ATE97664T1 - Isoxazole und isoxazolin-derivate mit antikonvulsiva und pharmazeutische zusammensetzungen, die sie enthalten. - Google Patents

Isoxazole und isoxazolin-derivate mit antikonvulsiva und pharmazeutische zusammensetzungen, die sie enthalten.

Info

Publication number
ATE97664T1
ATE97664T1 AT89403300T AT89403300T ATE97664T1 AT E97664 T1 ATE97664 T1 AT E97664T1 AT 89403300 T AT89403300 T AT 89403300T AT 89403300 T AT89403300 T AT 89403300T AT E97664 T1 ATE97664 T1 AT E97664T1
Authority
AT
Austria
Prior art keywords
group
anticonvulsants
isoxazole
pharmaceutical compositions
hydrogen atom
Prior art date
Application number
AT89403300T
Other languages
English (en)
Inventor
Francis Lepage
Bernard Hublot
Original Assignee
Novapharme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novapharme filed Critical Novapharme
Application granted granted Critical
Publication of ATE97664T1 publication Critical patent/ATE97664T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT89403300T 1988-11-30 1989-11-28 Isoxazole und isoxazolin-derivate mit antikonvulsiva und pharmazeutische zusammensetzungen, die sie enthalten. ATE97664T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR888815718A FR2639636B1 (fr) 1988-11-30 1988-11-30 Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant
EP89403300A EP0371876B1 (de) 1988-11-30 1989-11-28 Isoxazole und Isoxazolin-Derivate mit Antikonvulsiva und pharmazeutische Zusammensetzungen, die sie enthalten

Publications (1)

Publication Number Publication Date
ATE97664T1 true ATE97664T1 (de) 1993-12-15

Family

ID=9372456

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89403300T ATE97664T1 (de) 1988-11-30 1989-11-28 Isoxazole und isoxazolin-derivate mit antikonvulsiva und pharmazeutische zusammensetzungen, die sie enthalten.

Country Status (5)

Country Link
US (1) US5059614A (de)
EP (1) EP0371876B1 (de)
AT (1) ATE97664T1 (de)
DE (1) DE68910945T2 (de)
FR (1) FR2639636B1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258397A (en) * 1988-11-30 1993-11-02 Novapharme 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions
FR2662692B1 (fr) * 1990-05-30 1995-04-28 Novapharme Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique.
US5656573A (en) * 1989-09-11 1997-08-12 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazoles
US5747424A (en) * 1989-09-11 1998-05-05 Rhone-Poulenc Agriculture Ltd. Herbicidal 4-substituted isoxazol
US5650533A (en) * 1989-09-11 1997-07-22 Rhone-Poulenc Agriculture Ltd. Intermediates to herbicidal 4-substituted isoxazoles
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
PL314605A1 (en) * 1993-11-26 1996-09-16 Pfizer Isoxazolin compounds as anti-inflammatory agents
CA2185019C (en) * 1994-03-09 2000-08-08 Pfizer Limited Isoxazoline compounds as inhibitors of tnf release
EP0749307A1 (de) * 1994-03-09 1996-12-27 Pfizer Inc. Isoxazolin-verbindungen als 5-lipoxygenase-hemmer
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
FR2750425B1 (fr) * 1996-07-01 1998-08-28 Novapharme Preparation de derives de 3-amino-isoxazole et nouveaux 3-amino-isoxazoles intermediaires
GB9706730D0 (en) * 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
EP1047418B1 (de) * 1997-12-22 2005-07-27 Bayer Pharmaceuticals Corp. Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen
AU2006201959B2 (en) * 1997-12-22 2008-09-04 Bayer Healthcare Llc Inhibition of Raf Kinase using Substituted Heterocyclic Ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (de) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren
RU2319693C9 (ru) 1999-01-13 2008-08-20 Байер Копэрейшн Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
MXPA02002578A (es) 1999-09-08 2002-10-23 Guilford Pharm Inc Compuestos de union a ciclofilina no peptidicos, y su uso.
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1360173A2 (de) 2001-01-25 2003-11-12 Guilford Pharmaceuticals Inc. Trisubstituierte karbozyklische zyklophilin bindende verbindungen und deren verwendung
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
US20030216396A1 (en) 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
PT1580188E (pt) 2002-02-11 2012-01-25 Bayer Healthcare Llc Aril-ureias como inibidores de cinases
US20040023961A1 (en) * 2002-02-11 2004-02-05 Bayer Corporation Aryl ureas with raf kinase and angiogenisis inhibiting activity
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
US20030236287A1 (en) * 2002-05-03 2003-12-25 Piotrowski David W. Positive allosteric modulators of the nicotinic acetylcholine receptor
US6727272B1 (en) * 2002-07-15 2004-04-27 Unitech Pharmaceuticals, Inc. Leflunomide analogs for treating rheumatoid arthritis
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
RS52625B (sr) 2003-07-23 2013-06-28 Bayer Healthcare Llc Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti
ATE517885T1 (de) * 2004-04-30 2011-08-15 Bayer Healthcare Llc Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs
US7825278B2 (en) 2004-05-06 2010-11-02 The Regents Of The University Of California Substituted enaminones, their derivatives and uses thereof
EP1794130A1 (de) * 2004-09-20 2007-06-13 Biolipox AB Pyrazolverbindungen die in der behandlung von entzündungen nützlich sind
JP2008513426A (ja) * 2004-09-20 2008-05-01 バイオリポックス エービー 炎症の治療に有用なピラゾール化合物
US7291743B2 (en) * 2005-03-29 2007-11-06 Geneblue Corporation Isoxazole derivatives and methods of treating nitric oxide mediated diseases
TW200800911A (en) * 2005-10-20 2008-01-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
EA200801108A1 (ru) * 2005-10-31 2008-10-30 Биолипокс Аб Триазолы, пригодные для лечения воспалений
TW200732320A (en) * 2005-10-31 2007-09-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
JP2009513692A (ja) * 2005-11-01 2009-04-02 バイオリポックス エービー 炎症の治療に有用なピラゾール化合物
US20080085912A1 (en) * 2006-10-06 2008-04-10 Unitech Pharmaceuticals, Inc. Isoxazole derivatives and methods of treating diseases
CA2833493C (en) 2011-04-28 2020-06-02 Japan Tobacco Inc. Amide compound and pharmaceutical application therefor
US10443044B2 (en) 2014-04-17 2019-10-15 Ips Heart Generating cardiac progenitor cells from pluripotent stem cells using isoxazole or isoxazole like compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2126329A (en) * 1936-03-20 1938-08-09 Hoffmann La Roche Amide derivatives of isoxazole carboxylic acids
US3547940A (en) * 1967-10-31 1970-12-15 Du Pont Substituted ureido isoxazoles
FR2073284B1 (de) * 1969-12-23 1973-07-13 Ferlux
SE366993B (de) * 1970-09-11 1974-05-13 Thomae Gmbh Dr K
US4062861A (en) * 1973-07-27 1977-12-13 Shionogi & Co., Ltd. 3-Isoxazolylurea derivatives
JPS52264A (en) * 1975-06-21 1977-01-05 Kyorin Pharmaceut Co Ltd Process for preparing novel isoxazole derivatives
MA19269A1 (fr) * 1980-09-16 1982-04-01 Lilly Co Eli Perfectionnement relatif a des derives de n-arylbenzamides .
US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides

