 (en) 1981-01-01
ES485623A1 (en) 1980-05-16
AU5204579A (en) 1980-05-08
DE2962725D1 (en) 1982-06-24
DK459679A (en) 1980-05-02
JPS5564523A (en) 1980-05-15
SE7811306L (en) 1980-05-02
NZ191991A (en) 1982-05-25
ZA795596B (en) 1980-10-29
EP0011322A1 (en) 1980-05-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee