ATE95692T1 - Phenol-thioalkylamide als inhibitoren von 5lipoxygenase. - Google Patents

Phenol-thioalkylamide als inhibitoren von 5lipoxygenase.

Info

Publication number
ATE95692T1
ATE95692T1 AT88108873T AT88108873T ATE95692T1 AT E95692 T1 ATE95692 T1 AT E95692T1 AT 88108873 T AT88108873 T AT 88108873T AT 88108873 T AT88108873 T AT 88108873T AT E95692 T1 ATE95692 T1 AT E95692T1
Authority
AT
Austria
Prior art keywords
thioalkylamides
inhibitors
phenol
lipoxygenase
allergy
Prior art date
Application number
AT88108873T
Other languages
English (en)
Inventor
Richard August Mueller
Richard Allen Partis
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE95692T1 publication Critical patent/ATE95692T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT88108873T 1987-06-05 1988-06-03 Phenol-thioalkylamide als inhibitoren von 5lipoxygenase. ATE95692T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/058,431 US4835189A (en) 1987-06-05 1987-06-05 Phenolic thioalkylamides as inhibitors of 5-lipoxygenase
EP88108873A EP0293899B1 (de) 1987-06-05 1988-06-03 Phenol-thioalkylamide als Inhibitoren von 5-Lipoxygenase

Publications (1)

Publication Number Publication Date
ATE95692T1 true ATE95692T1 (de) 1993-10-15

Family

ID=22016767

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88108873T ATE95692T1 (de) 1987-06-05 1988-06-03 Phenol-thioalkylamide als inhibitoren von 5lipoxygenase.

Country Status (7)

Country Link
US (1) US4835189A (de)
EP (1) EP0293899B1 (de)
JP (1) JPS63310820A (de)
AT (1) ATE95692T1 (de)
CA (1) CA1330446C (de)
DE (1) DE3884858T2 (de)
ES (1) ES2059438T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
DE3920616A1 (de) * 1989-06-23 1991-01-03 Boehringer Mannheim Gmbh Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate
DE4204405A1 (de) * 1991-08-02 1993-02-04 Boehringer Mannheim Gmbh Verwendung von di-tert.-butylhydroxyphenyl-derivaten zur therapie von entzuendlichen erkrankungen des magen-darm-traktes
US6737448B2 (en) * 2002-06-03 2004-05-18 Staar Surgical Company High refractive index, optically clear and soft hydrophobic acrylamide copolymers
SG175390A1 (en) 2009-04-29 2011-12-29 Amarin Corp Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
KR102249250B1 (ko) 2014-09-09 2021-05-07 스타 서지컬 컴퍼니 확장된 피사계 심도 및 향상된 원거리 시력의 안과용 임플란트
US12127934B2 (en) 2014-09-09 2024-10-29 Staar Surgical Company Method of Providing Modified Monovision to a Subject with a First Lens and a Second Lens
ES2912080T3 (es) 2016-03-09 2022-05-24 Staar Surgical Co Implantes oftálmicos con mayor profundidad de campo y agudeza visual mejorada a distancia
KR102560250B1 (ko) 2018-08-17 2023-07-27 스타 서지컬 컴퍼니 나노 구배의 굴절률을 나타내는 중합체 조성물
CN113200894A (zh) * 2020-03-16 2021-08-03 北京中美红格科技有限公司 双硫双丁酚及类似物的合成方法
CA3234381A1 (en) 2021-10-04 2023-04-13 Staar Surgical Company Ophthalmic implants for correcting vision with a tunable optic, and methods of manufacture and use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1064252A (en) * 1963-09-19 1967-04-05 Ici Ltd Amides and pharmaceutical compositions containing them
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
US3624143A (en) * 1968-05-10 1971-11-30 Merck & Co Inc Compounds of the class {62 -aralkylthio-substituted-{60 -amino acids
DE1936463A1 (de) * 1969-07-17 1971-02-04 Boehringer Sohn Ingelheim Substituierte Phenole
AT353776B (de) * 1973-12-27 1979-12-10 Siegfried Ag Verfahren zur herstellung von neuen alkan- saeuren, deren estern und salzen
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
JPS5758663A (en) * 1980-09-24 1982-04-08 Otsuka Pharmaceut Co Ltd Alkanoic acid derivative
DE3121072A1 (de) * 1981-05-27 1982-12-16 Henkel Kgaa "aryl- und heteroarylmercapto-alkansaeure-derivate als antiseborrhoische zusaetze fuer kosmetische mittel"
US4534874A (en) * 1983-11-21 1985-08-13 Ciba-Geigy Corporation Anti-oxidative, anti-thermal, and anti-actinic degradation amides of hydroxyphenylalkylthio alkanoic acids, compositions, and method of use therefor
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.
AU584669B2 (en) * 1985-02-04 1989-06-01 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
CA1332057C (en) * 1985-02-04 1994-09-20 Richard August Mueller Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides

Also Published As

Publication number Publication date
EP0293899B1 (de) 1993-10-13
ES2059438T3 (es) 1994-11-16
US4835189A (en) 1989-05-30
JPS63310820A (ja) 1988-12-19
CA1330446C (en) 1994-06-28
EP0293899A1 (de) 1988-12-07
DE3884858D1 (de) 1993-11-18
DE3884858T2 (de) 1994-03-03

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