ATE98227T1 - Di-tert-butyl-hydroxyphenylthioderivate, deren herstellung und verwendung. - Google Patents

Di-tert-butyl-hydroxyphenylthioderivate, deren herstellung und verwendung.

Info

Publication number
ATE98227T1
ATE98227T1 AT90300764T AT90300764T ATE98227T1 AT E98227 T1 ATE98227 T1 AT E98227T1 AT 90300764 T AT90300764 T AT 90300764T AT 90300764 T AT90300764 T AT 90300764T AT E98227 T1 ATE98227 T1 AT E98227T1
Authority
AT
Austria
Prior art keywords
tert
thioderivates
preparation
butyl hydroxyphenyl
hydroxyphenyl
Prior art date
Application number
AT90300764T
Other languages
English (en)
Inventor
Toru Kita
Masayuki Narasada
Shuh Narumiya
Marutamachisagur Kokamachidori
Fumihiko Watanabe
Masami Doteuchi
Takuji Mizui
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE98227T1 publication Critical patent/ATE98227T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/22—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT90300764T 1989-01-25 1990-01-24 Di-tert-butyl-hydroxyphenylthioderivate, deren herstellung und verwendung. ATE98227T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1015387A JP2627003B2 (ja) 1989-01-25 1989-01-25 ジーｔｅｒｔ―ブチルヒドロキシフェニルチオ誘導体

Publications (1)

Publication Number Publication Date
ATE98227T1 true ATE98227T1 (de) 1993-12-15

Family

ID=11887332

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90300764T ATE98227T1 (de) 1989-01-25 1990-01-24 Di-tert-butyl-hydroxyphenylthioderivate, deren herstellung und verwendung.

Country Status (7)

Country Link
US (1) US4954514A (de)
EP (1) EP0380331B1 (de)
JP (1) JP2627003B2 (de)
KR (1) KR900011754A (de)
AT (1) ATE98227T1 (de)
DE (1) DE69004984T2 (de)
DK (1) DK0380331T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US5192791A (en) * 1988-09-26 1993-03-09 Biofor, Ltd. Fused ring heterocycles and pharmaceutical compositions containing same
CA2118706A1 (en) * 1992-07-13 1994-01-20 Saizo Shibata Novel thiazolidinedione compounds and use thereof
US5326907A (en) * 1992-12-18 1994-07-05 G. D. Searle & Co. 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers
JP4456183B2 (ja) * 1997-01-22 2010-04-28 アベンテイス・フアーマシユーチカルズ・インコーポレーテツド 置換β−チオカルボン酸類
CA2292388C (en) 1997-05-14 2004-07-20 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
JP2002511878A (ja) * 1997-07-01 2002-04-16 アセロジエニクス・インコーポレイテツド 抗酸化剤による過増殖状態の治療の増強
EP1127882A1 (de) 2000-01-25 2001-08-29 Pfizer Products Inc. Tetrazolverbindungen als Thyroid-Rezeptor-Liganden
EP1385501A2 (de) * 2001-04-11 2004-02-04 Atherogenics, Inc. Probucol-monoesters und ihre verwendung zur erhöhung des hdl-plasmaspiegels und zur verbesserung der hdl-funktionalität
US20030153536A1 (en) * 2001-10-25 2003-08-14 Mitchell Glass Compounds and methods of treating transplant rejection
US20030181520A1 (en) * 2001-11-09 2003-09-25 Mitchell Glass Methods of reversing and preventing cardiovascular pathologies
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders
CN103896815B (zh) * 2014-03-26 2016-03-30 安徽师范大学 一种邻位巯基苯酚衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337576A (en) * 1966-01-20 1967-08-22 Bristol Myers Co Arylthioalkyltetrazoles
DE1936463A1 (de) * 1969-07-17 1971-02-04 Boehringer Sohn Ingelheim Substituierte Phenole
CA1037964A (en) * 1973-02-14 1978-09-05 Eugene R. Wagner 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
AU584669B2 (en) * 1985-02-04 1989-06-01 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Also Published As

Publication number Publication date
DE69004984D1 (de) 1994-01-20
EP0380331B1 (de) 1993-12-08
DE69004984T2 (de) 1994-04-07
JPH02196770A (ja) 1990-08-03
US4954514A (en) 1990-09-04
JP2627003B2 (ja) 1997-07-02
EP0380331A1 (de) 1990-08-01
DK0380331T3 (da) 1994-02-14
KR900011754A (ko) 1990-08-02

Similar Documents

Publication Publication Date Title
ATE98227T1 (de) Di-tert-butyl-hydroxyphenylthioderivate, deren herstellung und verwendung.
FI925100A0 (fi) Substituerade bifenylpyridoner
RU94036004A (ru) Промежуточные соединения для получения ароматических аминоспиртовых производных
DE59009351D1 (de) Neue arylpyridazine, ihre herstellung, verwendung und sie enthaltende arzneimittel.
ATE50763T1 (de) Tetralin-derivate, ihre herstellung und verwendung.
EE03264B1 (et) Peptiidi derivaadid, nende saamise protsess, neid sisaldavad ravimpreparaadid ja nende kasutamine
LU91223I2 (fr) Ivabradine et ses dérivés pharmaceutiquement acceptables (procoralan)
ES2141744T3 (es) Azaquinoxalinas, procedimiento para su preparacion y su empleo.
ATE188965T1 (de) Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
DK0530505T3 (da) Hydantoinderivater
ATE212860T1 (de) Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
DE59208974D1 (de) Neue pyrazinderivative, ihre herstellung und verwendung
ES2063097T3 (es) Inhibidor de la glicosidasa salbostatina, procedimiento para su preparacion y su empleo.
ATE53837T1 (de) Pyridin-derivate, ihre herstellung und verwendung.
ATE53377T1 (de) 1-substituierte tetralinderivate, ihre herstellung und verwendung.
DE59001281D1 (de) Oxidierte diphenylheteroalkane, ihre herstellung und verwendung.
DE58905079D1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.
AU8383691A (en) Amelinic compounds and use thereof in self-extinguishing polymeric compositions
DE69302087D1 (de) Trazodone alkyl derivate mit zns wirkung
IL89628A0 (en) Guanidinium compounds and their use as fungicides
PT97663A (pt) Processo de preparacao de 3'-desamino-4'-desoxi-4'-amino-8-fluoro-antraciclinas, de composicoes farmaceuticas que as contem e de seus intermediarios
DE69407042D1 (de) Psoralen-derivate, deren herstellung und verwendung als arzneimittel
ES8703847A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinopirimidina
DE59003446D1 (de) 13-Brom und 13, 14-Dibrom-Ergoline, ihre Herstellung und Verwendung in Arzneimitteln.
ATE72433T1 (de) Aether und thioaether mit heilender wirkung, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee