ATE96671T1 - Verwendung von tetrahydrocortisol in der therapie von glaukom. - Google Patents

Verwendung von tetrahydrocortisol in der therapie von glaukom.

Info

Publication number: ATE96671T1
Authority: AT; Austria
Prior art keywords: tetrahydrocortisol; glaucoma; therapy; disclosed; control
Prior art date: 1986-05-19

Application number

AT87304317T

Other languages

English (en)

Inventor

Aaron Louis Southren

Bernard I Weinstein

Gary G Gordon

Original Assignee

New York Medical College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-19

Filing date

1987-05-15

Publication date

1993-11-15

1987-05-15 Application filed by New York Medical College filed Critical New York Medical College

1993-11-15 Application granted granted Critical

1993-11-15 Publication of ATE96671T1 publication Critical patent/ATE96671T1/de

Links

AODPIQQILQLWGS-UHFFFAOYSA-N (3alpa,5beta,11beta,17alphaOH)-form-3,11,17,21-Tetrahydroxypregnan-20-one, Natural products C1C(O)CCC2(C)C3C(O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC21 AODPIQQILQLWGS-UHFFFAOYSA-N 0.000 title abstract 2
AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 title abstract 2
208000010412 Glaucoma Diseases 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
230000004410 intraocular pressure Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Ophthalmology & Optometry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT87304317T 1986-05-19 1987-05-15 Verwendung von tetrahydrocortisol in der therapie von glaukom. ATE96671T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/864,610 US4863912A (en)	1986-05-19	1986-05-19	Use of tetrahydrocortisol in glaucoma therapy
EP87304317A EP0250088B1 (de)	1986-05-19	1987-05-15	Verwendung von Tetrahydrocortisol in der Therapie von Glaukom

Publications (1)

Publication Number	Publication Date
ATE96671T1 true ATE96671T1 (de)	1993-11-15

Family

ID=25343665

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87304317T ATE96671T1 (de)	1986-05-19	1987-05-15	Verwendung von tetrahydrocortisol in der therapie von glaukom.

Country Status (8)

Country	Link
US (1)	US4863912A (de)
EP (1)	EP0250088B1 (de)
JP (1)	JPH0725679B2 (de)
AT (1)	ATE96671T1 (de)
AU (1)	AU597660B2 (de)
CA (1)	CA1285878C (de)
DE (1)	DE3788004T2 (de)
ES (1)	ES2059375T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4997826A (en) *	1986-05-19	1991-03-05	New York Medical College	Tetrahydrocortisol in glaucoma therapy
US5358943A (en) *	1987-12-29	1994-10-25	Clark Abbot F	Use of tetrahydrocortisol to prevent elevations in intraocular pressure caused by corticosteroids
US5407926A (en) *	1987-12-29	1995-04-18	Alcon Laboratories, Inc.	Ophthalmic composition
US4876250A (en) *	1988-10-31	1989-10-24	Alcon Laboratories, Inc.	Methods for controlling ocular hypertension with angiostatic steroids
US4945089A (en) *	1987-12-29	1990-07-31	Alcon Laboratories, Inc.	Use of tetrahydrocortexolone to prevent elevations in intraocular pressure caused by corticosteroids
DE68900548D1 (de) *	1988-01-13	1992-01-30	Sanol Arznei Schwarz Gmbh	Konzentrierte corticosteroide enthaltende loesungen und verfahren zu deren herstellung.
US5990099A (en) *	1988-10-31	1999-11-23	Alcon Laboratories, Inc.	Angiostatic agents and methods and compositions for controlling ocular hypertension
US5371078A (en) *	1988-10-31	1994-12-06	Alcon Laboratories, Inc.	Angiostatic steroids and methods and compositions for controlling ocular hypertension
USRE34578E (en) *	1990-05-07	1994-04-05	Lubkin; Virginia	Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5041434A (en) *	1991-08-17	1991-08-20	Virginia Lubkin	Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
CA2111699A1 (fr) *	1991-06-18	1992-12-23	Gerard Schwadrohn	Compositions pharmaceutiques anti-glaucomateuses et leur procede d'obtention
FR2680108B1 (fr) *	1991-08-09	1993-11-19	Theramex Sa Laboratoire	Nouvelles compositions pharmaceutiques a base de sterouides 6-hydroxymethyles et leur procede d'obtention.
FR2679139B1 (fr) *	1991-07-17	1995-03-17	Theramex	Nouvelles compositions pharmaceutiques destinees a l'application oculaire renfermant un derive androstenique et leur procede de preparation.
CA2425841C (en) *	1991-11-22	2006-01-10	Alcon Laboratories, Inc.	Angiostatic steroids
ATE185697T1 (de) *	1992-04-21	1999-11-15	Schepens Eye Res Inst	Androgentherapie am auge beim sjögrensyndrom
US6107289A (en) *	1992-04-21	2000-08-22	The Schepens Eye Research Institute, Inc.	Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β
US5376534A (en) *	1993-12-17	1994-12-27	New York Medical College	Use of decreased 3-alpha-hydroxysteroid dehydrogenase activity in peripheral lymphocytes or other cells of patients with primary open angle glaucoma as a diagnostic indicator
US5798380A (en) *	1996-02-21	1998-08-25	Wisconsin Alumni Research Foundation	Cytoskeletal active agents for glaucoma therapy
US6586425B2 (en)	1996-02-21	2003-07-01	Wisconsin Alumni Research Foundation	Cytoskeletal active agents for glaucoma therapy
US5929111A (en) *	1996-12-18	1999-07-27	Alcon Laboratories, Inc.	A-seco steroids effective at treating ophthalmic pathological neovascularization and controlling intraocular pressure
US6011023A (en) *	1997-08-27	2000-01-04	Alcon Laboratories, Inc.	Angiostatic steroids
GB9914648D0 (en) *	1999-06-24	1999-08-25	Univ Birmingham	Control of infra-ocular pressure
US20050239760A1 (en) *	2004-04-23	2005-10-27	Alcon, Inc.	Angiostatic agents and methods and compositions for controlling ocular hypertension
US20080125406A1 (en) *	2005-10-14	2008-05-29	Robin Alan L	Method for Treating Primary and Secondary Forms of Glaucoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2783226A (en) *	1955-02-03	1957-02-26	Schering Corp	Esters of cortical hormones

1986
- 1986-05-19 US US06/864,610 patent/US4863912A/en not_active Expired - Fee Related
1987
- 1987-05-14 CA CA000537181A patent/CA1285878C/en not_active Expired - Lifetime
- 1987-05-15 ES ES87304317T patent/ES2059375T3/es not_active Expired - Lifetime
- 1987-05-15 AT AT87304317T patent/ATE96671T1/de not_active IP Right Cessation
- 1987-05-15 EP EP87304317A patent/EP0250088B1/de not_active Expired - Lifetime
- 1987-05-15 DE DE87304317T patent/DE3788004T2/de not_active Expired - Fee Related
- 1987-05-19 JP JP62122377A patent/JPH0725679B2/ja not_active Expired - Lifetime
- 1987-05-19 AU AU73173/87A patent/AU597660B2/en not_active Ceased

Also Published As

Publication number	Publication date
ES2059375T3 (es)	1994-11-16
DE3788004D1 (de)	1993-12-09
EP0250088B1 (de)	1993-11-03
JPS6322021A (ja)	1988-01-29
AU7317387A (en)	1987-11-26
AU597660B2 (en)	1990-06-07
JPH0725679B2 (ja)	1995-03-22
CA1285878C (en)	1991-07-09
EP0250088A2 (de)	1987-12-23
US4863912A (en)	1989-09-05
EP0250088A3 (en)	1990-03-28
DE3788004T2 (de)	1994-04-07

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Legal Events

Date	Code	Title	Description
1994-08-15	UEP	Publication of translation of european patent specification
1999-02-15	REN	Ceased due to non-payment of the annual fee