ATE98257T1 - Methode zur reinigung von interferon. - Google Patents

Methode zur reinigung von interferon.

Info

Publication number: ATE98257T1
Authority: AT; Austria
Prior art keywords: interferon; aqueous solution; column; crude; pyrogenic
Prior art date: 1987-07-31

Application number

AT88111201T

Other languages

English (en)

Inventor

Otello Protasi

Paolo Rappuoli

Original Assignee

Sclavo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-31

Filing date

1988-07-13

Publication date

1993-12-15

1988-07-13 Application filed by Sclavo Spa filed Critical Sclavo Spa

1993-12-15 Application granted granted Critical

1993-12-15 Publication of ATE98257T1 publication Critical patent/ATE98257T1/de

Links

102000014150 Interferons Human genes 0.000 title abstract 8
108010050904 Interferons Proteins 0.000 title abstract 8
229940079322 interferon Drugs 0.000 title abstract 8
238000000034 method Methods 0.000 title abstract 3
239000007864 aqueous solution Substances 0.000 abstract 4
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
239000008367 deionised water Substances 0.000 abstract 2
238000010828 elution Methods 0.000 abstract 2
230000001698 pyrogenic effect Effects 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
230000002378 acidificating effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000004108 freeze drying Methods 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
238000001179 sorption measurement Methods 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT88111201T 1987-07-31 1988-07-13 Methode zur reinigung von interferon. ATE98257T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT21560/87A IT1222427B (it)	1987-07-31	1987-07-31	Procedimento per la purificazione di interferone
EP88111201A EP0301314B1 (de)	1987-07-31	1988-07-13	Methode zur Reinigung von Interferon

Publications (1)

Publication Number	Publication Date
ATE98257T1 true ATE98257T1 (de)	1993-12-15

Family

ID=11183608

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88111201T ATE98257T1 (de)	1987-07-31	1988-07-13	Methode zur reinigung von interferon.

Country Status (6)

Country	Link
US (1)	US5066786A (de)
EP (1)	EP0301314B1 (de)
AT (1)	ATE98257T1 (de)
DE (1)	DE3886118T2 (de)
ES (1)	ES2046999T3 (de)
IT (1)	IT1222427B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1240612B (it) *	1990-03-16	1993-12-17	Sclavo Spa	Procedimento di purificazione del b-interferone umano ricombinante
EP0551535A1 (de) *	1992-01-13	1993-07-21	SCLAVO S.p.A.	Verfahren zur Reinigung von rekombinant-menschlichem Interferon-Beta, dadurch gereinigtes Interferon-Beta und pharmazeutische Zusammensetzungen, die diese enthalten
EP0626448A3 (de) *	1993-05-26	1998-01-14	BOEHRINGER INGELHEIM INTERNATIONAL GmbH	Verfahren zur Herstellung und Reinigung von alpha-Interferon
WO2002038170A2 (en) *	2000-11-07	2002-05-16	Chiron Corporation	Stabilized inteferon compositions
KR100524871B1 (ko) *	2003-12-04	2005-10-31	씨제이 주식회사	인터페론 베타의 정제방법
KR100524872B1 (ko) *	2003-12-04	2005-11-01	씨제이 주식회사	인터페론 베타의 정제방법
US8778880B2 (en)	2004-02-02	2014-07-15	Ambrx, Inc.	Human growth hormone modified at position 35
RU2473696C1 (ru) *	2011-07-14	2013-01-27	Закрытое акционерное общество "ГЕНЕРИУМ"	ПРОМЫШЛЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА β-1b ЧЕЛОВЕКА ИЗ ТЕЛЕЦ ВКЛЮЧЕНИЯ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3897309A (en) *	1974-02-15	1975-07-29	Merck & Co Inc	Process for removing pyrogenic material from aqueous solutions
NL7605805A (nl) *	1976-05-28	1977-11-30	Stichting Rega V Z W	Werkwijze voor het zuiveren van interferon.
NL7907791A (nl) *	1979-10-23	1981-04-27	Stichting Rega V Z W	Werkwijze voor het zuiveren van interferon.
US4485038A (en) *	1982-10-19	1984-11-27	Health Research (Roswell Park Division)	Method for the production and purification of human leukocyte interferon
US4485017A (en) *	1982-12-22	1984-11-27	Cetus Corporation	Isolation of human interferon by immunosorbent and high performance liquid chromatography
IL67896A (en) *	1983-02-13	1987-03-31	Yeda Res & Dev	Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them
US4894330A (en) *	1986-12-23	1990-01-16	Cetus Corporation	Purification of recombinant beta-interferon incorporating RP-HPLC

1987
- 1987-07-31 IT IT21560/87A patent/IT1222427B/it active
1988
- 1988-07-13 ES ES88111201T patent/ES2046999T3/es not_active Expired - Lifetime
- 1988-07-13 EP EP88111201A patent/EP0301314B1/de not_active Expired - Lifetime
- 1988-07-13 AT AT88111201T patent/ATE98257T1/de not_active IP Right Cessation
- 1988-07-13 DE DE88111201T patent/DE3886118T2/de not_active Expired - Fee Related
- 1988-07-18 US US07/220,312 patent/US5066786A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IT1222427B (it)	1990-09-05
IT8721560A0 (it)	1987-07-31
US5066786A (en)	1991-11-19
EP0301314A3 (en)	1990-05-30
EP0301314A2 (de)	1989-02-01
DE3886118D1 (de)	1994-01-20
EP0301314B1 (de)	1993-12-08
ES2046999T3 (es)	1994-02-16
DE3886118T2 (de)	1994-04-07

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Legal Events

Date	Code	Title	Description
1994-08-15	UEP	Publication of translation of european patent specification
1996-04-15	REN	Ceased due to non-payment of the annual fee