Also Published As

Publication number Publication date
DE68910945D1 (de) 1994-01-05
US5059614A (en) 1991-10-22
EP0371876B1 (de) 1993-11-24
EP0371876A1 (de) 1990-06-06
DE68910945T2 (de) 1994-05-19
FR2639636A1 (fr) 1990-06-01
FR2639636B1 (fr) 1994-03-04

Similar Documents

Publication Publication Date Title
ATE97664T1 (de) Isoxazole und isoxazolin-derivate mit antikonvulsiva und pharmazeutische zusammensetzungen, die sie enthalten.
DK0494819T3 (da) Hidtil ukendte phenylimidazolidiner, deres fremstilling, anvendelse som lægemidler samt farmaceutiske præparater med indhold heraf
HUP9901096A2 (hu) Indolszármazékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
DE69214755D1 (de) Thiazolidin-2,4-Dionderivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
ATE50256T1 (de) Hypoglycemische thiazolidinedione.
ATE87620T1 (de) Heterocyclische verbindungen.
ATE5967T1 (de) 3,4-diarylisoxazol-5-essigsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
ATE170530T1 (de) Thiazolidinderivate, ihre herstellung und medikamente, die sie enthalten
HUP9801356A2 (hu) Triciklusos (2-hidroxi-2-metil-3,3,3-trifluor-propanoil)-amino-benzoxepin-, -benzotiepin-, -benzocikloheptén-, -indén-származékok és az ezeket tartalmazó gyógyszerkészítmények
MX9203417A (es) Compuestos de diarilo antiateroescleroticos.
ES2091310T3 (es) Nuevos derivados de la n-benzoil-prolina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
FI894134A0 (fi) Disubstituerade bensylaminer, deras framstaellningsprocess, deras anvaendning som medicin och deras framstaellningsaemnen.
DE69004815D1 (de) 1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen.
AU553924B2 (en) 1-aryl 2-aminomethyl cyclopropane carboxylates
ATE102199T1 (de) 4-amino-3-carboxynaphthyridin-derivate, ihre herstellung und pharmazeutische zusammensetzungen.
ATE11915T1 (de) Benzothiazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung.
DE59102245D1 (de) N-Phenyl-piperidyl-4-amine und diese enthaltende Arzneimittel.
ATE80384T1 (de) Sulfurierte eicosanoide und deren verwendung in arzneimitteln und kosmetika.
DK461687A (da) Benzhydryloxyethylpiperidinderivater og salte deraf samt deres fremstilling og anvendelse.
ES8103081A1 (es) Procedimiento para la obtencion de diazatriciclos
IL59052A (en) Hexahydro-1,4-oxazepine derivatives,their preparation and pharmaceutical compositions containing them
DK73289D0 (da) Basisk substituerede 5-halogen-thienoisothiazol-3(2h)-on-1,1-dioxider, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse
SE7908439L (sv) Nya beta-laktonderivat av 2-hydroxicyklopentankarboxylsyra, sett for framstellning och anvendning derav som lekemedel samt farmaceutiska kompositioner innehallande dessa foreningar
ATE10001T1 (de) Thiovinyl-3-cephalosporinverbindungen, ihre herstellung und sie enthaltende pharmazeutische praeparate.
NO305439B1 (no) Pyrido(1,2,3-de)kinoksalinderivater og legemidler inneholdende disse

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties