ATE97401T1 - Tricyclische verbindungen. - Google Patents

Tricyclische verbindungen.

Info

Publication number
ATE97401T1
ATE97401T1 AT88121224T AT88121224T ATE97401T1 AT E97401 T1 ATE97401 T1 AT E97401T1 AT 88121224 T AT88121224 T AT 88121224T AT 88121224 T AT88121224 T AT 88121224T AT E97401 T1 ATE97401 T1 AT E97401T1
Authority
AT
Austria
Prior art keywords
sub
sup
nitrogen
tricyclic compounds
amide
Prior art date
Application number
AT88121224T
Other languages
English (en)
Inventor
O William Lever Jr
Harry Jefferson Leighton
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10583945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE97401(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE97401T1 publication Critical patent/ATE97401T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT88121224T 1985-08-17 1986-08-15 Tricyclische verbindungen. ATE97401T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858520662A GB8520662D0 (en) 1985-08-17 1985-08-17 Tricyclic aromatic compounds
EP88121224A EP0316022B1 (de) 1985-08-17 1986-08-15 Tricyclische Verbindungen

Publications (1)

Publication Number Publication Date
ATE97401T1 true ATE97401T1 (de) 1993-12-15

Family

ID=10583945

Family Applications (3)

Application Number Title Priority Date Filing Date
AT88121224T ATE97401T1 (de) 1985-08-17 1986-08-15 Tricyclische verbindungen.
AT86306326T ATE51867T1 (de) 1985-08-17 1986-08-15 Tricyclische verbindungen.
AT89115497T ATE125535T1 (de) 1985-08-17 1986-08-15 Tricyclische aromatische verbindungen.

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT86306326T ATE51867T1 (de) 1985-08-17 1986-08-15 Tricyclische verbindungen.
AT89115497T ATE125535T1 (de) 1985-08-17 1986-08-15 Tricyclische aromatische verbindungen.

Country Status (13)

Country Link
US (1) US4871865A (de)
EP (3) EP0351887B1 (de)
JP (2) JPH0739346B2 (de)
AT (3) ATE97401T1 (de)
DE (3) DE3689311T2 (de)
ES (1) ES2001519A6 (de)
GB (1) GB8520662D0 (de)
GR (1) GR862137B (de)
HK (1) HK97593A (de)
HU (1) HU201520B (de)
IL (1) IL79729A (de)
PT (1) PT83202B (de)
SG (1) SG38393G (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6310784A (ja) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
JPH07116174B2 (ja) * 1987-02-27 1995-12-13 協和醗酵工業株式会社 ジベンズ〔ｂ，ｅ〕オキセピン誘導体
AU605501B2 (en) * 1987-08-25 1991-01-17 Kyowa Hakko Kirin Co., Ltd. Dibenz(b,e)oxepin derivative and antiallergic agent
US4882351A (en) * 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
AU612437B2 (en) * 1987-12-14 1991-07-11 Kyowa Hakko Kogyo Co. Ltd. Tricyclic compounds
US5242931A (en) * 1988-06-09 1993-09-07 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds as TXA2 antagonists
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5208238A (en) * 1989-06-19 1993-05-04 Burroughs Wellcome Company Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
IL94768A (en) * 1989-06-19 1995-08-31 Wellcome Found Use of aryl-substituted amine derivatives in the preparation of pharmaceutical compositions
GB8914061D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
GB8914060D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
GB8914040D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
EP0522460A3 (en) * 1991-07-09 1993-03-24 Sumitomo Electric Industries, Ltd. Semiconductor device testing apparatus
US5641805A (en) * 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
US5899727A (en) 1996-05-02 1999-05-04 Advanced Micro Devices, Inc. Method of making a semiconductor isolation region bounded by a trench and covered with an oxide to improve planarization
DE19848200A1 (de) * 1998-10-20 2000-04-27 Basf Ag Verfahren zur Trocknung von Phenoxymethylbenzoesäuren
US6174914B1 (en) 1999-06-15 2001-01-16 Alcon Laboratories, Inc. Method of inhibiting cytokine release from human ocular cells
EP1187617B1 (de) 1999-06-18 2004-03-03 Alcon Manufacturing Ltd. Methode zur konzentrationsbestimmung einer amphipathischen antihistaminischen verbindung durch bestimmung ihrer oberflächen aktivitäts einstufung
US6174878B1 (en) 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
US20040097486A1 (en) * 1999-11-18 2004-05-20 Yanni John M. Use of an H1 antagonist and a safe steroid to treat eye conditions
US6375973B2 (en) 2000-01-25 2002-04-23 Alcon Universal Ltd. Ophthalmic anti-allergy compositions suitable for use with contact lenses
AU5722701A (en) 2000-05-19 2001-12-03 Alcon Universal Ltd Aniline disulfide derivatives for treating allergic diseases
JP2003534274A (ja) 2000-05-19 2003-11-18 アルコン，インコーポレイテッド アレルギー性疾患を処置するための、ベンズアミドジスルフィド誘導体を含む組成物
DK1282599T3 (da) 2000-05-19 2006-07-31 Alcon Inc Disulfidderivater, der er egnede til behandling af allergiske sygdomme
US7977376B2 (en) 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
TWI231759B (en) 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
KR20050044550A (ko) * 2001-12-05 2005-05-12 알콘, 인코퍼레이티드 비염 치료를 위한 η1 길항제 및 안전한 스테로이드제의용도
US20050209312A1 (en) * 2004-03-19 2005-09-22 Bausch & Lomb Incorporated Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative
BRPI0512732A (pt) * 2004-06-28 2008-04-08 Alcon Inc formulações tópicas para tratamento de doenças alérgicas
ES2253996B1 (es) * 2004-07-28 2007-08-16 Urquima, S.A. Procedimiento para la preparacion del acido 11-((z)-3-(dimetilamino)propiliden)-6,11-dihidrodibenz(b,e)oxepinacetico.
MX2007005845A (es) * 2004-11-24 2007-07-04 Alcon Inc Metodo para entregar rocio nasal.
CA2634665A1 (en) 2005-12-22 2007-10-25 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation
US7950020B2 (en) * 2006-03-16 2011-05-24 Ntt Docomo, Inc. Secure operating system switching
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
US8445437B2 (en) * 2006-07-27 2013-05-21 The Brigham And Women's Hospital, Inc. Treatment and prevention of cardiovascular disease using mast cell stabilizers
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
PT2114367E (pt) 2007-02-07 2016-02-01 Novartis Ag Formulações de olopatadina para administração nasal tópica
WO2008099900A1 (ja) * 2007-02-16 2008-08-21 Sumitomo Chemical Company, Limited ジベンゾオキセピン化合物の製造方法
KR20100014565A (ko) * 2007-04-11 2010-02-10 알콘 리서치, 리미티드 알레르기성 비염 및 알레르기성 결막염을 치료하기 위한 ｔｎｆａ의 억제제 및 항히스타민의 용도
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CN101808642B (zh) 2007-09-28 2012-05-02 布里格海姆妇女医院公司 肥大细胞稳定剂治疗肥胖症
CA2718891C (en) * 2008-03-20 2016-10-18 Lek Pharmaceuticals D.D. 2'-halobiphenyl-4-yl intermediates in the synthesis of angiotensin ii antagonists
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
EP2666770A1 (de) 2008-07-16 2013-11-27 Crystal Pharma S.A.U Verfahren zur Herstellung von Olopatadin und Zwischenprodukten
WO2010089268A2 (en) * 2009-02-05 2010-08-12 Zach System S.P.A. Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof
IT1397503B1 (it) 2009-04-21 2013-01-16 F S I Fabbrica Italiana Sint Processo per la preparazione di olopatadina
PL2453872T3 (pl) 2009-07-17 2013-12-31 Alcon Res Ltd Olopatadyna w postaci spreju do donosowego podawania dzieciom
WO2011027322A1 (en) 2009-09-03 2011-03-10 Ranbaxy Laboratories Limited Extended release dosage form containing olopatadine for oral administration
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
WO2014025370A1 (en) 2012-08-10 2014-02-13 Hallstar Innovations Corp. Tricyclic energy quencher compounds for reducing singlet oxygen generation
US9145383B2 (en) 2012-08-10 2015-09-29 Hallstar Innovations Corp. Compositions, apparatus, systems, and methods for resolving electronic excited states
US9937189B2 (en) 2013-09-13 2018-04-10 Glenmark Specialty S.A. Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine
MX367674B (es) 2013-09-13 2019-08-30 Glenmark Specialty Sa Composición farmacéutica de dosis fija estable que comprende mometasona y olopatadina.
US9370483B2 (en) 2013-09-13 2016-06-21 Glenmark Specialty S.A. Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine
US10016443B2 (en) 2013-10-04 2018-07-10 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10548907B2 (en) 2013-10-04 2020-02-04 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10758550B2 (en) 2013-10-04 2020-09-01 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10653661B2 (en) 2013-10-04 2020-05-19 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
CN105792828A (zh) 2013-10-04 2016-07-20 格兰马克药品有限公司 使用莫米松和奥洛他定的组合治疗过敏性鼻炎
ES2792682T3 (es) 2014-02-10 2020-11-11 Respivant Sciences Gmbh Métodos para el tratamiento de enfermedades pulmonares con estabilizadores de mastocitos
PL3104853T3 (pl) 2014-02-10 2020-05-18 Respivant Sciences Gmbh Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych
US11679210B2 (en) 2014-10-03 2023-06-20 Glenmark Specialty S.A. Dispensing device and pharmaceutical composition for the treatment of rhinitis
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10238625B2 (en) 2015-08-07 2019-03-26 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
WO2018044942A1 (en) 2016-08-31 2018-03-08 Patara Pharma, LLC Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
EP3522983A4 (de) 2016-10-07 2020-06-03 Respivant Sciences GmbH Cromolynzusammensetzung zur behandlung von lungenfibrose
HUE071622T2 (hu) 2018-02-23 2025-09-28 Glenmark Specialty Sa Allergiás Rhinitis kezelése gyermekgyógyászati alanyoknál mometazon és olopatadin kombinációjával
US12303635B2 (en) 2018-04-16 2025-05-20 Glenmark Specialty S.A. Dispensing device and pharmaceutical composition for the treatment of rhinitis
WO2021094296A1 (en) 2019-11-12 2021-05-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of mast cell stabilizer for the treatment of heart failure with preserved ejection fraction
US20240374555A1 (en) * 2023-04-10 2024-11-14 Magi's Lab Srl Mast Cell Stabilizer with Sodium Cromoglycate-based Inhibitor for Preventing Lipedema Progression

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL58901C (de) * 1957-02-07 1947-02-15
DE1232161B (de) * 1961-10-07 1967-01-12 Boehringer & Soehne Gmbh Verfahren zur Herstellung von basisch substituierten Dibenzo-oxepinen und deren Salzen
BE641498A (de) * 1962-03-13
US3401192A (en) * 1962-07-17 1968-09-10 Merck & Co Inc Esters of 5h-dibenzo [a, d] cycloheptene
US3420851A (en) * 1962-12-19 1969-01-07 Pfizer & Co C Novel dibenzoxepines
US3509175A (en) * 1963-10-14 1970-04-28 Pfizer & Co C Recovery of pure cis 11-(3-dimethylaminopropylidene) - 6,11 - dihydrodibenz(b,e)oxepine from admixture with its trans isomer
GB1076612A (en) * 1964-07-24 1967-07-19 Merck & Co Inc Dibenzocycloheptene derivatives
FR2138257B1 (de) * 1971-05-21 1974-08-23 Roussel Uclaf
OA04603A (fr) * 1973-03-02 1980-06-30 Rhone Poulenc Sa Nouveaux dérivés du dibenzo [a,d] cycloheptene, leurs sels et leur préparation.
US3966820A (en) * 1974-07-05 1976-06-29 Syntex (U.S.A.) Inc. 2-Substituted-5-oxo-5H-dibenzo-[A,D]cycloheptenes, the esters and ethers thereof, having pharmaceutical activity, and methods and compositions for the use thereof
JPS5139683A (ja) * 1974-10-02 1976-04-02 Dai Ichi Kogyo Seiyaku Co Ltd Jibenzookisebinjudotaino seizoho
JPS5516590A (en) * 1978-07-21 1980-02-05 Nec Corp Television relay broadcasting equipment
US4282365A (en) * 1978-11-24 1981-08-04 Merck & Co., Inc. Dibenz[b,e]oxepin compounds
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
US4307245A (en) * 1978-12-29 1981-12-22 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
JPS56156273A (en) * 1980-03-31 1981-12-02 Dainippon Pharmaceut Co Ltd Acetic derivative
US4412999A (en) * 1982-04-14 1983-11-01 Merck & Co., Inc. Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
JPS6028972A (ja) * 1983-06-29 1985-02-14 Kyowa Hakko Kogyo Co Ltd ジベンゾ［ｂ，ｅ］オキセピン誘導体

Also Published As

Publication number Publication date
EP0351887B1 (de) 1995-07-26
JPH07165749A (ja) 1995-06-27
EP0214779A1 (de) 1987-03-18
US4871865A (en) 1989-10-03
JPH0739346B2 (ja) 1995-05-01
EP0214779B1 (de) 1990-04-11
HK97593A (en) 1993-09-24
DE3670290D1 (de) 1990-05-17
IL79729A (en) 1990-11-05
DE3650357D1 (de) 1995-08-31
SG38393G (en) 1993-06-11
EP0316022A2 (de) 1989-05-17
DE3689311T2 (de) 1994-03-10
EP0351887A1 (de) 1990-01-24
HUT41761A (en) 1987-05-28
JP2556821B2 (ja) 1996-11-27
DE3689311D1 (de) 1993-12-23
GR862137B (en) 1986-12-30
PT83202B (pt) 1989-03-30
GB8520662D0 (en) 1985-09-25
IL79729A0 (en) 1986-11-30
PT83202A (en) 1986-09-01
EP0316022B1 (de) 1993-11-18
ATE125535T1 (de) 1995-08-15
ATE51867T1 (de) 1990-04-15
HU201520B (en) 1990-11-28
JPS6245557A (ja) 1987-02-27
EP0316022A3 (en) 1989-10-11
ES2001519A6 (es) 1988-06-01
DE3650357T2 (de) 1996-01-04

Similar Documents

Publication Publication Date Title
ATE97401T1 (de) Tricyclische verbindungen.
DK126389D0 (da) Peptidforbindelser
ES8500233A1 (es) Un metodo para preparar compuestos de piridilo
GB1425606A (en) Cyclohexenone derivatives
ES8506675A1 (es) Un metodo para preparar derivados de fenotiazina
GB1465769A (en) Carbamates of ergolines
GB1449078A (en) Phenoxyethylamine derivatives
ES556048A0 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
AU586089B2 (en) Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure
ES8600762A1 (es) Un procedimiento para la preparacion de nuevos compuestos de beta-lactama.
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
GB1127170A (en) New tricyclic amines, the preparation and compositions containing same
NZ222973A (en) Substituted piperidine and azepine derivatives and pharmaceutical compositions
TH17758A (th) สารเคมี

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time