ATE95517T1 - Indanderivate, verfahren zu ihrer herstellung und erhaltene zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Indanderivate, verfahren zu ihrer herstellung und erhaltene zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE95517T1
Authority: AT; Austria
Prior art keywords: methyl; indanderivatives; manufacture; processes; pharmaceutical compositions
Prior art date: 1988-12-16

Application number

AT89403506T

Other languages

English (en)

Inventor

Francois Clemence

Michel Fortin

Gilles Hamon

Martret Odile Le

Anne-Marie Moura

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-16

Filing date

1989-12-15

Publication date

1993-10-15

1988-12-16 Priority claimed from FR888816605A external-priority patent/FR2640625B2/fr

1989-12-15 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1993-10-15 Application granted granted Critical

1993-10-15 Publication of ATE95517T1 publication Critical patent/ATE95517T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 4
-1 methyl-(2-phenylethyl)-amino Chemical group 0.000 abstract 3
CGFORRLIKRTSLT-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-methylacetamide Chemical group CNC(=O)CC1=CC=C(Cl)C(Cl)=C1 CGFORRLIKRTSLT-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
AOZUATNZXGQECR-UHFFFAOYSA-N n-methyl-2-(3-nitrophenyl)acetamide Chemical group CNC(=O)CC1=CC=CC([N+]([O-])=O)=C1 AOZUATNZXGQECR-UHFFFAOYSA-N 0.000 abstract 2
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
XKWULHLBNUUMKR-UHFFFAOYSA-N 3,5-ditert-butyl-4-hydroxy-n-methylbenzamide Chemical group CNC(=O)C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 XKWULHLBNUUMKR-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)

AT89403506T 1988-12-16 1989-12-15 Indanderivate, verfahren zu ihrer herstellung und erhaltene zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen. ATE95517T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR888816605A FR2640625B2 (fr)	1986-08-21	1988-12-16	Nouveaux composes optiquement actifs derives de l'indane, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP89403506A EP0374054B1 (de)	1988-12-16	1989-12-15	Indanderivate, Verfahren zu ihrer Herstellung und erhaltene Zwischenprodukte, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE95517T1 true ATE95517T1 (de)	1993-10-15

Family

ID=9373020

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89403506T ATE95517T1 (de)	1988-12-16	1989-12-15	Indanderivate, verfahren zu ihrer herstellung und erhaltene zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (13)

Country	Link
US (1)	US5436244A (de)
EP (1)	EP0374054B1 (de)
JP (1)	JP2753591B2 (de)
AT (1)	ATE95517T1 (de)
AU (1)	AU630136B2 (de)
BG (1)	BG61121B2 (de)
CA (1)	CA2005626A1 (de)
DE (1)	DE68909757T2 (de)
DK (1)	DK626889A (de)
ES (1)	ES2059805T3 (de)
HU (2)	HU219446B (de)
IE (1)	IE65151B1 (de)
ZA (1)	ZA899616B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5763445A (en)	1996-03-08	1998-06-09	Adolor Corporation	Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) *	1996-03-08	1997-07-08	Adolor Corporation	Kappa agonist compounds and pharmaceutical formulations thereof
DE19929076A1 (de)	1999-06-25	2000-12-28	Aventis Pharma Gmbh	Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
AU2016258192B2 (en)	2015-05-06	2021-07-29	Leidos Biomedical Research, Inc.	K-Ras modulators
GB201601301D0 (en) *	2016-01-25	2016-03-09	Takeda Pharmaceutical	Novel compounds
EP3612526A2 (de) *	2017-04-20	2020-02-26	The Regents of the University of California	K-ras-modulatoren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1109080A (en) *	1978-05-30	1981-09-15	Hideo Kato	Indanamine derivatives
US4359476A (en) *	1981-04-09	1982-11-16	The Upjohn Company	Adjacently substituted cycloalkane-amide analgesics
GB2096607B (en) *	1981-04-09	1985-02-27	Upjohn Co	Aminocycloalkyl amides
US4460600A (en) *	1981-04-09	1984-07-17	The Upjohn Company	Adjacently substituted ketal derivatives of cycloalkane-amide analgesics
US4360531A (en) *	1981-04-09	1982-11-23	The Upjohn Company	Substituted cycloalkanes
US4466977A (en) *	1981-04-09	1984-08-21	The Upjohn Company	N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics
DE3781627T2 (de) *	1986-08-21	1993-05-06	Roussel Uclaf	Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte.
US4876269A (en) *	1986-09-10	1989-10-24	E. I. Du Pont De Nemours And Company	Benoz-fused cycloalkane trans-1,2-diamine derivatives
FR2608598B1 (fr) *	1986-12-23	1989-04-14	Roussel Uclaf	Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant

1989
- 1989-12-12 DK DK626889A patent/DK626889A/da not_active Application Discontinuation
- 1989-12-14 JP JP1322788A patent/JP2753591B2/ja not_active Expired - Fee Related
- 1989-12-15 CA CA002005626A patent/CA2005626A1/fr not_active Abandoned
- 1989-12-15 ZA ZA899616A patent/ZA899616B/xx unknown
- 1989-12-15 EP EP89403506A patent/EP0374054B1/de not_active Expired - Lifetime
- 1989-12-15 HU HU631/89A patent/HU219446B/hu not_active IP Right Cessation
- 1989-12-15 ES ES89403506T patent/ES2059805T3/es not_active Expired - Lifetime
- 1989-12-15 IE IE402789A patent/IE65151B1/en not_active IP Right Cessation
- 1989-12-15 AT AT89403506T patent/ATE95517T1/de not_active IP Right Cessation
- 1989-12-15 AU AU46802/89A patent/AU630136B2/en not_active Ceased
- 1989-12-15 DE DE89403506T patent/DE68909757T2/de not_active Expired - Fee Related
1993
- 1993-07-22 US US08/096,034 patent/US5436244A/en not_active Expired - Fee Related
1994
- 1994-02-23 BG BG98525A patent/BG61121B2/bg unknown
1995
- 1995-06-30 HU HU95P/P00668P patent/HU211609A9/hu unknown

Also Published As

Publication number	Publication date
CA2005626A1 (fr)	1990-06-16
HU896631D0 (en)	1990-02-28
IE65151B1 (en)	1995-10-04
DE68909757T2 (de)	1994-03-31
HU211609A9 (en)	1995-12-28
JP2753591B2 (ja)	1998-05-20
JPH02218653A (ja)	1990-08-31
DK626889A (da)	1990-06-17
EP0374054A1 (de)	1990-06-20
IE894027L (en)	1990-06-16
BG61121B1 (bg)	1996-11-29
DK626889D0 (da)	1989-12-12
HUT53094A (en)	1990-09-28
EP0374054B1 (de)	1993-10-06
AU630136B2 (en)	1992-10-22
US5436244A (en)	1995-07-25
AU4680289A (en)	1990-06-21
ZA899616B (en)	1991-02-27
HU219446B (hu)	2001-04-28
ES2059805T3 (es)	1994-11-16
BG61121B2 (bg)	1996-11-29
DE68909757D1 (de)	1993-11-11

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Legal Events

Date	Code	Title	Description
1994-12-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee